Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (33)
  • Open Access

    ARTICLE

    Ex vivo cartilage explant model for the evaluation of chondrocyte-targeted exosomes

    KAN OUYANG1,2,#, MEIQUAN XU3,#, YUJIE LIANG4, XIAO XU2, LIMEI XU2, CAINING WEN1,2, ZHUAN QIN2, YIXIN XIE2, HUAWEI ZHANG5, LI DUAN2,*, DAPING WANG1,2,5,*

    BIOCELL, Vol.46, No.6, pp. 1521-1526, 2022, DOI:10.32604/biocell.2022.018788 - 07 February 2022

    Abstract There is no efficient tracking system available for the therapeutic molecules delivered to cartilage. The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must overcome. In this study, we aimed to establish a system that can dynamically and effectively track the therapeutic molecules delivered to cartilage. To this aim, we adopted bovine and human cartilage explants as ex vivo models for chondrocyte-targeted exosome dispersion. The efficiency of drug delivery was evaluated using frozen sections. The results of this study showed that the penetration and distribution of chondrocyte-targeted exosomes in More >

  • Open Access

    VIEWPOINT

    MSCs-exosomes in regeneration medicine: Current evidence and future perspectives

    BENSHUAI YOU1, HUI QIAN1,2,*

    BIOCELL, Vol.46, No.6, pp. 1459-1463, 2022, DOI:10.32604/biocell.2022.018378 - 07 February 2022

    Abstract Exosomes, especially from mesenchymal stem cells, have attracted extensive attention in regeneration medicine. Mesenchymal stem cells derived exosomes (MSCs-exosomes) have shown anti-inflammatory, anti-oxidant, anti-apoptosis and tissue regeneration effects in a variety of tissue injury repair models. MSCs-exosomes hold many excellent properties such as low immunogenicity, biocompatibility, and targeting capability. With the in-depth study on the generation and function of exosomes, MSCs-exosomes are considered to be the bright stars in the field of regenerative medicine. However, there are still many obstacles to overcome in terms of exosomes isolation, clinical trials and safety evaluation. In this article, More >

  • Open Access

    RETRACTION

    Retraction: M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells

    TAILIN WU1,#; XIANG ZHOU2,#; CANHUA YE1; WENCAN LU1; HAITAO LIN1; YANZHE WEI1; ZEKAI KE1; ZHENGJI HUANG1; JIANZHOU LUO1; HUIREN TAO1; CHUNGUANG DUAN1,*

    BIOCELL, Vol.46, No.4, pp. 1123-1123, 2022, DOI:10.32604/biocell.2022.020679 - 15 November 2021

    Abstract This article has no abstract. More >

  • Open Access

    VIEWPOINT

    Controversies in therapeutic application of mesenchymal stem cell-derived secretome

    FERENC SIPOS*, GYÖRGYI MŰZES

    BIOCELL, Vol.46, No.4, pp. 903-906, 2022, DOI:10.32604/biocell.2022.018200 - 15 December 2021

    Abstract Though mesenchymal stem cells (MSCs) are considered as an important pillar of regenerative medicine, their regenerative potential has been shown to be limited in several pathological conditions. The adverse properties of MSC-based cell therapy have drawn attention to the therapeutic use of MSC-derived secretome. However, MSC-originated exosomes and microvesicles can also possess a significant impact on disease development, including cancer. By interchanging secretome, MSCs can interact with tumor cells and promote mutual exchange/induction of cellular markers. In addition, enzymes secreted into and activated within exosomes can result in the acquisition of new tumor cell properties. More >

  • Open Access

    REVIEW

    The effect of exosomes in transferring TET signaling alterations

    SERGIU PASCA1,*, ANCUTA JURJ2

    BIOCELL, Vol.46, No.3, pp. 579-581, 2022, DOI:10.32604/biocell.2022.017926 - 18 November 2021

    Abstract Ten eleven translocation (TET) enzymes are composed of three representatives: TET1/2/3 which are involved in the hydroxymethylation of methylated cytosines. Because of the wide array of processes that are governed by these epigenetic marks, there have been a wide range of clinical effects associated with TET alterations. Even though many research groups have focused on analyzing the effect of TET alterations within certain cells, few have taken into consideration the effect of TET in the context of intercellular communication. One important entity through which intercellular communication occurs is represented by exosomes. Thus, in the current More >

  • Open Access

    ARTICLE

    A549/DDP derived exosomes can affect cisplatin chemosensitivity via transporting CXCR4 to A549 cells

    MINGMING FANG1,#, NING GE2,#, JIANFANG LIU3,*, YAYUN CUI2,*

    BIOCELL, Vol.46, No.3, pp. 711-720, 2022, DOI:10.32604/biocell.2022.016714 - 18 November 2021

    Abstract The resistance of cancer cells to the anti-cancer drugs is the most important reason that affecting the efficacy of the non-small cell lung cancer (NSCLC) chemotherapy; thus, to explore the underlying mechanism of drug resistance of NSCLC medications is urgently needed for improving the therapeutic efficacy of current anti-NSCLC chemotherapies. The aim of the present study is to explore the roles of exosomes in the chemosensitivity of A549 cells and the related mechanism. A549 cells and cisplatin resistant cell line A549/DDP derived exosomes were isolated, and the expressions of CXCR4 were compared. Then, after cisplatin… More >

  • Open Access

    ARTICLE

    M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells

    TAILIN WU1,#, XIANG ZHOU2,#, CANHUA YE1, WENCAN LU1, HAITAO LIN1, YANZHE WEI1, ZEKAI KE1, ZHENGJI HUANG1, JIANZHOU LUO1, HUIREN TAO1, CHUNGUANG DUAN1,*

    BIOCELL, Vol.46, No.2, pp. 495-503, 2022, DOI:10.32604/biocell.2022.015214 - 20 October 2021

    Abstract Differentiated macrophages have been proven to participate in the development of mesenchymal stem cells in different tissues. However, the regulatory processes remain obscure. Exosomes, which are key secretions of macrophages, have attracted increasing attention. Therefore, macrophage-derived exosomes may modulate the development of Bone marrow mesenchymal stem cells (BMMSCs). Different culture conditions were used to induce M1 polarization in THP1 cells. Subsequently, exosomes derived from unpolarized (M0) and polarized (M1) macrophages were isolated, BMMSCs were cultured with normal complete medium or inductive medium supplemented with M0 or M1 derived exosomes, and the osteogenic capacity of the… More >

  • Open Access

    ARTICLE

    Lysophosphatidylcholine acyltransferase 1 is involved in the regulation of exosome secretion and uptake in colorectal cancer cells

    HAIZHENG LIU1, SHAOFEI CHANG2,*

    BIOCELL, Vol.46, No.2, pp. 453-462, 2022, DOI:10.32604/biocell.2021.015340 - 20 October 2021

    Abstract Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a phospholipid acyltransferase that promotes phospholipid synthesis and plasma membrane reconstruction. Exosomes play an important role in tumor metastasis. The release and uptake of exosomes are key steps of their functions and depend on plasma membrane fusion and plasma membrane receptors, respectively. The purpose of this study was to explore whether LPCAT1-induced plasma membrane remodeling would change the secretion and uptake behavior of exosomes in tumor cells. We first confirmed the abnormally high expression of LPCAT1 in colorectal cancer cells by quantitative real-time PCR (qPCR) and Western blot analysis. Then,… More >

  • Open Access

    REVIEW

    Mesenchymal stem cell-derived exosome as a nano weapon to target the COVID-19 pandemic

    YASHVI SHARMA, SUCHI GUPTA, SUJATA MOHANTY*

    BIOCELL, Vol.45, No.3, pp. 517-520, 2021, DOI:10.32604/biocell.2021.014621 - 03 March 2021

    Abstract In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will More >

  • Open Access

    ARTICLE

    Exosomes derived from osteoclasts under compression stress inhibit osteoblast differentiation

    YUE WANG, YUNFEI ZHENG*, WEIRAN LI*

    BIOCELL, Vol.45, No.2, pp. 427-444, 2021, DOI:10.32604/biocell.2021.013960 - 19 February 2021

    Abstract Orthodontic tooth movement is triggered by orthodontic force loading on the periodontal ligament and is achieved by alveolar bone remodeling, which is regulated by intimate crosstalk between osteoclastogenesis and osteoblast differentiation. Whether the communication between osteoclasts and osteoblasts is influenced by orthodontic compression stress requires further clarification. In this study, osteoclasts were differentiated for 10 days. On day 4 of differentiation, the number of pre-osteoclasts peaked, as determined by the increased expression of RANK and the number of multinucleated cells. After 24 h of compression stress loading, on day 4, the number of osteoclasts increased,… More >

Displaying 21-30 on page 3 of 33. Per Page