CUIXIA CHEN^1*, LINGLING CUI², XIN SHANG², XIANLU ZENG²

BIOCELL, Vol.34, No.2, pp. 57-64, 2010, DOI:10.32604/biocell.2010.34.057

Abstract L-selectin is a member of the selectin family that play an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells. Furthermore, L-selectin can function as a signal molecule. In our previous studies, we reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce CSF-1 gene transcription greatly in the activated Jurkat cells. Furthermore, we found that NFAT can be recruited… More >

SILVIA S. BORKOSKY^1,2, HITOSHI NAGATSUKA¹, YORIHISA ORITA³, HIDETSUGU TSUJIGIWA⁴, JUNKO YOSHINOBU³, MEHMET GUNDUZ¹, ANDREA P. RODRIGUEZ¹, LILIANA R. MISSANA², KAZUNORI NISHIZAKI³, NORIYUKI NAGAI¹

BIOCELL, Vol.32, No.3, pp. 251-257, 2008, DOI:10.32604/biocell.2008.32.251

Abstract The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. Math1 encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during… More >

Borghi ML¹, MA Ibañez¹, NC Bonamico¹, MV Kandus², D Almorza Gomar³, EA Guillin², JC Salerno², MA Di Renzo¹

Phyton-International Journal of Experimental Botany, Vol.81, pp. 123-131, 2012, DOI:10.32604/phyton.2012.81.123

Abstract Mal de Río Cuarto (MRC) disease is a significant threat to corn production in Argentina. Sixty six hybrid combinations derived from the cross of twelve flint maize (Zea mays L) inbred lines were evaluated using a completely randomized block design with two replications. MRC disease severity grade (SG) and grain yield (GY) were the analyzed traits. Our objectives were to estimate the general (GCA) and specific (SCA) combining abilities for these traits among twelve corn inbred lines, and to identify potential heterotic relationships among them. Diallel crosses were performed and these results were compared using Griffing’s method 2 model I… More >

Gonzalez-Franco AC¹, L Robles-Hernandez¹, A Nuñez-Barrios¹, JL Strap², DL Crawford³

Phyton-International Journal of Experimental Botany, Vol.78, pp. 83-90, 2009, DOI:10.32604/phyton.2009.78.083

Abstract In order to understand the temporal dynamics of actinomycete communities of the rhizosphere of the desert plant Artemisia tridentata (sagebrush), two complementary methods were used. They were: (1) 16S rDNA-based PCR coupled with denaturing gradient gel electrophoresis (DGGE), and (2) an agar plate enumeration methodology in which three different media were used to quantify total bacteria, actinomycetes, and fungi. The objective of this research were: (1) to obtain a comprehensive picture of the structure of actinomycete populations, and (2) their dynamics in the rhizosphere of young and old sagebrush plants during two distinct seasons. PCR-DGGE analysis showed that actinomycete groups… More >

Zhiqiang Ma^1,2, Lingshuang Kong^1,2, Xianlong Jin^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.1, pp. 51-67, 2018, DOI:10.31614/cmes.2018.01739

Abstract Many engineering applications need to analyse the system dynamics on the macro and micro level, which results in a larger computational effort. An explicit-implicit asynchronous step algorithm is introduced to solve the structural dynamics in multi-scale both the space domain and time domain. The discrete FEA model is partitioned into explicit and implicit parts using the nodal partition method. Multiple boundary node method is adopted to handle the interface coupled problem. In coupled region, the implicit Newmark coupled with an explicit predictor corrector Newmark whose predictive wave propagates into the implicit mesh. During the explicit subcycling process, the variables of… More >

C. Shu^1,2, H. Ding², K.S. Yeo²

CMES-Computer Modeling in Engineering & Sciences, Vol.7, No.2, pp. 195-206, 2005, DOI:10.3970/cmes.2005.007.195

Abstract Local radial basis function-based differential quadrature (RBF-DQ) method was recently proposed by us. The method is a natural mesh-free approach. It can be regarded as a combination of the conventional differential quadrature (DQ) method with the radial basis functions (RBFs) by means of taking the RBFs as the trial functions in the DQ scheme. With the computed weighting coefficients, the method works in a very similar fashion as conventional finite difference schemes. In this paper, we mainly concentrate on the applications of the method to incompressible flows in the steady and unsteady regions. The multiquadric (MQ) radial basis functions are… More >

Daisuke Ishihara^1,2, Tomoyoshi Horie¹, Tomoya Niho¹, Akiyoshi Baba³

CMES-Computer Modeling in Engineering & Sciences, Vol.108, No.6, pp. 429-452, 2015, DOI:10.3970/cmes.2015.108.429

Abstract In this study, a hierarchal decomposition is proposed to solve the structure- fluid-electrostatic interaction in a microelectromechanical system (MEMS). In the proposed decomposition, the structure-fluid-electrostatic interaction is partitioned into the structure-fluid interaction and the electrostatic field using the iteratively staggered method, and the structure-fluid interaction is split into the structurefluid velocity field and the fluid pressure field using the projection method. The proposed decomposition is applied to a micro cantilever beam actuated by the electrostatic force in air. It follows from the comparisons among the numerical and experimental results that the proposed method can predict the MEMS vibration characteristics accurately. More >

Sudib K. Mishra¹, J. K. Paik², S. N. Atluri¹

CMES-Computer Modeling in Engineering & Sciences, Vol.50, No.1, pp. 67-96, 2009, DOI:10.3970/cmes.2009.050.067

Abstract We present a simulation based study, by combining several models involving multiple time scales and physical processes, which govern the interfacial stress corrosion cracking (SCC) in grain boundaries, layered composites or bi-materials, and the mechanisms of inhibition using `smart' agents. The inhibiting agents described herein, automatically sense the initiation of damage, migrate to the sites and delay the corrosion kinetics involved in the process. The phenomenon of SCC is simulated using the lattice spring model (for the mechanical stresses), coupled with a finite difference model of diffusing species, causing the dissolution of the interfacial bonds. The dissolution is expressed through… More >

A.J. Yiotis¹, J.T. Katsikadelis¹

CMES-Computer Modeling in Engineering & Sciences, Vol.1, No.2, pp. 95-104, 2000, DOI:10.3970/cmes.2000.001.255

Abstract The Analog Equation Method is applied to the static and dynamic analysis of thin cylindrical shell panels. The Fl\"{u}gge theory is adopted. The three displacement components are established by solving two membrane and one plate bending problems under the same boundary conditions subjected to "appropriate'' (equivalent) fictitious loads. Numerical results are presented which illustrate the efficiency and the accuracy of the proposed method. More >