Da Fang¹, Xianbing Chen^2,*, Chenxiao Chu^3,*, Xinhou Liu⁴, Mengyu Zhu⁵, Jinliang Zhu⁶

Frontiers in Heat and Mass Transfer, Vol.24, No.3, 2026, DOI:10.32604/fhmt.2026.079777 - 29 June 2026

Abstract A three-dimensional numerical model of a water-driven steam ejector was developed using the Euler-Euler two-fluid framework. A direct-contact condensation (DCC) heat and mass transfer model was employed to simulate the complex two-phase flow and energy exchange. The distributions of gas-liquid phases, pressure, and temperature were obtained to evaluate performance. Results indicate that within the investigated operating range (p_p = 140–160 kPa), the entrainment ratio (ER) and temperature rise (DT) are highly coupled, with DT varying from 5.33 to 11.49 K. The maximum temperature rise of 11.49 K was achieved at p_p = 140 kPa, T_p = 310 K,… More >

Si-Han Chen^1,#, Yun Song^2,#,*, Xian-Yin Li³, Jun-Ping Zhou², I-Hua Chen^3,*

International Journal of Mental Health Promotion, Vol.28, No.6, 2026, DOI:10.32604/ijmhp.2026.079774 - 23 June 2026

Abstract Backgrounds: In the digital era, smartphone-driven phubbing behavior has become increasingly prevalent among teachers and may contribute to insomnia. Psychological distress has been identified as a potential mechanism linking maladaptive technology use to sleep problems; however, this mediating pathway has not been examined longitudinally. Furthermore, gender differences in these associations remain unclear. This study aimed to examine the longitudinal relationship between phubbing behavior and insomnia, the mediating role of psychological distress, and the moderating role of gender. Methods: A two-wave longitudinal design with a four-month interval was employed. At Time 1 (T1), 1061 teachers participated, with… More >

Zhengzheng Li^1,2,#, Haitong Xie^1,2,#, Yujuan Chen^1,2, Qiuyan Li³, Xing Yuan⁴, Xinyue Dai³, Jie Chen^1,2,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081209 - 16 June 2026

Abstract Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. Phosphoglycerate kinase 1 (PGK1) drives TNBC progression, but mechanisms governing its protein stability remain unclear. This study aims to identify the E3 ubiquitin ligase responsible for PGK1 degradation and evaluate its therapeutic potential against metastasis. Methods: Clinical datasets and 50 human TNBC tissues were analyzed via multiplex immunohistochemistry. Co-immunoprecipitation, ubiquitination linkage assays, and structural modeling were utilized for in vitro mechanistic studies in TNBC cells. Additionally, functional impacts on epithelial-mesenchymal transition (EMT) and metastasis were evaluated using transwell assays and an in vivo mouse lung metastasis… More >

Xingchen Zhu¹, Haohan Zhao^2,*, Wencan Li^3,*, Zixu Wang¹

International Journal of Mental Health Promotion, Vol.28, No.5, 2026, DOI:10.32604/ijmhp.2026.078033 - 28 May 2026

Abstract Backgrounds: Adolescent psychological well-being has become a pressing global concern, with rising levels of emotional distress among youth. Although prior research highlights the positive influence of teacher–student relationships, the underlying mechanisms—particularly the roles of school belonging, moral disengagement, and growth mindset—remain insufficiently understood. This study investigates the associations between teacher-student relationship quality and adolescent psychological well-being, examining school belonging and moral disengagement as potential mediators, and growth mindset as a moderator of these relationships. Methods: A total of 785 adolescents were recruited from six schools across Shanghai and Liaoning Province, China. Participants completed validated measures of… More >

Abdul Aabid^1,*, Renita Sharon Monis², Ambareen Khan³, Sher Afghan Khan⁴, Muneer Baig¹

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.076988 - 27 May 2026

Abstract Separated flow at a blunt base remains a critical topic in both automotive and aerospace engineering, particularly in the context of high-speed and supersonic vehicles such as modern fighter aircraft. In the separated region, characterized by a recirculation zone, the local pressure is typically lower than the ambient back pressure. This reduced base pressure can account for up to 70 percent of the total drag acting on an axisymmetric body. The present study focuses on regulating the base pressure within the recirculation region to reduce base drag and thereby enhance the operational range of rockets,… More >

Roshana Mukhtar¹, Chuan-Yu Chang², Muhammad Asif Zahoor Raja^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.079390 - 27 May 2026

Abstract Parkinson’s disease (PD) is a complex neurodegenerative disease associated with the accumulation of α-synuclein, which is linked to the dysfunctional ubiquitin–proteasome system. Fractional calculus has emerged as a powerful tool for modeling complex disease dynamics due to its promising features that inherently capture memory and hereditary effects. This paper presents a fractional-order Proteasome-Fibril interaction model (F-PFIM) for the dynamics of PD, represented by three fractional differential classes, showing concentrations of fibrils (F), proteasomes (P), and proteasome fibril complex (C). The three classes of the F-PFIM collectively make a controlling system that works for the clearance… More > Graphic Abstract

Haitian Du^*

Journal of Cyber Security, Vol.8, pp. 241-279, 2026, DOI:10.32604/jcs.2026.075976 - 25 May 2026

Abstract Modern cyberattacks evolve rapidly, overwhelming static and rule-based defenses. This paper proposes GenAI-Powered Autonomous Cyber Offense-Defense, a closed-loop framework in which large language models (LLMs) control both a red-team attacker and a blue-team defender. The agents operate in a simulated enterprise network, generate natural-language rationales for every action, and update defensive policies through a self-adaptive learning loop. We instantiate the framework with LLM-based agents that plan multi-stage attacks, detect anomalies, and autonomously execute containment and hardening actions. In experiments on a three-host virtualized testbed and a scalable multi-node emulation, the adaptive blue agent reduces the More >

Yi-Sian Huang^1,2, Chung-Yung Ma^1,2, Hsiao-Yuh Roan³, Cheng-Hsiung Chiang⁴, Hsiao-Hui Tsou⁴, Chen-Hui Chen³, Yi-Fan Lin², Horng-Dar Wang², Chiou-Hwa Yuh^1,5,6,7,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.074145 - 21 May 2026

Abstract Objectives: Hepatocellular carcinoma (HCC) arising in metabolic dysfunction–associated steatotic liver disease (MASLD) develops under lipid-rich stress and inflammatory remodeling, which can alter therapeutic windows. We aimed to determine whether phenotypic response surface–guided optimization (PRS-OPT) can nominate hepatocyte-sparing propolis–metformin–regorafenib (PMR) dose windows that retain antitumor activity under MASLD-like fatty-acid (FA) stress and translate to an in vivo immune endpoint. Methods: PMR combinations were profiled in hepatoma cell lines (PLC/PRF/5 and HepG2) and non-malignant hepatocytes (THLE-2) under FA-free and FA-enriched conditions. Quadratic response surfaces were fitted and used for constrained dose nomination, followed by in vitro validation. Cell-death contributions were… More >

Ralf Weiskirchen¹, Amedeo Lonardo^2,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076177 - 13 May 2026

Abstract Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver health differently. One significant cause of chronic liver diseases among those living with obesity is metabolic dysfunction-associated steatotic liver disease (MASLD), which is linked to one or more cardiometabolic risk factors in individuals who do not engage in harmful alcohol consumption. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is increasingly being associated with MASLD through intricate immunological, cellular, proinflammatory, molecular, and genetic mechanisms. In this review, we More > Graphic Abstract

Gaeul Kim¹, Dohoon Kim^2,*

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.078931 - 08 May 2026

Abstract Manned-Unmanned Teaming (MUM-T) is an operational system where manned and unmanned systems perform missions through a collaboration interface, expanding beyond defense into civilian domains. The core of MUM-T lies in the organic interaction between manned and unmanned systems. The Collaboration Interface enabling this interaction becomes a primary target for cyber attacks due to its reliance on wireless networks. Compromising the reliability of the collaboration interface goes beyond simple communication failures; it directly leads to mission failure and aircraft safety issues. Therefore, systematic threat analysis and assessment tailored to this specific domain are essential. This study… More >