Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Priyadarshini Patel, Komal Parmar^*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2855-2903, 2025, DOI:10.32604/fdmp.2025.069428 - 31 December 2025

Abstract Tissue engineering has advanced remarkably in developing functional tissue substitutes for pharmaceutical and regenerative applications. Among emerging technologies, three-dimensional (3D) printing, or additive manufacturing, enables precise fabrication of biocompatible materials, living cells, and scaffolds into complex, viable constructs. Within regenerative medicine, 3D bioprinting addresses the growing demand for transplantable tissues and organs by assembling biological materials that replicate native architectures. This paper reviews biomaterials used in 3D bioprinting, emphasizing how their rheological behavior, particularly viscoelasticity and thixotropy, governs printability, structural fidelity, and cellular viability. The advantages and limitations of natural, synthetic, and composite bioinks are More > Graphic Abstract

Wenxiang Zhang^1,2, Wenning Cui¹, Juan Huang³, Zhangen Lu¹, Kuijing Liang¹, Lingbao Wang^1,2, Shanshan Wei^1,2, Liran Shi¹, Huifen Li¹, Xiaoli Guo^1,2,*, Jianhui Ma^4,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3893-3912, 2025, DOI:10.32604/phyton.2025.073736 - 29 December 2025

Abstract UDP-glycosyltransferases (UGTs) play essential roles in plant secondary metabolism and stress responses, yet their composition and functions in Sorghum bicolor, a model C4 plant, remain inadequately characterized. This study identified 196 SbUGT genes distributed across all 10 chromosomes and classified them into 16 subfamilies (A–P) through phylogenetic analysis. Among these, 61.2% were intronless, and 10 conserved motifs, including the UGT-specific PSPG box, were identified. Synteny analysis using MCScanX revealed 12 segmental duplication events and conserved syntenic relationships with other Poaceae species (rice, maize, and barley). Promoter analysis uncovered 125 distinct cis-acting elements, predominantly associated with stress and… More >

Lijuan Zhang¹, Yu Zhou², Jiawei Tian^3,*, Fupei Guo⁴, Xiang Zhang⁴, Bo Yang^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3949-3968, 2025, DOI:10.32604/cmes.2025.071869 - 23 December 2025

Abstract In endoscopic surgery, the limited field of view and the nonlinear deformation of organs caused by patient movement and respiration significantly complicate the modeling and accurate tracking of soft tissue surfaces from endoscopic image sequences. To address these challenges, we propose a novel Hybrid Triangular Matching (HTM) modeling framework for soft tissue feature tracking. Specifically, HTM constructs a geometric model of the detected blobs on the soft tissue surface by applying the Watershed algorithm for blob detection and integrating the Delaunay triangulation with a newly designed triangle search segmentation algorithm. By leveraging barycentric coordinate theory, More >

Federico Greco^1,2,*, Marco Cataldo³, Valerio D’Andrea^2,4, Luca Pugliese⁵, Andrea Panunzio⁶, Alessandro Tafuri⁶, Bruno Beomonte Zobel^2,4, Carlo Augusto Mallio^2,4

Canadian Journal of Urology, Vol.32, No.5, pp. 433-443, 2025, DOI:10.32604/cju.2025.068390 - 30 October 2025

Abstract Background: Radiogenomics offers a non-invasive approach to correlate imaging features with tumor molecular profiles. This study aims to identify computed tomography (CT) imaging characteristics associated with positive NIPA-like domain containing 4 (NIPAL4) expression in clear cell renal cell carcinoma (ccRCC) and to develop a radiogenomic predictive model to support personalized risk stratification. Methods: A retrospective analysis was conducted on 241 ccRCC patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) databases. Clinical, pathological, and CT features were compared between NIPAL4-positive and NIPAL4-negative groups. A penalized logistic regression model was built to… More >

Xiaolong Zhu, Feng Chen, Yuntian Chen, Wei Zhu, Xiaoxiao Han^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.012584

Abstract Human tissues and organs exhibit not only intricate anatomical architectures but also spatially heterogeneous distributions of elastic modulus—for example, between cancellous and cortical bone, across the epidermis, dermis, and subcutaneous layers, and between healthy and fibrotic liver tissues. Conventional biomaterials often fail to replicate such mechanical heterogeneity, thereby limiting their capacity to recreate biomimetic physiological microenvironments essential for applications like tissue regeneration and disease modeling. Meta-biomaterials, artificially engineered through the rational structural design of continuous materials, have emerged as a promising class of materials owing to their highly tunable mechanical and biological properties. These attributes… More >

Chao Gui^1,2, Wanying Chang³, Yaping Liu^1,*, Leren Tao³, Daoming Shen¹, Mengyi Ge¹

Frontiers in Heat and Mass Transfer, Vol.23, No.5, pp. 1621-1637, 2025, DOI:10.32604/fhmt.2025.072268 - 31 October 2025

Abstract Freeze-drying of structurally heterogeneous biomaterials such as porcine aorta presents considerable modeling challenges due to their inherent multilayer composition and moving sublimation interfaces. Conventional models often overlook structural anisotropy and dynamic boundary progression, while experimental determination of key parameters under cryogenic conditions remains difficult. To address these, this study develops a heat and mass transfer model incorporating a dynamic node strategy for the sublimation interface, which effectively handles continuous computational domain deformation. Additionally, specialized fixed nodes were incorporated to adapt to the multilayer structure and its spatially varying thermophysical properties. A novel non-contact gravimetric system More > Graphic Abstract

Matthew Rubinstein^1,*, Madeline Lauren Hong¹, Rishi Kumar Nanda¹, Daniel Thomas Jones¹, Hazem Aboaid², Yin Mon Myat³, Kyaw Zin Thein⁴

Oncology Research, Vol.33, No.11, pp. 3161-3183, 2025, DOI:10.32604/or.2025.067791 - 22 October 2025

Abstract The ever-expanding development of tissue-agnostic therapies which target malignancies based on specific mutations rather than tissue origin have transformed the landscape of oncology. The purpose of this review is to explore the impact, safety, and challenges of tissue-agnostic therapies including pembrolizumab, dostarlimab, larotrectinib, entrectinib, repotrectinib, dabrafenib plus trametinib, selpercatinib, and trastuzumab deruxtecan. As the therapeutic arsenal continues to grow, it is crucial to understand how these therapies truly benefit patients and to address the barriers that stand in the way of making them more widely available. Although these therapies have shown effectiveness across multiple cancer More >

Md. Tanvir Raihan¹, Md. Himel Mahmud², Badhon Chandra Mazumder², Md. Nazif Hasan Chowdhury³, Mohammad Tajul Islam^1,*

Journal of Polymer Materials, Vol.42, No.3, pp. 677-711, 2025, DOI:10.32604/jpm.2025.068356 - 30 September 2025

Abstract Electrospinning has gained significant importance across various fields, including biomedicine, filtration, and packaging due to the control it provides over the properties of the resulting materials, such as fiber diameter and membrane thickness. Chitosan is a biopolymer that can be utilized with both natural and synthetic copolymers, owing to its therapeutic potential, biocompatibility, and biodegradability. However, producing electrospun chitosan is challenging due to its high solution viscosity, which often results in the formation of beads instead of uniform fibers. To address this issue, the spinnability of chitosan is significantly enhanced, and the production of continuous More >

Imandeena Sofileeya^1,2, Surajudeen Sikiru^1,2,*, Nur Hidayah Shahemi¹, Niraj Kumar³, Mohd Muzamir Mahat^1,*

Journal of Polymer Materials, Vol.42, No.3, pp. 713-728, 2025, DOI:10.32604/jpm.2025.065378 - 30 September 2025

Abstract Spinal cord injury presents a significant challenge in regenerative medicine due to the complex and delicate nature of neural tissue repair. This study aims to design a conductive hydrogel embedded with magnetic MgFe₂O₄ nanoparticles to establish a bioelectrically active and spatially stable microenvironment that promotes spinal cord regeneration through computational analysis (BIOVIA Materials Studio). Hydrogels, known for their biocompatibility and extracellular matrix-mimicking properties, support essential cellular behaviors such as adhesion, proliferation, and migration. The integration of MgFe₂O₄ nanoparticles imparts both electrical conductivity and magnetic responsiveness, enabling controlled transmission of electrical signals that are crucial for guiding… More >