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  • Open Access

    ARTICLE

    Prognostic and Predictive Significance of Eukaryotic Elongation Factor 1D (eEF1D) in Breast Cancer: A Potential Marker of Response to Endocrine Therapy

    Burcu BİTERGE SÜT1,*, Ayşe İKİNCİ KELEŞ2

    Oncologie, Vol.22, No.3, pp. 147-154, 2020, DOI:10.32604/oncologie.2020.014449

    Abstract Components of the protein synthesis machinery are subjected to alterations in cancer cells. eEF1D gene, which lies within the frequently amplified 8q24 locus, is one of the subunits of the human eukaryotic elongation factor complex. This study aimed to evaluate the prognostic and predictive significance of eEF1D in breast cancer using in silico analysis tools. For this purpose, we analyzed genomic alterations of the eEF1D gene using TCGA datasets via cBioPortal. Histopathological analysis was performed on patient tissue images obtained from cBioPortal and the Human Protein Atlas. Survival analysis was carried out using the KM… More >

  • Open Access

    ARTICLE

    Two Stage Classification with CNN for Colorectal Cancer Detection

    Pallabi Sharma1,*, Kangkana Bora2, Kunio Kasugai3, Bunil Kumar Balabantaray1

    Oncologie, Vol.22, No.3, pp. 129-145, 2020, DOI:10.32604/oncologie.2020.013870

    Abstract In this paper, we address a current problem in medical image processing, the detection of colorectal cancer from colonoscopy videos. According to worldwide cancer statistics, colorectal cancer is one of the most common cancers. The process of screening and the removal of pre-cancerous cells from the large intestine is a crucial task to date. The traditional manual process is dependent on the expertise of the medical practitioner. In this paper, a two-stage classification is proposed to detect colorectal cancer. In the first stage, frames of colonoscopy video are extracted and are rated as significant if More >

  • Open Access

    ARTICLE

    Cancer du Sein: Délais d’Accès au Diagnostic et aux Traitements Etude Rétrospective–Batna, Algérie Août 2015–Février 2016

    Fadhila Mansour1,2,*, Abdelhak Lakehal2,3, Lahcène Nezzal2,3

    Oncologie, Vol.22, No.3, pp. 117-128, 2020, DOI:10.32604/oncologie.2020.014979

    Abstract L’objectif de cette étude était de quantifier les délais de prise en charge des femmes atteintes de cancer du sein prises en charge au niveau du centre anticancer de Batna, Algérie. Il s’agissait d’une étude rétrospective à visée descriptive effectuée durant la période Août 2015 à Février 2016. Afin de retracer l’historique du parcours depuis les premiers signes d’apparition du cancer jusqu’aux premiers traitements, un questionnaire a été renseigné à partir des dossiers médicaux et complété par une interview auprès des patientes. 267 patientes ont été incluses dans l’étude. Le délai médian de prise en More >

  • Open Access

    ARTICLE

    Comprehensive Network Analysis of Different Subtypes of Molecular Disorders in Lung Cancer

    Haoliang Zhang1,*, Xiaowei Xing2, Yang Liu1, Shuangli Li1, Weiyuan Li3

    Oncologie, Vol.22, No.2, pp. 107-116, 2020, DOI:10.32604/oncologie.2020.012494

    Abstract Lung cancer is the leading cause of death in cancer patients. Based on a modular and comprehensive analysis method, it is intended to identify their common pathogenesis. We downloaded data and analyzed differences in lung adenocarcinoma samples, lung squamous cell carcinoma samples, and normal samples. Co-expression analysis, enrichment analysis, and hypergeometric testing were used to predict transcription factors, ncRNAs, and retrospective target genes. We get 4596 differentially expressed genes in common differences in high multiples and clustered into 14 modules dysfunction. The 14 genes (including DOK2, COL5A1, and TSPAN8) have the highest connectivity in the… More >

  • Open Access

    ARTICLE

    Clinical Significance of CA-199 and LINC01197 in Pancreatic Cancer

    Dan Zhang1, Shengyong Fu2,*, Jie Xu3, Xia Sun1

    Oncologie, Vol.22, No.2, pp. 95-105, 2020, DOI:10.32604/oncologie.2020.012439

    Abstract This study aimed to explore the expression and clinical significance of LINC01197 in the serum of patients with pancreatic cancer (PC). Methods: A total of 50 PC patients (patient group) treated in our hospital from March 2012 to April 2014 were collected, and another 50 healthy people (normal group) were collected for physical examination. The expression of LINC01197 in the serum of the two groups was detected by qRT-PCR method, and the expression of CA-199 in serum was detected by Roche automatic biochemistry. The expression and diagnostic values of CA-199 and LINC01197 in PC were analyzed,… More >

  • Open Access

    ARTICLE

    Expression and Clinical Significance of miR-152 and CYFRA21-1 in Ovarian Cancer Tissues

    Guiping Chen*, Tiantian Xie, Haibo Chen, Lijuan Chen

    Oncologie, Vol.22, No.2, pp. 83-93, 2020, DOI:10.32604/oncologie.2020.012491

    Abstract To investigate the expression and clinical significance of miR-152 and CYFRA21-1 in ovarian cancer (OC) tissues. Seventy-four OC patients diagnosed in our hospital from March 2016 to April 2019 (research group, RG) and 30 patients with benign ovarian tumor at the same time (control group, CG) were collected as research objects in this experiment. qRT-PCR and ELISA were used to detect and observe the expression levels of miR-152 in patient tissues and CYFRA21-1 in serum. ROC curves were drawn to analyze the diagnostic value of miR-152 and CYFRA21-1 in OC. The clinicopathological correlation analysis was… More >

  • Open Access

    ARTICLE

    Diagnosis of Lung Cancer Based on Plasma Metabolomics Combined with Serum Markers

    Dong Zhang1,#, Lingxia Tong2,#, Qingjun Wang1, Yunfeng Cao3, Yu Gao1, Donghua Yang1, Tianhao Bao4,5, Zhitu Zhu1,*

    Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376

    Abstract Predicting the onset and metastasis of early tumor is the primary means of improving lung cancer prognosis. The purpose of this study was to identify the ability of plasma metabolomics combined with blood markers to establish benign lung disease versus lung cancer regression models. Blood samples were collected from 174 lung cancer patients, 350 benign lung disease patients and 100 healthy volunteers and the metabolites were analyzed by mass spectrometry. The target metabolites consisted of 23 amino acids, 26 acylcarnitines and 45 conventional blood markers. A regression analysis model was established based on 12 metabolites… More >

  • Open Access

    ARTICLE

    The Relationship BRCA1/2 Genes and Family History in Ovarian Cancers

    Neslihan Duzkale1,*, Hikmet Taner Teker2

    Oncologie, Vol.22, No.2, pp. 65-74, 2020, DOI:10.32604/oncologie.2020.013707

    Abstract BRCA1/2 genes are responsible for the hereditary breast and ovarian cancer syndrome. In this study, Turkish women with ovarian cancer were investigated in terms of demographic, clinicopathologic and family cancer stories according to their condition of the BRCA1/2 genes mutation carrier. During 2011 to 2017 in Turkey, BRCA1 and BRCA2 genes were analyzed in 38 women, who were diagnosed with cancer using Next Generation Sequencing technique. Pathogenic mutations were detected in 9 (23.7%) of patients. The diagnosis age for Ovarian cancer patients for BRCA1/2 mutation carriers was found higher. It was seen that mutations mostly occurred in the… More >

  • Open Access

    REVIEW

    A Narrative Review: Classification of Pap Smear Cell Image for Cervical Cancer Diagnosis

    Wan Azani Mustafa1,*, Afiqah Halim1, Khairul Shakir Ab Rahman2

    Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660

    Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study… More >

  • Open Access

    ARTICLE

    Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors

    Chuanwei Xu1, Renju Ding2, Chuanping Xu3,*

    Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445

    Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were… More >

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