Haitong Zhao¹, Yi Li¹, Shouhua Luo^1,*

Molecular & Cellular Biomechanics, Vol.16, No.4, pp. 265-273, 2019, DOI:10.32604/mcb.2019.07381

Abstract The ring artifacts introduced by the defective pixels with non-linear responses in the high-resolution detector, have a great impact on subsequent processing and quantitative analysis of the reconstructed images. In this paper, a multistep method is proposed to suppress the ring artifacts of micro CT images, which firstly locates the positions of the defective pixels in the sinogram, and then corrects the corresponding value in the projections. Since the defective pixels always appear as vertical stripes in the sinogram, a horizontal curve is derived by summing the pixel values along vertical direction, thus the abrupt segments related to the defective… More >

Bryan Pfister¹, George Oyler², Michael Betenbaugh³, Gang Bao⁴

Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 233-244, 2004, DOI:10.3970/mcb.2004.001.233

Abstract The Bcl-2 family of proteins has recently been implicated as a possible player in the complex cascade of neural cell death due to traumatic brain injuries. However, it is unclear if the Bcl-2 pathways are activated in mechanically injured neurons. Here we report the effects of BclX_L and Bax over-expression on stretch-induced neural cell death using an in vitro uniaxial stretch model of traumatic axonal injury. Specifically, YFP, YFP-tagged Bax and YFP-tagged BclX_L proteins were expressed in differentiated NG108-15 cells and stretch-injury assays were carried out at different strain and strain rate combinations. As a control, insults known to act… More >

Q. Ma^1,2, J. L. Beuth¹, G. H. Meier³, F. S. Pettit³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.8, No.1, pp. 13-18, 2008, DOI:10.3970/icces.2008.008.013

Abstract This paper addresses the mechanics of indentation-induced delamination of a coating on a multi-layered hollow cylinder, for application to toughness testing of thermal barrier coating (TBC) systems. An electron-beam physical vapor deposition (EB-PVD) TBC system has been analyzed through a contact finite element model using a standard conical indenter impressed vertically on the top of the cylinder. Two cylinder sizes used in thermal-mechanical fatigue tests in literature have been considered in the analysis, with outer radii of 5.11 mm and 3.08 mm, and inner radii of 3.00 mm and 0.97 mm, respectively. Two boundary conditions for the inner surface of… More >

Pranav S. Sapkal^1*, Abhaykumar M. Kuthe¹, Divya Ganapathy², Shantanu C. Mathankar³, Sudhanshu Kuthe⁴

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 115-136, 2016, DOI:10.3970/mcb.2016.013.131

Abstract Biphasic calcium phosphate scaffolds with 20/80 HA/TCP ratio were fabricated using the 3D-Bioplotting system to heal critical size defects in rabbit tibia bone. Four different architectures were printed in a layer by layer fashion with lay down patterns viz. (a) 0°– 90°, (b) 0°– 45°– 90°– 135°, (c) 0°–108°– 216° and (d) 0°– 60°– 120°. After high-temperature sintering scaffolds were coated with collagen and were further characterized by (FTIR) Fourier Transform Infrared Spectroscopy, (SEM) Scanning Electron Microscopy, (XRD) X-Ray diffraction, Porosity analysis and Mechanical testing. Scaffold samples were tested for its ability to induce cytotoxicity in Balb/c 3T3 cells at… More >

Hiroshi Yamada^∗,†, Hirokazu Ando^†

Molecular & Cellular Biomechanics, Vol.4, No.1, pp. 1-12, 2007, DOI:10.3970/mcb.2007.004.001

Abstract We investigated the response of apical and basal actin stress fibers (SFs) and its dependency on cell confluency for endothelial cells subjected to cyclic stretching. Porcine aortic endothelial cells from the 2^nd and 5^th passages were transferred to a fibronectin-coated silicone chamber with 5000–8000 cells/cm²(isolated condition), positioning the cells apart, or with 25,000–27,000 cells/cm²(subconfluent condition), allowing cell-to-cell contact. The substrate was stretched cyclically by 0.5 Hz for 2 h with a peak strain on the substrate that was 15% in the stretch direction and –4% in the transverse direction. The actin filaments (AFs) were stained with rhodamine phalloidin and their… More >

Yasunori Yusa¹, Shinobu Yoshimura¹

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.1, pp. 87-104, 2014, DOI:10.3970/cmes.2014.099.087

Abstract To speed up the elastic–plastic analysis of a large-scale model with a crack in which plasticity is observed near the crack, the partitioned coupling method is applied. In this method, the entire analysis model is decomposed into two non-overlapped domains (i.e., global and local domains), and the two domains are analyzed with an iterative method. The cracked local domain is modeled as an elastic–plastic body, whereas the large-scale global domain is modeled as an elastic body. A subcycling technique is utilized for incremental analysis to reduce the number of global elastic analyses. For a benchmark problem with 6 million degrees… More >

L. Dong¹, A. Alotaibi², S.A. Mohiuddine², S. N. Atluri³

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.1, pp. 1-85, 2014, DOI:10.3970/cmes.2014.099.001

Abstract In this expository article, a variety of computational methods, such as Collocation, Finite Volume, Finite Element, Boundary Element, MLPG (Meshless Local Petrov Galerkin), Trefftz methods, and Method of Fundamental Solutions, etc., which are often used in isolated ways in contemporary literature are presented in a unified way, and are illustrated to solve a 4^th order ordinary differential equation (beam on an elastic foundation). Both the primal formulation, which considers the 4^th order ODE with displacement as the primitive variable, as well as two types of mixed formulations (one resulting in a set of 2 second-order ODEs, and the other resulting… More >

S.A. Khuri¹, A. Sayfy¹

CMES-Computer Modeling in Engineering & Sciences, Vol.101, No.2, pp. 81-96, 2014, DOI:10.3970/cmes.2014.101.081

Abstract In this article, we introduce a numerical scheme to solve a class of nonlinear two-point BVPs on a semi-infinite domain that arise in engineering applications and the physical sciences. The strategy is based on replacing the boundary condition at infinity by an asymptotic boundary condition (ABC) specified over a finite interval that approaches the given value at infinity. Then, the problem complimented with the resulting ABC is solved using a fourth order spline collocation approach constructed over uniform meshes on the truncated domain. A number of test examples are considered to confirm the accuracy, efficient treatment of the boundary condition… More >

G. Kosec^1,2, P. Zinterhof³

CMES-Computer Modeling in Engineering & Sciences, Vol.91, No.5, pp. 377-396, 2013, DOI:10.3970/cmes.2013.091.377

Abstract This paper deals with the implementation of the local meshless numerical method (LMM) on general purpose graphics processing units (GPU) in solving partial differential equations (PDE). The local meshless solution procedure is formulated in a way suitable for parallel execution and has been implemented on multiple GPUs. The implementation is tested on a solution of diffusion equation in a 2D domain. Different setups of the meshless approach regarding the selection of basis functions are tested on an interval up to 2.5 million of computational points. It is shown that monomials are a good selection of the basis when working with… More >

A. N. Guz, V. A. Dekret¹

CMES-Computer Modeling in Engineering & Sciences, Vol.13, No.3, pp. 165-170, 2006, DOI:10.3970/cmes.2006.013.165

Abstract Stability problem of composite material reinforced by two parallel short fibers is solved. The problem is formulated with application of equations of linearized three-dimensional theory of stability. The composite is modeled as piecewise-homogeneous medium. The influence of geometrical and mechanical parameters of the material on critical strain is investigated. More >