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  • Open Access

    VIEWPOINT

    Junctional adhesion molecule-A (JAM-A) in gynecological cancers: Current state of knowledge

    KAMILA CZUBAK-PROWIZOR*, MARIA SWIATKOWSKA

    BIOCELL, Vol.47, No.4, pp. 731-737, 2023, DOI:10.32604/biocell.2023.025677

    Abstract Junctional adhesion molecule-A (JAM-A), also known as the F11 receptor (F11R), is one of the tight junction components. JAM-A is a transmembrane glycoprotein that regulates many cellular processes, i.e., angiogenesis, leukocyte transendothelial migration, intercellular permeability, epithelial-to-mesenchymal transition, and platelet activation. Of note, it is involved in the pathogenesis of various cancer types, including gynecological cancers. Only a few studies are available about this cancer type. Observed aberrant JAM-A expression in gynecological cancers correlates with poor patient prognosis. To the best of our knowledge, conflicting JAM-A roles in various cancer types suggest that its involvement is More >

  • Open Access

    ARTICLE

    FPGA Implementation of Extended Kalman Filter for Parameters Estimation of Railway Wheelset

    Khakoo Mal1,2,*, Tayab Din Memon1,3, Imtiaz Hussain Kalwar4, Bhawani Shankar Chowdhry5

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3351-3370, 2023, DOI:10.32604/cmc.2023.032940

    Abstract It is necessary to know the status of adhesion conditions between wheel and rail for efficient accelerating and decelerating of railroad vehicle. The proper estimation of adhesion conditions and their real-time implementation is considered a challenge for scholars. In this paper, the development of simulation model of extended Kalman filter (EKF) in MATLAB/Simulink is presented to estimate various railway wheelset parameters in different contact conditions of track. Due to concurrent in nature, the Xilinx® System-on-Chip Zynq Field Programmable Gate Array (FPGA) device is chosen to check the onboard estimation of wheel-rail interaction parameters by using the… More >

  • Open Access

    REVIEW

    Surface activity of cancer cells: The fusion of two cell aggregates

    IVANA PAJIC-LIJAKOVIC*, MILAN MILIVOJEVIC

    BIOCELL, Vol.47, No.1, pp. 15-25, 2023, DOI:10.32604/biocell.2023.023469

    Abstract A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out… More >

  • Open Access

    ARTICLE

    Mechanical Properties, Biocompatibility and Anti-Bacterial Adhesion Property Evaluation of Silicone-Containing Resin Composite with Different Formulae

    Muzi Liao1,2,#, Hui Tong1,2,#, Xiangya Huang1,2, Fang Liu3, Jingwei He3,*, Sui Mai1,2,*

    Journal of Renewable Materials, Vol.10, No.12, pp. 3201-3215, 2022, DOI:10.32604/jrm.2022.022090

    Abstract Novel branched silicone methacrylate was developed. The mechanical and biological properties of the resin system were investigated to select the formula proportion with the best overall performance. The novel silicone-containing monomers were combined with an incremental sequence of glass filler concentrations in commonly used Bis-GMA/TEGDMA (50/50, wt./wt.) dental resin systems. Physicochemical properties, surface properties, antibacterial adhesion effect, anti-biofilm effect, protein adsorption, and cytotoxicity were evaluated. The results showed that BSMs did not affect the double bond conversion of dental resin, but could reduce volumetric shrinkage (p < 0.05). The BSM containing resins can resist protein and… More >

  • Open Access

    REVIEW

    Biomechanics of transendothelial migration by cancer cells

    CLAUDE VERDIER*

    BIOCELL, Vol.46, No.11, pp. 2381-2386, 2022, DOI:10.32604/biocell.2022.021368

    Abstract Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their growth. In addition the formation of metastases is very difficult to understand, since it involves very complex physical mechanisms such as cellular interactions and cell rheology, which are flow-dependent. Previous studies investigated transendothelial migration using sophisticated techniques such as microfluidics, traction force microscopy (TFM) or Atomic Force Microscopy (AFM), combined with physical modeling. Here we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration. More >

  • Open Access

    ARTICLE

    The Effect of Printing Parameters and Wood Surface Preparation on the Adhesion of Directly 3D-Printed PLA on Wood

    Daša Krapež Tomec, Angela Balzano, Jure Žigon, Milan Šernek, Mirko Kariž*

    Journal of Renewable Materials, Vol.10, No.7, pp. 1787-1796, 2022, DOI: 10.32604/jrm.2022.019760

    Abstract As additive manufacturing technologies advance, new opportunities are opening up for their application in the furniture industry. Wood remains one of the leading raw materials in the furniture industry; therefore, possible options for combining it with 3D printing have been researched. The bonding of 3D-printed polymer parts with wood or 3D printing with wood-plastic composites is already known, but in our research we attempted to directly 3D print polylactic acid (PLA) on wood surfaces. The effect of printing parameters, as well as the surface preparation of wood on the shear strength of the bond between… More >

  • Open Access

    VIEWPOINT

    Implant surface features as key role on cell behavior

    RAFAEL SCAF DE MOLON1,2, MARTA MARIA ALVES PEREIRA2, ERICA DORIGATTI DE AVILA2

    BIOCELL, Vol.46, No.5, pp. 1151-1156, 2022, DOI:10.32604/biocell.2022.018026

    Abstract It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix (ECM) that may affect cell behaviors. In nature, ECM is a heterogeneous three-dimensional superstructure formed by three major components, glycosaminoglycan, glycoconjugate, and protein, that anchors cellular compartments in tissues and regulates the function and the behavior of cells. Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors, which, in turn, enable it to trigger specific cell signaling and different cellular responses. In fact, a number of strategies have been used to More >

  • Open Access

    ARTICLE

    Cell adhesion in renal tubular epithelial cells: Biochemistry, biophysics or both

    CLAIRE ELIZABETH HILLS, ELEFTHERIOS SIAMANTOURAS, PAUL EDWARD SQUIRES*

    BIOCELL, Vol.46, No.4, pp. 937-940, 2022, DOI:10.32604/biocell.2022.018414

    Abstract Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and progression. However, these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix, as well as the biophysical and mechanical properties orchestrated by cytoskeletal, membrane and matrix components. To fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function, it is important to consider both biochemical and biophysical attributes of the system being investigated. In this short viewpoint we reflect on our experiences More >

  • Open Access

    VIEWPOINT

    New evidence for a role of Bisphenol A in cell integrity. Implications in the human population

    RAFAEL MORENO-GÓMEZ-TOLEDANO1,*, MARíA I. ARENAS2, ESPERANZA VÉLEZ-VÉLEZ3, RICARDO J. BOSCH1

    BIOCELL, Vol.46, No.2, pp. 305-308, 2022, DOI:10.32604/biocell.2022.017894

    Abstract Bisphenol A (BPA) is a xenoestrogen known for its implications for the endocrine systems and several other organs, including the kidneys. Recent renal studies have shown that BPA can induce alterations of the cytoskeleton and cell adhesion mechanisms such as a podocytopathy with proteinuria and hypertension, alterations involved in the progression of renal diseases. These data and the fact that BPA is known to be present in the urine of almost the entire population strongly suggest the critical need to reevaluate BPA exposures considered safe. More >

  • Open Access

    ARTICLE

    PIWI Interacting RNA-651 Inhibition Transforms the Genetic Features of MCF-7 Breast Cancer Cells

    Çağrı Öner1,* and Ertuğrul Çolak2

    Oncologie, Vol.23, No.3, pp. 393-407, 2021, DOI:10.32604/Oncologie.2021.016958

    Abstract piRNAs are novel members of small non-coding RNAs and have an impact on genetic and epigenetic mechanisms of cells. It was aimed to investigate the role of piR-651 on MCF-7 benign breast cancer cells by focusing on molecular characteristics. Anti-piR-651 was transfected and effects of piR-651 on proliferation, adhesion, and motility of MCF-7 cells were detected after the 24th, 48th, and 72nd hour. Gene expressions of piR-651, Ki-67, MMP-2, ERα, HIF-1α, and hTERT were determined by using RT-PCR. piR-651 inhibition caused the decrease of proliferation, adhesion (p < 0.001), and motility of MCF-7 cells. The efficiency… More >

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