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  • Open Access


    Ultrastructural analysis shows persistence of adhesion and tight junction proteins in mature human hair


    BIOCELL, Vol.45, No.4, pp. 1013-1022, 2021, DOI:10.32604/biocell.2021.013913

    Abstract The differentiation of cells composing mature human hairs produces layers with different corneous characteristics that would tend to flake away one from another, as in the corneous layer of the epidermis, without anchoring junctions. It is likely that cell junctions established in the forming cells of the hair bulb are not completely degraded like in the corneous layer of the epidermis but instead remain in the hair shaft to bind mature cuticle, cortex, and medulla cells into a compact hair shaft. During cell differentiation in hairs, cell junctions seem to disappear, and little is known… More >

  • Open Access


    Dynamic Characteristics Analysis of Ice-Adhesion Transmission Tower-Line System under Effect of Wind-Induced Ice Shedding

    Yongping Yu1, Lihui Chen1, Juanjuan Wang1, Guoji Liu2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.2, pp. 647-670, 2020, DOI:10.32604/cmes.2020.011067

    Abstract The tower line system will be in an unsafe status due to uniform or uneven fall of ice coating which is attached to the surface of tower and lines. The fall of ice could be caused by wind action or thermal force. In order to study the dynamic characteristics of the self-failure of the transmission line under the action of dynamic wind load, a finite element model of the two-span transmission tower line system was established. The birth and death element methods are used to simulate the icing and shedding of the line. Tensile failure… More >

  • Open Access


    Improving Interfacial Adhesion of PLA/Lignin Composites by One-Step Solvent-Free Modification Method

    Ningning Wang1, Caili Zhang1,2,*, Wenqin Zhu3, Yunxuan Weng1,2,*

    Journal of Renewable Materials, Vol.8, No.9, pp. 1139-1149, 2020, DOI:10.32604/jrm.2020.09961

    Abstract To clarify the effects of lignin as a biodegradable filler added into the PLA matrix, PLA/lignin composites with or without silane coupling agent of γ- (2,3-epoxypropoxy)propy trimethoxysilane (KH560) were prepared by a one-step solvent-free modification method. The effects of KH560 as a compatibilizer on the morphology, chemical structure, crystallization behavior, thermal degradative behavior as well as mechanical strength of the PLA/lignin composites were analyzed in detail. It was found that, after modification by KH560, the fractured surfaces of composites became smooth, suggested sufficient bonding between the lignin and PLA in the composites with KH560 coupling… More >

  • Open Access


    The roles of focal adhesion and cytoskeleton systems in fluid shear stress-induced endothelial cell response


    BIOCELL, Vol.44, No.2, pp. 137-145, 2020, DOI:10.32604/biocell.2020.08500

    Abstract Focal adhesions are polyproteins linked to extracellular matrix and cytoskeleton, which play an important role in the process of transforming force signals into intracellular chemical signals and subsequently triggering related physiological or pathological reactions. The cytoskeleton is a network of protein fibers in the cytoplasm, which is composed of microfilaments, microtubules, intermediate filaments, and cross-linked proteins. It is a very important structure for cells to maintain their basic morphology. This review summarizes the process of fluid shear stress transduction mediated by focal adhesion and the key role of the cytoskeleton in this process, which focuses More >

  • Open Access


    Poly (vinyl alcohol)/Graphene Nanocomposite Hydrogel Scaffolds for Control of Cell Adhesion

    Xiaodong Wang1,2, Meng Su2, Chuntai Liu2, Changyu Shen2, Xianhu Liu2,*

    Journal of Renewable Materials, Vol.8, No.1, pp. 89-99, 2020, DOI:10.32604/jrm.2020.08493

    Abstract Poly (vinyl alcohol) (PVA)/reduced graphene oxide (rGO) nanocomposites is prepared by the immersion of PVA/graphene oxide (GO) nanocomposites in the reducing agent aqueous solution. The PVA/graphene nanocomposites can be used as scaffold after treatment by chemical crosslinking agents. The surface hydrophilicity of the nanocomposite scaffolds decreased with the addition of GO or rGO by measuring the contact angles of scaffolds. The electrical conductivity of PVA/rGO nanocomposite scaffold increased with rGO content increased. The highest conductivity of PVA/rGO nanocomposite scaffolds with 10 wt% rGO could reach to 12.16 × 10−3 S/m. The NIH-3T3 fibroblasts attach and grow More >

  • Open Access


    Tissue expression of platelet endothelial cell adhesion molecule-1 at pre and postnatal murine development


    BIOCELL, Vol.28, No.3, pp. 251-258, 2004, DOI:10.32604/biocell.2004.28.251

    Abstract Endothelial cells, at the cell-cell borders, express PECAM-1, and have been implicated in vascular functions. The monoclonal antibody MEC 13.3 recognizes PECAM-1 molecule from mouse vessels and allows to analyze the ontogeny of mouse endothelium. At the present, little is known about the molecular basis of differentiation pathways of endothelial cells, that enables its morphological heterogeneity. The purpose of this study was to analyze the pattern of PECAM-1 expression, employing monoclonal antibody MEC 13.3, in cellular suspensions obtained from different mouse organs at pre and postnatal stages.
    Fluorescence activated cell sorter analysis showed a different… More >

  • Open Access


    Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins

    T.H. Satoh2, T.A. Surmacz3, O. Nyormoi4, C.M. Whitacre1

    BIOCELL, Vol.27, No.1, pp. 47-55, 2003, DOI:10.32604/biocell.2003.27.047

    Abstract This study shows a strong association between cell attachment to substratum and activation of β1-integrin-signaling with resistance to the camptothecin derivative topotecan (TPT) in breast cancer cells. We propose a mechanistic-driven approach to sensitize the cells to camptothecins. ZR-75-1 anchoragedependent breast cancer cell line, its derivative 9D3S suspension cells (9D3S-S), and 9D3S cells attached to fibronectin-coated plates (9D3S-A) were treated with TPT (1 µM) or CPT-11 (40 µM) for 48 h. Programmed cell death (PCD), as shown by poly(ADP-ribose) polymerase (PARP), pro-caspase-3 and pro-caspase-9 cleavage, was observed in 9D3S-S cells but not in ZR-75-1 or More >

  • Open Access


    Fast Force Loading Disrupts Molecular Bond Stability in Human and Mouse Cell Adhesions

    Yunfeng Chen1,2,3,†,*, Jiexi Liao4,†, Zhou Yuan1, Kaitao Li4, Baoyu Liu4, Lining Arnold Ju4,5,6, Cheng Zhu1,2,4,5,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 97-97, 2019, DOI:10.32604/mcb.2019.07123

    Abstract Force-mediated molecular binding initiates numerous cellular activities such as cell adhesion, migration, and activation. Dynamic force spectroscopy (DFS) is widely used to examine molecular binding and cell mechano-signaling [1]. The rate of dissociation, off-rate, is an important attribute of molecular binding that reflects bond stability. Extensive DFS works have demonstrated that off-rates are a function of force magnitude, yielding signature bond behaviors like “catch bond” [2]. However, as a controversial topic of the field, different DFS assays, i.e., force-clamp and force-ramp assays, often yielded distinctive "off-rate vs. force" relations from the same molecular system [3].… More >

  • Open Access


    Shear Force at the Cell-Matrix Interface: Enhanced Analysis for Microfabricated Post Array Detectors

    Christopher A. Lemmon1,2, Nathan J. Sniadecki3, Sami Alom Ruiz1,3, John L. Tan, Lewis H. Romer2,4,5, Christopher S. Chen3,4

    Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 1-16, 2005, DOI:10.3970/mcb.2005.002.001

    Abstract The interplay of mechanical forces between the extracellular environment and the cytoskeleton drives development, repair, and senescence in many tissues. Quantitative definition of these forces is a vital step in understanding cellular mechanosensing. Microfabricated post array detectors (mPADs) provide direct measurements of cell-generated forces during cell adhesion to extracellular matrix. A new approach to mPAD post labeling, volumetric imaging, and an analysis of post bending mechanics determined that cells apply shear forces and not point moments at the matrix interface. In addition, these forces could be accurately resolved from post deflections by using images of More >

  • Open Access


    Force-induced Unfolding of the Focal Adhesion Targeting Domain and the Influence of Paxillin Binding

    M.R. Kaazempur Mofrad1,2, J. Golji2, N.A. Abdul Rahim2, R.D. Kamm3

    Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 253-266, 2004, DOI:10.3970/mcb.2004.001.253

    Abstract Membrane-bound integrin receptors are linked to intracellular signaling pathways through focal adhesion kinase (FAK). FAK tends to colocalize with integrin receptors at focal adhesions through its C-terminal focal adhesion targeting (FAT) domain. Through recruitment and binding of intracellular proteins, FAs transduce signals between the intracellular and extracellular regions that regulate a variety of cellular processes including cell migration, proliferation, apoptosis and detachment from the ECM. The mechanism of signaling through the cell is of interest, especially the transmission of mechanical forces and subsequent transduction into biological signals. One hypothesis relates mechanotransduction to conformational changes in More >

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