Open Access
REVIEW
E3 Ligases and COVID-19: Insights into Viral Control and Therapeutic Potential
1 Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2 Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India
* Corresponding Author: Sehbanul Islam. Email:
(This article belongs to the Special Issue: Functional Interactions Between Viral Proteins and Cellular Mechanisms)
BIOCELL 2025, 49(1), 127-147. https://doi.org/10.32604/biocell.2025.058038
Received 03 September 2024; Accepted 09 December 2024; Issue published 24 January 2025
Abstract
The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their modulation by E3 ubiquitin ligases. By dissecting these intricate interactions and the impact of E3 ligases on SARS-CoV-2 infection, we aim to uncover novel therapeutic opportunities and strategies to effectively combat COVID-19.Keywords
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