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  • Open Access

    REVIEW

    The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

    PARISA SHIRI AGHBASH1,2,4, NIMA HEMMAT1, BEHZAD BARADARAN1,3, AHAD MOKHTARZADEH1, VAHDAT POORTAHMASEBI2,4, MAHIN AHANGAR OSKUEE2,4, HOSSEIN BANNAZADEH BAGHI1,2,4,*

    Oncology Research, Vol.30, No.3, pp. 99-116, 2022, DOI:10.32604/or.2022.026776

    Abstract Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to the development of cervical cancer… More > Graphic Abstract

    The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

  • Open Access

    ARTICLE

    Biomechanical Response of the Root System in Tomato Seedlings under Wind Disturbance

    Zhengguang Liu1, Jun Yang1, Tobi Fadiji2, Zhiguo Li1,*, Jiheng Ni3

    Phyton-International Journal of Experimental Botany, Vol.92, No.4, pp. 1071-1090, 2023, DOI:10.32604/phyton.2023.026408

    Abstract Wind disturbance as a green method can effectively prevent the overgrowth of tomato seedlings, and its mechanism may be related to root system mechanics. This study characterized the biophysical mechanical properties of taproot and lateral roots of tomato seedlings at five seedling ages and seedling substrates with three different moisture content. The corresponding root system-substrate finite element (FE) model was then developed and validated. The study showed that seedling age significantly affected the biomechanical properties of the taproot and lateral roots of the seedlings and that moisture content significantly affected the biomechanical properties of the seedling substrate (p < 0.05).… More >

  • Open Access

    ARTICLE

    Leaching Fraction (LF) of Irrigation Water for Saline Soils Using Machine Learning

    Rab Nawaz Bashir1, Imran Sarwar Bajwa2, Muhammad Waseem Iqbal3,*, Muhammad Usman Ashraf4, Ahmed Mohammed Alghamdi5, Adel A. Bahaddad6, Khalid Ali Almarhabi7

    Intelligent Automation & Soft Computing, Vol.36, No.2, pp. 1915-1930, 2023, DOI:10.32604/iasc.2023.030844

    Abstract Soil salinity is a serious land degradation issue in agriculture. It is a major threat to agriculture productivity. Extra irrigation water is applied to leach down the salts from the root zone of the plants in the form of a Leaching fraction (LF) of irrigation water. For the leaching process to be effective, the LF of irrigation water needs to be adjusted according to the environmental conditions and soil salinity level in the form of Evapotranspiration (ET) rate. The relationship between environmental conditions and ET rate is hard to be defined by a linear relationship and data-driven Machine learning (ML)… More >

  • Open Access

    ARTICLE

    Experimental Investigation on Fracture Performance of Short Basalt Fiber Bundle Reinforced Concrete

    Jinggan Shao1,2, Jiao Ma1, Renlong Liu1, Ye Liu3, Pu Zhang1,*, Yi Tang4, Yunjun Huang2

    Structural Durability & Health Monitoring, Vol.16, No.4, pp. 291-305, 2022, DOI:10.32604/sdhm.2022.015097

    Abstract In this paper, a notched three-point bending test is used to study the fracture performance of the short basalt fiber bundle reinforced concrete (SBFBRC). To compare and analyze the enhancement effect of different diameters and different content of basalt fiber bundles on the fracture performance of concrete, some groups are set up, and the P-CMOD curves of each group of specimens are measured, and the fracture toughness and fracture energy of each control group are calculated. The fracture toughness and fracture energy are two important fracture performance parameters to study the effect and law of the new basalt fiber bundles… More >

  • Open Access

    ARTICLE

    A Novel Efficient Patient Monitoring FER System Using Optimal DL-Features

    Mousa Alhajlah*

    CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6161-6175, 2023, DOI:10.32604/cmc.2023.032505

    Abstract Automated Facial Expression Recognition (FER) serves as the backbone of patient monitoring systems, security, and surveillance systems. Real-time FER is a challenging task, due to the uncontrolled nature of the environment and poor quality of input frames. In this paper, a novel FER framework has been proposed for patient monitoring. Preprocessing is performed using contrast-limited adaptive enhancement and the dataset is balanced using augmentation. Two lightweight efficient Convolution Neural Network (CNN) models MobileNetV2 and Neural search Architecture Network Mobile (NasNetMobile) are trained, and feature vectors are extracted. The Whale Optimization Algorithm (WOA) is utilized to remove irrelevant features from these… More >

  • Open Access

    ARTICLE

    Effect of an Internal Heat Exchanger on the Performances of a Double Evaporator Ejector Refrigeration Cycle

    Rachedi Khadraoui1, Latra Boumaraf1,*, Philippe Haberschill2

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.5, pp. 1115-1128, 2023, DOI:10.32604/fdmp.2022.022674

    Abstract A theoretical investigation is presented about a double evaporator ejector refrigeration cycle (DEERC). Special attention is paid to take into account the influence of the sub-cooling and superheating effects induced by an internal heat exchanger (IHX). The ejector is introduced into the baseline cycle in order to mitigate the throttling process losses and increase the compressor suction pressure. Moreover, the IHX has the structure of a concentric counter-flow type heat exchanger and is intentionally used to ensure that the fluid at the compressor inlet is vapor. To assess accurately the influence of the IHX on the DEERC performance, a mathematical… More > Graphic Abstract

    Effect of an Internal Heat Exchanger on the Performances of a Double Evaporator Ejector Refrigeration Cycle

  • Open Access

    ARTICLE

    Prediction of Flash Flood Susceptibility of Hilly Terrain Using Deep Neural Network: A Case Study of Vietnam

    Huong Thi Thanh Ngo1, Nguyen Duc Dam1, Quynh-Anh Thi Bui1, Nadhir Al-Ansari2,*, Romulus Costache3,4,*, Hang Ha5, Quynh Duy Bui5, Sy Hung Mai6, Indra Prakash7, Binh Thai Pham1

    CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.3, pp. 2219-2241, 2023, DOI:10.32604/cmes.2023.022566

    Abstract Flash floods are one of the most dangerous natural disasters, especially in hilly terrain, causing loss of life, property, and infrastructures and sudden disruption of traffic. These types of floods are mostly associated with landslides and erosion of roads within a short time. Most of Vietnam is hilly and mountainous; thus, the problem due to flash flood is severe and requires systematic studies to correctly identify flood susceptible areas for proper landuse planning and traffic management. In this study, three Machine Learning (ML) methods namely Deep Learning Neural Network (DL), Correlation-based Feature Weighted Naive Bayes (CFWNB), and Adaboost (AB-CFWNB) were… More >

  • Open Access

    ARTICLE

    Efficient-Cost Task Offloading Scheme in Fog-Internet of Vehicle Networks

    Alla Abbas Khadir1, Seyed Amin Hosseini Seno1,2,*, Baydaa Fadhil Dhahir2,3, Rahmat Budiarto4

    Computer Systems Science and Engineering, Vol.45, No.2, pp. 2223-2234, 2023, DOI:10.32604/csse.2023.032316

    Abstract Fog computing became a traditional OffLad Destination (OLD) to compute the offloaded tasks of the Internet of Vehicles (IoV). Nevertheless, the limited computing resources of the fog node leads to re-offload these tasks to the neighboring fog nodes or the cloud. Thus, the IoV will incur additional offloading costs. In this paper, we propose a new offloading scheme by utilizing RoadSide Parked Vehicles (RSPV) as an alternative OLD for IoV. The idle computing resources of the RSPVs can compute large tasks with low offloading costs compared with fog nodes and the cloud. Finally, a performance evaluation of the proposed scheme… More >

  • Open Access

    ARTICLE

    Effects of Hydrothermal Environment on the Deformation of the Thin Bamboo Bundle Veneer Laminated Composites

    Ge Wang, Linbi Chen, Haiying Zhou*, Shanyu Han, Fuming Chen*

    Journal of Renewable Materials, Vol.11, No.3, pp. 1499-1511, 2023, DOI:10.32604/jrm.2022.025130

    Abstract To overcome warping in thin bamboo bundle veneer laminated composites (TBLC), their hydrothermal deformation characteristics were systematically investigated in this study. It was found that TBLCs accelerated the release of internal stress in the thickness direction in a hydrothermal environment, which increased their warpage. TBLCs showed increased warpage in the width and diagonal directions upon increasing the temperature. The warpage of Type E increased by 155.88% and 66.67% in the width and diagonal directions, respectively, when the temperature increased from 25 C to 100 C. The symmetrical TBLC with cross-lay-up and odd layers displayed better hydrothermal stability. We revealed that… More >

  • Open Access

    ARTICLE

    Type-2 Neutrosophic Set and Their Applications in Medical Databases Deadlock Resolution

    Marwan H. Hassan1, Saad M. Darwish2,*, Saleh M. Elkaffas3

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 4417-4434, 2023, DOI:10.32604/cmc.2023.033175

    Abstract Electronic patient data gives many advantages, but also new difficulties. Deadlocks may delay procedures like acquiring patient information. Distributed deadlock resolution solutions introduce uncertainty due to inaccurate transaction properties. Soft computing-based solutions have been developed to solve this challenge. In a single framework, ambiguous, vague, incomplete, and inconsistent transaction attribute information has received minimal attention. The work presented in this paper employed type-2 neutrosophic logic, an extension of type-1 neutrosophic logic, to handle uncertainty in real-time deadlock-resolving systems. The proposed method is structured to reflect multiple types of knowledge and relations among transactions’ features that include validation factor degree, slackness… More >

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