VIGNESH BALAJI E¹, DIVYA RAMESH², MANISHA CHUNGAN SHAJU³, AKSHARA KUMAR⁴, SAMYAK PANDEY¹, RAKSHA NAYAK¹, V. ALKA⁵, SRISHTI MUNJAL⁶, AMIR SALIMI⁷, K. SREEDHARA RANGANATH PAI^1,*, SHANKAR M. BAKKANNAVAR²

Oncology Research, Vol.32, No.1, pp. 73-94, 2024, DOI:10.32604/or.2023.030401

Abstract Exosomes, small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human body. It is considered a “double-edged sword”, and depending on its biological source, the action of exosomes varies under physiological conditions. Also, the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome source. Moreover, the uptake of exosomes from the recipients’ cells is a vital and initial step for all the physiological actions. There are different mechanisms present in the exosomes’ cellular… More > Graphic Abstract

QIUQIANG CHEN^1,*, XIAOLEI ZHAO², WENXUE MA^3,*

Oncology Research, Vol.32, No.1, pp. 95-98, 2024, DOI:10.32604/or.2023.046174

Abstract Greenblatt and his team have unveiled vertebral skeletal stem cells (vSSCs) as a critical player in the landscape of bone metastasis. This commentary delves into the transformative discoveries surrounding vSSCs, emphasizing their distinct role in bone metastasis compared to other stem cell lineages. We illuminate the unique properties and functions of vSSCs, which may account for the elevated susceptibility of vertebral bones to metastatic invasion. Furthermore, we explore the exciting therapeutic horizons opened by this newfound understanding. These include potential interventions targeting vSSCs, modulation of associated signaling pathways, and broader implications for the treatment and management of bone metastasis. By… More > Graphic Abstract

ABHISHEK WAHI¹, MAMTA BISHNOI², NEHA RAINA¹, MEGHNA AMRITA SINGH¹, PIYUSH VERMA¹, PIYUSH KUMAR GUPTA^3,4, GINPREET KAUR⁵, HARDEEP SINGH TULI^6,*, MADHU GUPTA^1,*

Oncology Research, Vol.32, No.1, pp. 19-47, 2024, DOI:10.32604/or.2023.042228

Abstract Cancer is a leading cause of death globally, with limited treatment options and several limitations. Chemotherapeutic agents often result in toxicity which long-term conventional treatment. Phytochemicals are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the resistance. These phytoconstituents act in several ways and deliver optimum effectiveness against cancer. Nevertheless, the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility, bioavailability, and stability. Nanotechnology presents a promising avenue for transforming current cancer treatment methods through the… More > Graphic Abstract

VIBHAV VARSHNEY^1,*, PRASHANT SINGH KUSHWAH², NEETU AGRAWAL¹, AHSAS GOYAL^1,*, GOVIND SINGH²

BIOCELL, Vol.47, No.10, pp. 2141-2149, 2023, DOI:10.32604/biocell.2023.030853

Abstract The persistent global pandemic, COVID-19, stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yielding an unprecedented worldwide crisis. With reference to a WHO report, the count of COVID-19 cases had exceeded 754 million by February 03, 2023. Intriguingly, emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities, acting as potent immunomodulatory factors at the cellular and molecular levels. This interconnection operates through a series of dynamic mechanisms. SARS-CoV-2 infection perturbs the delicate equilibrium of gut microbiota, leading to dysbiosis—a signature biomarker. This imbalance is intrinsically linked to exacerbated COVID-19 progression. Mechanistically,… More >

PAVITHRA SUBRAMANI^1,2, RAUNAK KUMAR DAS^1,*

BIOCELL, Vol.47, No.10, pp. 2195-2205, 2023, DOI:10.32604/biocell.2023.030383

Abstract Solar ultraviolet B (UVB) radiation is a major skin cancer-causing agent. Initiation, promotion, and progression are the diverse phases of UVB-induced carcinogenesis. Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways: thymine dimer formation, DNA damage, oxidative stress, inflammatory responses, and altered cell signaling, eventually resulting in tumor formation. The increased skin cancer rates urge researchers to develop more efficient drugs, but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues, which have been reported recently. The current review focuses on the relationship between microbes and cancer. Human skin acts as a barrier against… More > Graphic Abstract

SHENGJIE SONG, ZHIZHOU SHI^*

BIOCELL, Vol.47, No.10, pp. 2207-2215, 2023, DOI:10.32604/biocell.2023.027677

Abstract Metabolic reprogramming frequently occurs in the majority of cancers, wherein fatty acid oxidation (FAO) is usually induced and serves as a compensatory mechanism to improve energy consumption. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO and is widely involved in tumor growth, metastasis, and chemo-/radio-resistance. This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis, including in proliferation and tumor growth, invasion and metastasis, and the tumor microenvironment. Importantly, CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,… More > Graphic Abstract

CHUNYANG XU^1,#, CAIYUN YANG^1,#, JINSONG ZHANG², XIAOHUA PAN³, JUN WANG⁴, LEI JIANG², HONGWEI YE^1,*, BO CHEN^1,*

BIOCELL, Vol.47, No.9, pp. 2027-2035, 2023, DOI:10.32604/biocell.2023.029277

Abstract Background: The lung is one of the primary target organs of hydrogen sulfide (H₂S), as exposure to H₂S can cause acute lung injury (ALI) and pulmonary edema. Dexamethasone (Dex) exerts a protective effect on ALI caused by exposure to toxic gases and is commonly used in the clinic; however, the underlying mechanisms remain elusive, and the dose is unclear. Methods: In vivo experiments: divided C57BL6 mice into 6 groups at random, 12 in each group. The mice were exposed to H₂S for 3 h and 5 or 50 mg/kg Dex pretreated before exposure, sacrificed 12 h later. The morphological changes… More >

LU SUN^1,2, HUAICHENG TAN¹, TING YU³, RUICHAO LIANG^4,*

Oncology Research, Vol.31, No.6, pp. 967-988, 2023, DOI:10.32604/or.2023.042309

Abstract Lung adenocarcinoma (LUAD) is the most common and deadliest subtype of lung cancer. To select more targeted and effective treatments for individuals, further advances in classifying LUAD are urgently needed. The number, type, and function of T cells in the tumor microenvironment (TME) determine the progression and treatment response of LUAD. Long noncoding RNAs (lncRNAs), may regulate T cell differentiation, development, and activation. Thus, our aim was to identify T cell-related lncRNAs (T cell-Lncs) in LUAD and to investigate whether T cell-Lncs could serve as potential stratifiers and therapeutic targets. Seven T cell-Lncs were identified to further establish the T… More >

FENGMEI QIAN^1,2, PEIYAO REN², LI ZHAO², DANNA ZHENG², WENFANG HE³, JUAN JIN^3,*

BIOCELL, Vol.47, No.8, pp. 1853-1867, 2023, DOI:10.32604/biocell.2023.029353

Abstract Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms of the compound celastrol derived from the medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained from Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related targets were retrieved from GeneCards, DisGeNET, and Therapeutic Targets Database (TTD). A Protein-protein interaction (PPI) network was established using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using ClusterProfiler. The cytoHubba plugin was used to select… More > Graphic Abstract

H. Zarglayoun, C. Arbour, J. Delage, S. Pierre, M. Tremblay, D. Hjeij, P. Rainville, D. Ogez

Psycho-Oncologie, Vol.16, No.4, pp. 375-379, 2022, DOI:10.3166/pson-2022-0202

Abstract Objective: This project aimed to train nurses on an oncology unit in hypnotic communication to reduce treatment-related pain and anxiety in their patients. A pilot study was conducted to assess changes in hypnotic communication behaviors associated with the training.
Methods: Nurses were recruited and their interactions during a simulated patient admission for treatment (before and after training) were recorded. Hypnotic communication skills were assessed by independent reviewers using a training checklist listing different hypnotic communication techniques and a validated assessment scale (Sainte-Justine Hypnotic Communication Assessment Scale, SJ-HCAS).
Results: Seven nurses were evaluated. Wilcoxon pairedsample tests (pre–post) reported significant improvement with… More >