SUYING PU^1,#, HUI ZHENG^2,#, YUN TAO¹, JING SHAO¹, MINGNA YANG¹, SHUNJUN LI^1,*

BIOCELL, Vol.46, No.6, pp. 1545-1555, 2022, DOI:10.32604/biocell.2022.017544

Abstract Intracerebral hemorrhage (ICH) is the most serious type of stroke. High level of thrombin is found in the ICH. Ubiquitin-specific protease (USP) 31, a member of deubiquitinating enzymes family, has been found to negatively regulate the NF-κB pathway. However, the function of USP31 in ICH remains largely unknown. In the present study, the mRNA and protein expression levels of USP31 were measured by real-time PCR and western blot. Flow cytometry was used to measure cell apoptosis and the level of reactive oxygen species (ROS). In the current study, we found the mRNA level of USP31 was decreased in peripheral blood… More >

JIAN XU^1,#, HAILONG GE^1,#, CHEN CHAO¹, FENG MO¹, YU WANG¹, DENGKUI ZHANG¹, XIAOXIAO ZHENG², LI ZHENG², XUEMEI LU², WEI CHEN², QUN XU^1,*, WEIXIN YU^1,*

BIOCELL, Vol.46, No.6, pp. 1493-1503, 2022, DOI:10.32604/biocell.2022.016962

Abstract Although sorafenib has been found to prolong the survival time of patients with hepatocellular carcinoma (HCC), sorafenib resistance remains an important challenge. Increasing studies have demonstrated that long noncoding RNAs (lncRNAs) contribute to drug resistance in a wide number of cancers. Human periodontal ligament stem cell (PDLSC) osteogenesis impairment-related lncRNA (POIR) is a recently defined lncRNA for which little is known regarding its function. Our study aimed to reveal the role of POIR in the development of HCC cell sorafenib resistance. The level of POIR expression in patients and tumor cells was examined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR)… More >

BIOCELL, Vol.46, Suppl.1, pp. 1-198, 2022

Abstract This article has no abstract. More >

JONG HWAN SUNG^*

BIOCELL, Vol.46, No.5, pp. 1177-1180, 2022, DOI:10.32604/biocell.2022.019055

Abstract Organ-on-a-chip technology aims to reproduce the key physiological features of human organs and tissues, even complex actions of multi-organ interaction. While organ-on-a-chips at single-organ level has made notable achievement during the last decade, multi-organ-on-a-chips, which manifests unique advantages, has started gathering attention only recently. In this viewpoint, we discuss the current status of organ-on-a-chip technology, with a specific emphasis on multi-organ-on-a-chip. Key technological advances contributing to the maturation of the field, and challenges that need to be addressed before wider adoption in relevant fields are discussed. We will share our perspectives on how the multi-organ-on-a-chip can improve the drug development… More >

YUKI MATSUSHITA, WANIDA ONO, NORIAKI ONO^*

BIOCELL, Vol.46, No.5, pp. 1157-1162, 2022, DOI:10.32604/biocell.2022.018960

Abstract Single-cell sequencing technologies have rapidly progressed in recent years, and been applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are generally identified using combinations of cell surface markers and transcription factors. However, it has been challenging to define micro-heterogeneity within “stem cell” populations, each of which stands at a different level of differentiation. As stem cells become defined at a single-cell level, their differentiation path becomes clearly defined. Here, this viewpoint discusses the potential synergy of single-cell sequencing analyses with in vivo lineage-tracing approaches, with an emphasis on practical considerations in stem cell biology. More >

FENGJUN DAI¹, ZIYI RONG¹, QIANGSHENG WU¹, ELSAYED FATHI ABD_ALLAH³, CHUNYAN LIU^1,2,*, SHENGRUI LIU^2,*

BIOCELL, Vol.46, No.5, pp. 1339-1346, 2022, DOI:10.32604/biocell.2022.018909

Abstract Tea plants are sensitive to soil moisture deficit, with the level of soil water being a critical factor affecting their growth and quality. Arbuscular mycorrhizal fungi (AMF) can improve water and nutrient absorption, but it is not clear whether AMF can improve the photosynthetic characteristics of tea plants. A potted study was conducted to determine the effects of Claroideoglomus etunicatum on plant growth, leaf water status, pigment content, gas exchange, and chlorophyll fluorescence parameters in Camellia sinensis cv. Fuding Dabaicha under well-watered (WW) and drought stress (DS) conditions. Root mycorrhizal colonization and soil hyphal length were significantly reduced by the… More >

GIUSEPPINA AMODIO¹, VALENTINA PAGLIARA¹, PAOLO REMONDELLI^1,*, ORNELLA MOLTEDO²

BIOCELL, Vol.46, No.5, pp. 1131-1137, 2022, DOI:10.32604/biocell.2022.018638

Abstract The endoplasmic reticulum (ER) is the site of entry of all proteins that function in the secretory pathway including the extracellular environment. Because it controls the folding of newly synthesized secretory proteins, the ER is indispensable for the maintenance of proteostasis in the secretory pathway. Within the ER and, in part, in post-ER compartments, the quality control of protein folding is under the regulation of the unfolded protein response (UPR) pathways. The UPR strategy is to enhance protein folding, increase the ER degradation pathway of misfolded proteins, and allow the exit from the ER of only correctly folded proteins. The… More >

AMANDA BARACHO TRINDADE HILL^1,2,*, JONATHAN EDWIN BARACHO TRINDADE HILL²

BIOCELL, Vol.46, No.5, pp. 1173-1176, 2022, DOI:10.32604/biocell.2022.018637

Abstract Mesenchymal stem cells (MSCs) represent an important tool in veterinary regenerative medicine due to their ability to home to injury sites and secrete molecules that regulate niches into regenerative microenvironments. Successful cell therapy depends on many factors, including choice of administration route and application of understanding of cell potency and their therapeutic mechanisms. In this point of view, the authors leverage the tumultuous history of the field to demonstrate the need for clinicians to continually update themselves as new discoveries are made in order to avoid misalignments in the future, especially regarding administration routes and dose frequency, as well as… More >

MICHAEL HUBER^*, SANDRO CAPELLMANN

BIOCELL, Vol.46, No.5, pp. 1125-1129, 2022, DOI:10.32604/biocell.2022.018513

Abstract Mast cells (MCs), hematopoietic cells of the myeloid lineage, are well-known for their pro-inflammatory nature contributing to the development of various allergic and autoimmune diseases. One of the characteristic receptors on MCs, the high-affinity receptor for IgE (FcεRI), is activated in its IgE-bound state via binding and crosslinking by polyvalent antigen. This results in its phosphorylation by the SRC family kinase LYN, initiating differential signaling pathways, eventually triggering immunological effector functions, such as degranulation and cytokine production. Few publications have reported on FcεRI-dependent but antigen-independent MC activation by antibody-mediated crosslinking of membrane molecules (e.g., transmembrane proteins and glycosphingolipids) that are… More >

DICKSON KOFI WIREDU OCANSEY^1,2,*, XINWEI XU¹, LU ZHANG¹, FEI MAO^1,*

BIOCELL, Vol.46, No.5, pp. 1169-1172, 2022, DOI:10.32604/biocell.2022.018470

Abstract Stem cell research is a promising area of transplantation and regenerative medicine with tremendous potential for improving the clinical treatment and diagnostic options across a variety of conditions and enhancing understanding of human development. Over the past few decades, mesenchymal stem cell (MSCs) studies have exponentially increased with a promising outcome. However, regardless of the huge investment and the research attention given to stem cell research, FDA approval for clinical use is still lacking. Amid the challenges confronting stem cell research as a cell-based product, there appears to be evidence of superior effect and heightened potential success in its expressed… More >