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  • Open Access

    ARTICLE

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

    XIANBAO FANG1,#, MINGYAN TANG1,#, ZIYANG YU1,#, JIAQI DING1, CHONG CUI2, HONG ZHANG1,*

    BIOCELL, Vol., , DOI:10.32604/biocell.2023.030565

    Abstract Objective: Key genes were screened to analyze molecular mechanisms and their drug targets of endometriosis by applying a bioinformatics approach. Methods: Gene expression profiles of endometriosis and healthy controls were obtained from the Gene Expression Omnibus database. Significant differentially expressed genes were screened using the limma package. Correlation pathways were screened by Spearman correlation analysis on the echinoderm microtubule-associated protein-like 4 (EML4) and enrichment in endometriosis pathways and estimated by the GSVA package. Immune characteristics were assessed by the “ESTIMATE” R package. Potential regulatory pathways were determined by enrichment analysis. The SWISS-MODE website was used in homology modeling with EML4… More >

  • Open Access

    ARTICLE

    Insecticidal Activity and Physicochemical Characterization of Nanoparticles from Foliar Extract of Capsicum chinense

    Arnoldo E. Alfaro-Corres1, Daniel González-Mendoza2, Esaú Ruiz-Sánchez1,*, Carlos Ail-Catzin2, Benjamín Valdez-Salas3, Federico Gutiérrez-Miceli4, Arturo Reyes-Ramírez1, Jacques Fils Pierre1

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.031129

    Abstract This work was carried out to evaluate the insecticidal effect of mono, bi and trimetallic nanoparticles (NPs) from leaf extract of habanero pepper (Capsicum chinense Jacq.) on the red flour beetle (Tribolium castaneum herbst.) and cotton mealybug (Phenacoccus solenopsis Tinsley). The results showed that Cu NPs, Cu/Mn NPs and Zn/Cu NPs had high insecticidal effect against T. castaneum (63%–80% mortality after 96 h). The Cu NPs and Zn/Cu NPs showed also insecticidal effect against P. solenopsis, but to a lesser extent (20%–28% after 96 h). With regards to the physicochemical characterization, Cu NPs had a zeta potential of 21.1 mV,… More >

  • Open Access

    ARTICLE

    Finite Element Method Simulation of Wellbore Stability under Different Operating and Geomechanical Conditions

    Junyan Liu1, Ju Liu1, Yan Wang1, Shuang Liu1, Qiao Wang1, Yihe Du2,*

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.030645

    Abstract The variation of the principal stress of formations with the working and geo-mechanical conditions can trigger wellbore instabilities and adversely affect the well completion. A finite element model, based on the theory of poro-elasticity and the Mohr-Coulomb rock damage criterion, is used here to analyze such a risk. The changes in wellbore stability before and after reservoir acidification are simulated for different pressure differences. The results indicate that the risk of wellbore instability grows with an increase in the production-pressure difference regardless of whether acidification is completed or not; the same is true for the instability area. After acidizing, the… More >

  • Open Access

    ARTICLE

    Analysis of the Flow Field and Impact Force in High-Pressure Water Descaling

    Yue Cui1,*, Liyuan Wang2, Jian Wu1, Haisheng Liu1, Di Wu1

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.030311

    Abstract This study aims to improve the performances of the high-pressure water descaling technology used in steel hot rolling processes. In particular, a 2050 mm hot rolling line is considered, and the problem is investigated by means of a fluid–structure interaction (FSI) method by which the descaling effect produced by rolling coils with different section sizes is examined. Assuming a flat fan-shaped nozzle at the entrance of the R1R2 roughing mill, the out- flow field characteristics and the velocity distribution curve on the strike line (at a target distance of 30–120 mm) are determined. It is found that the velocity in… More >

  • Open Access

    ARTICLE

    Experimental and Numerical Investigation on the Aerodynamic Characteristics of High-Speed Pantographs with Supporting Beam Wind Deflectors

    Shiyang Song1,*, Tongxin Han2

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.030137

    Abstract Aiming to mitigate the aerodynamic lift force imbalance between pantograph strips, which exacerbates wear and affects the current collection performance of the pantograph-catenary system, a study has been conducted to support the beam deflector optimization using a combination of experimental measurements and computational fluid dynamics (CFD) simulations. The results demonstrate that the size, position, and installation orientation of the wind deflectors significantly influence the amount of force compensation. They also indicate that the front strip deflectors should be installed downwards and the rear strip deflectors upwards, thereby forming a “π” shape. Moreover, the lift force compensation provided by the wind… More >

  • Open Access

    ARTICLE

    Evaluation of the Air Leakage Flowrate in Sintering Processes

    Jin Cai1, Xiangwei Kong1,*, Mingzhu Yu1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.029692

    Abstract Iron ore sintering is a pre-treatment technology by which ore fines are converted into porous and permeable sinters, which are the used in blast furnaces. This process can be adversely affected by air leakage phenomena of various types. As experimental measurements are relatively difficult and often scarcely reliable, here a theoretical model based on typical fluid-dynamic concepts and relationships is elaborated. Through the analysis of two extreme cases, namely, those in which leakage is due to a small hole or a full rupture, a generalized hole-bed model is introduced, which for the first time also includes a complete bed permeability… More >

  • Open Access

    ARTICLE

    Simulation of Moving Bed Erosion Based on the Weakly Compressible Smoothed Particle Hydrodynamics-Discrete Element Coupling Method

    Qingyun Zeng1,2, Mingxin Zheng1,*, Dan Huang2

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.029427

    Abstract A complex interface exists between water flow and solid particles during hydraulic soil erosion. In this study, the particle discrete element method (DEM) has been used to simulate the hydraulic erosion of a granular soil under moving bed conditions and surrounding terrain changes. Moreover, the weakly compressible smoothed particle hydrodynamics (WCSPH) approach has been exploited to simulate the instability process of the free surface fluid and its propagation characteristics at the solid–liquid interface. The influence of a suspended medium on the water flow dynamics has been characterized using the mixed viscosity concept accounting for the solid–liquid mixed particle volume ratio.… More >

  • Open Access

    ARTICLE

    Assessment of Nanoparticle-Enriched Solvents for Oil Recovery Enhancement

    Muayad M. Hasan1,*, Firas K. Al-Zuhairi2, Anfal H. Sadeq1, Rana A. Azeez1

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.027746

    Abstract Solvents are generally used to reduce the viscosity of heavy crude oil and ultimately enhance oil recovery. Recently, a new method has been introduced where nanoparticles (NPs) are exploited to induce enhanced oil recovery owing to their ability to improve the mobility ratio, dampen the interfacial tension, and alter rock wettability. This study investigated the integration of nano-alumina (Al2O3) NPs with an n-hexane solvent. In particular, a Brookfield viscometer has been used to measure the crude oil viscosity and it has been found that NPs can effectively lead to a significant decrease in the overall oil viscosity (70 cp using… More >

  • Open Access

    ARTICLE

    Numerical Simulation of Turbulent Diffusion Flames of a Biogas Enriched with Hydrogen

    Naima Krarraz1,*, Amina Sabeur1, Khadidja Safer2, Ahmed Ouadha1

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.026238

    Abstract Any biogas produced by the anaerobic fermentation of organic materials has the advantage of being an environmentally friendly biofuel. Nevertheless, the relatively low calorific value of such gases makes their effective utilization in practical applications relatively difficult. The present study considers the addition of hydrogen as a potential solution to mitigate this issue. In particular, the properties of turbulent diffusion jet flames and the related pollutant emissions are investigated numerically for different operating pressures. The related numerical simulations are conducted by solving the RANS equations in the frame of the Reynolds Stress Model in combination with the flamelet approach. Radiation… More >

  • Open Access

    ARTICLE

    CFD-Based Optimization of a Shell-and-Tube Heat Exchanger

    Juanjuan Wang*, Jiangping Nan, Yanan Wang

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.021175

    Abstract The main objective of this study is the technical optimization of a Shell-and-Tube Heat Exchanger (STHE). In order to do so, a simulation model is introduced that takes into account the related gas-phase circulation. Then, simulation verification experiments are designed in order to validate the model. The results show that the temperature field undergoes strong variations in time when an inlet wind speed of 6 m/s is considered, while the heat transfer error reaches a minimum of 5.1%. For an inlet velocity of 9 m/s, the heat transfer drops to the lowest point, while the heat transfer error reaches a… More >

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