JIE ZHAO^1,#, XUANTAO YANG^2,#, HAIXI ZHANG¹, XUEZHONG GU^1,*

Oncology Research, Vol., , DOI: 10.32604/or.2023.030770

Abstract Multiple myeloma (MM) is a hematological tumor with high mortality and recurrence rate. Carfilzomib is a new-generation proteasome inhibitor that is used as the first-line therapy for MM. However, the development of drug resistance is a pervasive obstacle to treating MM. Therefore, elucidating the drug resistance mechanisms is conducive to the formulation of novel therapeutic therapies. To elucidate the mechanisms of carfilzomib resistance, we retrieved the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells and parental MM cells. Differential gene expression analyses revealed major alterations in the major histocompatibility complex (MHC) and cell adhesion molecules. The upregulation of the tumor… More >

Parakapali Roja¹, Shaik Mohammed Ibrahim², Thummala Sankar Reddy³, Giulio Lorenzini^4,*

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.042283

Abstract This study examines the behavior of a micropolar nanofluid flowing over a sheet in the presence of a transverse magnetic field and thermal effects. In addition, chemical (first-order homogeneous) reactions are taken into account. A similarity transformation is used to reduce the system of governing coupled non-linear partial differential equations (PDEs), which account for the transport of mass, momentum, angular momentum, energy and species, to a set of non-linear ordinary differential equations (ODEs). The Runge-Kutta method along with shooting method is used to solve them. The impact of several parameters is evaluated. It is shown that the micro-rotational velocity of… More >

Jiangshuai Wang^1,*, Chuchu Cai¹, Pan Fu^2,3, Jun Li^4,5, Hongwei Yang⁴, Song Deng¹

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.030430

Abstract Multi-gradient drilling is a new offshore drilling method. The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise control of the wellbore pressure. In this study, a new heat transfer model is proposed by which the variable mass flow is properly taken into account. Using this model, the effects of the main factors influencing the wellbore temperature are analyzed. The results indicate that at the position where the separation injection device is installed, the temperature increase of the fluid in the drill pipe is mitigated due… More >

G. Dharmaiah¹, F. Mebarek-Oudina^2,*, K. S. Balamurugan³, N. Vedavathi⁴

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.030325

Abstract The effects of a magnetic dipole on a nonlinear thermally radiative ferromagnetic liquid flowing over a stretched surface in the presence of Brownian motion and thermophoresis are investigated. By means of a similarity transformation, ordinary differential equations are derived and solved afterwards using a numerical (the BVP4C) method. The impact of various parameters, namely the velocity, temperature, concentration, is presented graphically. It is shown that the nanoparticles properties, in conjunction with the magnetic dipole effect, can increase the thermal conductivity of the engineered nanofluid and, consequently, the heat transfer. Comparison with earlier studies indicates high accuracy and effectiveness of the… More >

Matthew R. Coburn¹, Charlie Young², Chris Smith², Graham Schultz², Miguel Robayo³, Zheng-Tong Xie^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.028601

Abstract A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation, satisfying the ISO8 standard has been designed and analyzed in terms of performances. Unsteady Reynolds Averaged Navier-Stokes (URANS) models have been used to study the related flow field and particulate matter (PM) dispersion. The outcomes of the URANS models have been validated through comparison with equivalent large-eddy simulations. Special attention has been paid to the location and shape of the air intakes and their orientation in space, in order to balance the PM convection and diffusion inside the cleanroom. Forming a cyclone-type flow pattern inside the… More >

Fengting Luo, Ruwei Huang^*, Yuyue Chen

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2023.041676

Abstract Smart parks serve as integral components of smart cities, where they play a pivotal role in the process of urban modernization. The demand for cross-domain cooperation among smart devices from various parks has witnessed a significant increase. To ensure secure communication, device identities must undergo authentication. The existing cross-domain authentication schemes face issues such as complex authentication paths and high certificate management costs for devices, making it impractical for resource-constrained devices. This paper proposes a blockchain-based lightweight and efficient cross-domain authentication protocol for smart parks, which simplifies the authentication interaction and requires every device to maintain only one certificate. To… More >

Wei Li^1,2, Benjian Zou¹, Yuxiang Luo², Ning Yang², Faye Zhang^1,*, Mingshun Jiang¹, Lei Jia¹

Structural Durability & Health Monitoring, Vol., , DOI:10.32604/sdhm.2023.025989

Abstract As a critical structure of aerospace equipment, aluminum alloy stiffened plate will influence the stability of spacecraft in orbit and the normal operation of the system. In this study, a GWO-ELM algorithm-based impact damage identification method is proposed for aluminum alloy stiffened panels to monitor and evaluate the damage condition of such stiffened panels of spacecraft. Firstly, together with numerical simulation, the experimental simulation to obtain the damage acoustic emission signals of aluminum alloy reinforced panels is performed, to establish the damage data. Subsequently, the amplitude-frequency characteristics of impact damage signals are extracted and put into an extreme learning machine… More >

Jian Ai¹, Jie Xue^1,*, Jiabang Yu^1,2, Xinyu Huang², Pan Wei^1,2, Xiaohu Yang², Bengt Sundén^3,*

Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2023.045134

Abstract The calculation of heat and humidity load serves as the cornerstone of Heating, Ventilation, and Air Conditioning (HVAC) design. Nevertheless, as the heat and humidity load characteristics of underground structures differ substantially from those of above-ground structures, it is a challenge to derive their accurate calculation procedure through engineering experience. Therefore, it is particularly important to carry out quantitative research on heat and humidity load. This study used Design Builder software to study the influence of the design state point of air conditioning in underground buildings on energy consumption. The study showed that compared with the single design temperature of… More >

Rodrigo Vidonscky Pinto¹, Flávio Augusto Sanzovo Fiorelli^2,*

Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2023.041917

Abstract The present work provides an experimental and numerical procedure to obtain the geometrical position of the hotspots of a microprocessor using the thermal images obtained from the transient thermal response of this processor subject to pulsating stress tests. This is performed by the solution of the steady inverse heat transfer problem using these thermal images, resulting in qualitative heat source distributions; these are analyzed using the mean heat source gradients to identify the elements that can be considered hotspots. This procedure identified that the processor INTEL Core 2 Quad Q8400S contains one hotspot located in the center of its left… More >

Håvard Bjerkeseth Solvin^1,2,5,*, Simone Goa Diab^1,4, Ole Jakob Elle^2,3, Henrik Holmstrøm^1,4, Henrik Brun^2,4,*

Congenital Heart Disease, Vol., , DOI:10.32604/chd.2023.031537

Abstract Background: The management of suspected critical congenital heart defects (CCHD) relies on timely echocardiographic diagnosis. The availability of experienced echocardiographers is limited or even non-existent in many hospitals with obstetric units. This study evaluates remote-mentored echocardiography performed by physicians without experience in imaging of congenital heart defects (CHD). Methods: The setup included a pediatric cardiologist in a separate room, guiding a physician without experience in echocardiographic imaging of CHD in the examination of a symptomatic newborn. This remote-mentoring pair was blinded to the diagnosis of the newborn and presented with a simplified patient history. The echocardiographic images were streamed to… More >