Ravi Samikannu^{1, *}, Rohini Ravi², Sivaram Murugan³, Bakary Diarra⁴

CMC-Computers, Materials & Continua, Vol.63, No.3, pp. 1133-1142, 2020, DOI:10.32604/cmc.2020.08578

Abstract The identification of brain tumors is multifarious work for the separation of the similar intensity pixels from their surrounding neighbours. The detection of tumors is performed with the help of automatic computing technique as presented in the proposed work. The non-active cells in brain region are known to be benign and they will never cause the death of the patient. These non-active cells follow a uniform pattern in brain and have lower density than the surrounding pixels. The Magnetic Resonance (MR) image contrast is improved by the cost map construction technique. The deep learning algorithm for differentiating the normal brain… More >

Tiangen WU¹, Tianhao BAO^2,3, Daoming LIANG^1,*, Lin WANG^4,*

BIOCELL, Vol.43, No.4, pp. 293-298, 2019, DOI:10.32604/biocell.2019.07841

Abstract Circulating tumor cells (CTCs) are crucial to tumor metastasis, and they usually undergo epithelial– mesenchymal transition (EMT) in order to disseminate from the primary tumor. However, very little is currently known about the relationship between EMT and malignant phenotypes of CTCs in the context of gastric cancer. Therefore, this study aimed to investigate the contribution of EMT to malignant phenotypes of CTCs derived from gastric cancer cells. We xenografted MKN28 gastric cancer cells pretreated with transforming growth factor-beta 1 (TGFβ-1) into nude mice by intravenous injection. Next, we isolated CTCs from the blood of nude mice by gradient centrifugation and… More >

SAMIN HONG, KYOUNGSOO PARK, CHAN YUN KIM, GONG JE SEONG

BIOCELL, Vol.32, No.2, pp. 201-205, 2008, DOI:10.32604/biocell.2008.32.201

Abstract The effect of hypoxia on the release of tumor necrosis factor-α (TNF-α) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-α in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100 μM agmatine. The expression levels of TNF-α and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-α production in RGCs. Agmatine significantly reduced TNF-α level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or… More >

M. Sánchez Negrette, M.A. Montenegro, M.S. Catuogno, W.J. Lértora, M.C. Guanziroli

BIOCELL, Vol.31, No.3, pp. 391-396, 2007, DOI:10.32604/biocell.2007.31.391

Abstract Epidemiological studies in human beings and experimental studies in laboratory animals suggest that milk and dairy products can inhibit effects on the development of some kinds of tumors. Cow milk contains sphingomyelin, butyric acid, conjugated linoleic acid, calcium, vitamin A, carotene and vitamin D. All of these components are known to inhibit the process of carcinogenesis. Our objective was to determine the effect of cow milk and water buffalo milk on the development of colon neoplasias in an experimental model of carcinogenesis in rats induced with 1,2-dimethylhydrazine (DMH). Three-month-old Wistar male rats with an average body weight of 180 g… More >

Hao Sun¹, Timothy Eswothy¹, Kerlin P. Robert¹, Jiaoyan Li², L. G. Zhang¹, James D. Lee^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 75-75, 2019, DOI:10.32604/mcb.2019.07090

Abstract Most biological phenomena commonly involve with mechanics. In this work, we proposed an innovative model that tumor is considered as a pyroelastic medium consisting of two parts: solid and fluid. The variation of solid part depends on whether the drug has been effectively delivered to the tumor site. We derived the governing equations of the tumor, in which large deformation is incorporated. Meanwhile, the finite element equations for coupled displacement field and pressure field are formulated. We proposed two sets of porosity and growth tensor. In both cases the continuum theory and FEM are accompanied by accurate numerical simulations. To… More >

Peng Jing¹, Xiaolong Wang¹, Shigeho Noda², Xiaobo Gong^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 36-37, 2019, DOI:10.32604/mcb.2019.07111

Abstract The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. The moving behavior and stress distribution of circulating tumor cells under different geometry and flow conditions are important basis for studying the adhesion between circulating tumor cells and vessel walls. In the present work, the motion and deformation of circulating tumor cells in capillary tubes are numerically studied using the immersed boundary method (IBM). The membrane stress distribution of CTCs in confined tubes are investigated with under vessel diameters, hematocrit (Ht) values and capillary numbers (Ca). The results show that the… More >

M.A. MONTENEGRO^*, M. SÁNCHEZ NEGRETTE^*, E.J. GIMENO^**, J.T. BORDA^*

BIOCELL, Vol.26, No.3, pp. 339-345, 2002, DOI:10.32604/biocell.2002.26.339

Abstract Wistar male rats, 3 months of age were given ad-libitum a nutritionally adequate diet and demineralized drinking water. The Molybdenum (Mo) and Tungsten (W) were provided in the drinking water at 200 ppm concentration. Intestinal tumors were induced by 1,2-dimethylhydrazine (DMH) given subcutaneously as 16 weekly doses at 20 mg/kg body weight. Mo in the form of (NH₄)₆ Mo₇O₂₄ 4H₂O or W in the form of (Na₂ WO₄) were provided in the drinking water two months before the first DMH treatment and were continued during 4 months more until the last DMH treatment. Three months after the last carcinogen injection,… More >

Hong TIAN^{1, 2}, Peiyu CONG³, Ruiqun QI⁴, Xinghua GAO⁵, Xin LIU⁶, Hongsheng LIU⁷, Fengping SHAN^1,*

BIOCELL, Vol.41, No.1, pp. 27-32, 2017, DOI:10.32604/biocell.2017.41.027

Abstract Glioma is one of the lethal central nervous system tumors. The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues, resulting in inevitable recurrence after surgery operation. Gliomas do not metastasize, so to prevent the residual tumor from proliferating or invading is a key challenge. Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’ activities. Using a hypotaurine synthesis deficient U251 cell line, we proved that the cells invasion ability was impaired. Gene expression profile analysis exhibited that knocking down one of the key enzymes of hypotaurine synthesis,… More >

Hoda M. EL-EMSHATY¹, Entsar A. SAAD², Mona S. GOUIDA³, Zahraa R. ELSHAHAWY^1,2

BIOCELL, Vol.42, No.2, pp. 55-60, 2018, DOI:10.32604/biocell.2018.07009

Abstract Hepatitis C virus (HCV)-cirrhotic patients have the highest threat of developing hepatocellular carcinoma (HCC) and may be at risk of extra hepatic cancer. The present study was designed to investigate CD133 and CK19 in HCV (genotype-4)-cirrhotic patients with/without HCC or extra hepatic cancer, to assess the degree of their correlation with cell cycle abnormalities and finally to assess the role of their combination as diagnostic tool for discrimination of cirrhotic patients with HCC from those with extra hepatic cancer. The study included 77 HCV-cirrhotic patients and 20 healthy non-disease control group. Patients were categorized histo-pathologically into: 24 have only liver… More >

Bingbing ZHANG^{1, 2}, Ying ZHANG^{1, 2}, Xiaomei ZHANG^{1, 2}, Yonggang LV^{1, 2}

BIOCELL, Vol.42, No.1, pp. 17-24, 2018, DOI:10.32604/biocell.2018.06115

Abstract Mechanical microenvironment can strongly affect the metastatic efficiency of circulating tumor cells. However, the effect of suspension state on their extravasation and the mechanisms involved are still unclear. To explore the influence of suspension state on extravasation (including adhesion, spreading and transendothelial migration) of breast tumor cells and its relevant molecular mechanism, MDA-MB-231 cells were cultured on poly (2-hydroxyethyl methacrylate) coated 6-well plates to minic the suspension state. Suspension state promoted adhesion, spreading and transendothelial migration of MDA-MB-231 cells to EAhy926 endothelial cells (ECs) monolayer under both the static condition and 0.5 dyne/cm² flow shear stress (FSS). The number of… More >