Tao Wang, Fan Shi, JiQuan Wang, Zi Liu, Jin Su

Oncology Research, Vol.28, No.9, pp. 969-970, 2020, DOI:10.3727/096504022X16414984936773

Abstract Kallistatin has been recognized as an endogenous angiogenesis inhibitor and exerts pleiotropic effects in inhibiting tumor growth, migration, apoptosis, and inflammation. The purpose of the present study was to investigate the potential role and mechanisms of kallistatin in cervical cancer. We demonstrated that kallistatin effectively inhibited cell proliferation and enhanced apoptosis in a dose-dependent manner. Additionally, kallistatin suppressed migration and invasion activities and markedly reduced the expression of matrix-degrading metalloproteinases, progelatinase (MMP-2), MMP-9, and urokinase-type PA (uPA). Kallistatin reversed the epithelial–mesenchymal transition (EMT) and caused the upregulation of epithelial markers such as E-cadherin and inhibited mesenchymal markers such as N-cadherin… More >

Hui Li^*1, Han-Han Li^†1, Qian Chen^‡1, Yu-Yang Wang^‡, Chang-Chang Fan^‡, Yuan-Yuan Duan^‡, You Huang^‡, Hui-Min Zhang^‡, Jia-Peng Li^‡, Xiao-Yu Zhang^‡, Yuan Xiang^‡, Chao-Jiang Gu^‡, Li Wang^§, Xing-Hua Liao^‡, Tong-Cun Zhang^‡¶

Oncology Research, Vol.28, No.9, pp. 885-897, 2020, DOI:10.3727/096504021X16274672547967

Abstract Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in breast cancer. The role of MKL-1’s regulation of DNMT1 in breast cancer cell proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been proved that DNMT1 is the… More >

Lili Lv^*, Xiaodong Wang^†

Oncology Research, Vol.28, No.7-8, pp. 835-835, 2020

Abstract This article has no abstract. More >

Yanli Wang^*, Jia Li^†, Chunling Xu^†, Xiaomeng Zhang^†

Oncology Research, Vol.28, No.7-8, pp. 823-825, 2020, DOI:10.3727/096504021X16240202940021

Abstract Increasing evidence indicates that the dysregulation of microRNAs is associated with the development and progression of various cancers. MicroRNA-139-5p (miR-139-5p) has been reported to have a tumor suppressive role in many types of cancers. The role of miR-139-5p in ovarian cancer (OC) is poorly understood. The purpose of the present study was to explore the expression of miR-139-5p and its function in OC. The results showed that miR-139-5p expression was markedly downregulated in OC tissues and cell lines. In addition, underexpression of miR-139-5p was significantly associated with FIGO stage, lymph mode metastasis, and poor overall survival of OC patients. Functional… More >

Huiling Wang^*, Xin Hu^†, Feng Yang^‡, Hui Xiao^*

Oncology Research, Vol.28, No.7-8, pp. 731-744, 2020, DOI:10.3727/096504020X16100888208039

Abstract This study was designed to investigate the precise mechanisms of miR-325-3p/S100A2 axis in breast cancer (BC). In this study, we found that the level of miR-325-3p was dramatically increased in BC tissues and cell lines, and the expression of S100A2 was significantly decreased. Also, the high level of miR-325-3p was closely associated with low expression of S100A2 in BC tissues. Moreover, introduction of miR-325-3p significantly promoted proliferation, invasion, and EMT of BC cells. Bioinformatics analysis predicted that the S100A2 was a potential target gene of miR-325-3p. Luciferase reporter assay demonstrated that miR-325-3p could directly target S100A2. In addition, miR-325-3p overexpression… More >

Zhong-xin Zhou^*, Zu-ping Zhang^†, Ze-zhang Tao^*, Ting-zhao Tan^‡

Oncology Research, Vol.28, No.1, pp. 21-31, 2020, DOI:10.3727/096504018X15213142076069

Abstract Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and implicated in human malignancies; however, its biological role in laryngeal carcinoma remains to be elucidated. The present study aimed at exploring the role of miR-632 in laryngeal cancer and clarifying the potential molecular mechanisms involved. In the current study, miR-632 was found to be significantly upregulated both in laryngeal cancer tissues and laryngeal cancer… More >

Adilijiang Maimaitiming^*, Ailijiang Wusiman^†, Abulajiang Aimudula^†, Xuekelaiti Kuerban^*, Pengcheng Su^*

Oncology Research, Vol.28, No.1, pp. 13-19, 2020, DOI:10.3727/096504019X15519249902838

Abstract The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target gene of miR-152 in… More >

Yuqin Xie, Shuang Deng, Qian Deng, Jiudong Xu

Oncologie, Vol.23, No.4, pp. 609-609, 2021, DOI:10.32604/oncologie.2021.020379

Abstract This article has no abstract. More >

Ping Zhao^1,#, Yao Xu^1,#, Anqi Wu², Yuhao Hu², Aiting Cai², Xinyue Wang³, Feng Wang^2,*, Xiang Chen^1,*

Oncologie, Vol.23, No.4, pp. 589-601, 2021, DOI:10.32604/oncologie.2021.018713

Abstract Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in HCC. Cell experiments… More >

RUONAN GU^1,2, WENJING GUO², WENYANG WANG¹, GUIHUAN LI¹, XIAOJU LAI¹, ZHIBIN HUANG¹, WANLU ZHAO¹, ZHICONG WU¹, HUA CHEN¹, WENYANG LUO¹, FANGYIN ZENG^3,*, FAN DENG^1,*

BIOCELL, Vol.45, No.6, pp. 1585-1599, 2021, DOI:10.32604/biocell.2021.017016

Abstract Propofol, a common intravenous anesthetic used in clinical, has been shown to regulate cells proliferation, inflammation, angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer. However, the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown. The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer (CRC). Scratches assay, Transwell assay were used to detect colon cells migration and invasion. Real-time Quantitative Polymerase Chain Reaction (RT-qPCR), Western blotting were utilized to detect the expression of related molecules.… More >