Osama M. Alshehri1, Ahmad Shaf2,*, Muhammad Irfan3,*, Mohammed M. Jalal4, Malik A. Altayar4, Mohammed H. Abu-Alghayth5, Humood Al Shmrany6, Tariq Ali7, Toufique A. Soomro8, Ali G. Alkhathami9
CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 1165-1196, 2025, DOI:10.32604/cmes.2025.067150
- 31 July 2025
Abstract Background: Accurate classification of normal blood cells is a critical foundation for automated hematological analysis, including the detection of pathological conditions like leukemia. While convolutional neural networks (CNNs) excel in local feature extraction, their ability to capture global contextual relationships in complex cellular morphologies is limited. This study introduces a hybrid CNN-Transformer framework to enhance normal blood cell classification, laying the groundwork for future leukemia diagnostics. Methods: The proposed architecture integrates pre-trained CNNs (ResNet50, EfficientNetB3, InceptionV3, CustomCNN) with Vision Transformer (ViT) layers to combine local and global feature modeling. Four hybrid models were evaluated on… More >