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E3 Ligases and COVID-19: Insights into Viral Control and Therapeutic Potential

by Mukul Mishra1, Deeba Khan2, Sehbanul Islam1,*

1 Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2 Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India

* Corresponding Author: Sehbanul Islam. Email: email

(This article belongs to the Special Issue: Functional Interactions Between Viral Proteins and Cellular Mechanisms)

BIOCELL 2025, 49(1), 127-147. https://doi.org/10.32604/biocell.2025.058038

Abstract

The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their modulation by E3 ubiquitin ligases. By dissecting these intricate interactions and the impact of E3 ligases on SARS-CoV-2 infection, we aim to uncover novel therapeutic opportunities and strategies to effectively combat COVID-19.

Keywords


Cite This Article

APA Style
Mishra, M., Khan, D., Islam, S. (2025). E3 ligases and COVID-19: insights into viral control and therapeutic potential. BIOCELL, 49(1), 127–147. https://doi.org/10.32604/biocell.2025.058038
Vancouver Style
Mishra M, Khan D, Islam S. E3 ligases and COVID-19: insights into viral control and therapeutic potential. BIOCELL. 2025;49(1):127–147. https://doi.org/10.32604/biocell.2025.058038
IEEE Style
M. Mishra, D. Khan, and S. Islam, “E3 Ligases and COVID-19: Insights into Viral Control and Therapeutic Potential,” BIOCELL, vol. 49, no. 1, pp. 127–147, 2025. https://doi.org/10.32604/biocell.2025.058038



cc Copyright © 2025 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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