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  • Open Access

    REVIEW

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

    KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*

    Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

    Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

  • Open Access

    ARTICLE

    Mechanical and Biological Properties of Chitosan Nanocomposite Films: Effects of POSS nanoparticles

    R. VENKATESAN*, S. R. DARSON IMMANUEL JOHN, N. RAJESWARI

    Journal of Polymer Materials, Vol.36, No.3, pp. 261-273, 2019, DOI:10.32381/JPM.2019.36.03.6

    Abstract Nanocomposite films of chitosan (CH) incorporated with different wt. % of the polyoligomericsilsesquioxane (POSS) were prepared by solution casting. The thermal, mechanical, morphological and antimicrobial properties of the nanocomposites were examined. TGA analyses of the nanocomposites indicate that the filler enables the enhancement of thermal stability of chitosan. The tensile strength of the nanocomposite films is enhanced (10.9 MPa for neat chitosan to 24.0MPa for 5wt. % filled chitosan) by the addition of POSS while the elongation at break is reduced. The nanocomposite films exhibited excellent antimicrobial activity against both gram positive and gram negative bacteria. This activity increases with… More >

  • Open Access

    ARTICLE

    Chitosan/PVA Films and Silver Nanoparticle Impregnated Nanofibrous Dressings for Evaluation of their Wound Healing Efficacy in Wistar Albino Rat Model

    SOBHA KOTA*, RATNAKUMARI ANANTHA, VAYUNANDANA RAO GOVADA, PRADEEP DUMPALA

    Journal of Polymer Materials, Vol.40, No.3-4, pp. 285-303, 2023, DOI:10.32381/JPM.2023.40.3-4.10

    Abstract The exoskeleton of marine shrimp contains a natural, biocompatible polymer chitin, which is dumped as a waste. The study proposes the sustainable single-pot-extraction of chitosan from the waste and its use in the fabrication of wound-dressings, and thus leverage its piezoelectric, antioxidant, hypoglycaemic and medicinal properties in wound-healing. The Fourier transform infrared spectrum revealed that marine chitosan contains functional groups with N-O, O-H, and CO stretching. Scanning electron micrographs demonstrated the spherical and mesoporous structures of the extracted chitosan. X-ray diffraction analysis showed a semi-crystalline phase of chitosan particles with a mean size of 28.9 nm. The film prepared with… More >

  • Open Access

    ARTICLE

    THERMAL PERFORMANCE ENHANCEMENT OF PARAFFIN WAX WITH AL2O3 AND CuO NANOPARTICLES – A NUMERICAL STUDY

    A. Valan Arasua,*, Agus P. Sasmitob,†, Arun S. Mujumdarb

    Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-7, 2011, DOI:10.5098/hmt.v2.4.3005

    Abstract The heat transfer enhancement of paraffin wax, a cheap and widely used latent heat thermal energy storage material, using nanoparticles is investigated. The effects of nanoparticle volume fraction on both the melting and solidification rates of paraffin wax are analysed and compared for Al2O3 and CuO nanoparticles. Present results show that dispersing nanoparticles in smaller volumetric fractions increase the heat transfer rate. The enhancement in thermal performance of paraffin wax is greater for Al2O3 compared with that for CuO nanoparticles. More >

  • Open Access

    ARTICLE

    HEAT TRANSFER MEASUREMENTS FOR FLOW OF NANOFLUIDS IN MICROCHANNELS USING TEMPERATURE NANO-SENSORS

    Jiwon Yua , Seok-Won Kanga, Saeil Jeonb, Debjyoti Banerjeea,*

    Frontiers in Heat and Mass Transfer, Vol.3, No.1, pp. 1-9, 2012, DOI:10.5098/hmt.v3.1.3004

    Abstract Experiments were performed to study the forced convective heat transfer of de-ionized water (DI water) and aqueous nanofluids in a microchannel and temperature measurements were obtained using an array of nanosensors (i.e., thin film thermocouples or “TFT”). Heat flux values were calculated from the experimental measurements for temperature recorded by the TFT array. The experiments were performed for the different test fluids where the flow rate, mass concentration (of silica nanoparticles ~10-30 nm diameter) in the colloidal suspension and the wall temperature profile (as well as applied heat flux values) were varied parametrically.
    Anomalous enhancement of the convective heat… More >

  • Open Access

    ARTICLE

    The Influence of Tartaric Acid in the Silver Nanoparticle Synthesis Using Response Surface Methodology

    Yatim Lailun Ni’mah1, Afaf Baktir2, Dewi Santosaningsih3, Suprapto Suprapto1,*

    Journal of Renewable Materials, Vol.12, No.2, pp. 245-258, 2024, DOI:10.32604/jrm.2023.045514

    Abstract Silver nanoparticles (AgNPs) synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs. The protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity problems. These attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery applications. The aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration, sonication time and temperature on the formation of silver nanoparticles. Using Response Surface… More > Graphic Abstract

    The Influence of Tartaric Acid in the Silver Nanoparticle Synthesis Using Response Surface Methodology

  • Open Access

    ARTICLE

    Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

    Thean Heng Tan1, Najihah Mohd Hashim2, Wageeh Abdulhadi Yehya Dabdawb1, Mochamad Zakki Fahmi3,*, Hwei Voon Lee1,*

    Journal of Renewable Materials, Vol.12, No.1, pp. 29-43, 2024, DOI:10.32604/jrm.2023.043449

    Abstract The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose (NCC) as a potential drug delivery system for targeting folate receptor-positive cancer cells. The FA-functionalized NCCs were synthesized through a series of chemical reactions, resulting in nanoparticles with favorable properties for biomedical applications. The microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor tissues. Importantly, these nanoparticles possessed a negative surface charge, enhancing their stability and repelling potential aggregation. The binding specificity of FA-functionalized NCCs to folate… More > Graphic Abstract

    Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

  • Open Access

    ARTICLE

    Influence of Brownian Motion, Thermophoresis and Magnetic Effects on a Fluid Containing Nanoparticles Flowing over a Stretchable Cylinder

    Aaqib Majeed1,*, Ahmad Zeeshan2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.3, pp. 525-536, 2024, DOI:10.32604/fdmp.2023.028716

    Abstract The influence of Brownian motion and thermophoresis on a fluid containing nanoparticles flowing over a stretchable cylinder is examined. The classical Navier-Stokes equations are considered in a porous frame. In addition, the Lorentz force is taken into account. The controlling coupled nonlinear partial differential equations are transformed into a system of first order ordinary differential equations by means of a similarity transformation. The resulting system of equations is solved by employing a shooting approach properly implemented in MATLAB. The evolution of the boundary layer and the growing velocity is shown graphically together with the related profiles of concentration and temperature.… More >

  • Open Access

    ARTICLE

    Impact Analysis of Microscopic Defect Types on the Macroscopic Crack Propagation in Sintered Silver Nanoparticles

    Zhongqing Zhang1, Bo Wan1,*, Guicui Fu1, Yutai Su2,*, Zhaoxi Wu3, Xiangfen Wang1, Xu Long2

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 441-458, 2024, DOI:10.32604/cmes.2023.043616

    Abstract Sintered silver nanoparticles (AgNPs) are widely used in high-power electronics due to their exceptional properties. However, the material reliability is significantly affected by various microscopic defects. In this work, the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified, categorized, and quantified. Molecular dynamics (MD) simulations are employed to observe the failure evolution of different microscopic defects. The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion. At the same time, this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by… More >

  • Open Access

    ARTICLE

    Heat Transfer Characteristics for Solar Energy Aspect on the Flow of Tangent Hyperbolic Hybrid Nanofluid over a Sensor Wedge and Stagnation Point Surface

    Asmaa Habib Alanzi, N. Ameer Ahammad*

    Frontiers in Heat and Mass Transfer, Vol.21, pp. 179-197, 2023, DOI:10.32604/fhmt.2023.042009

    Abstract The conversion of solar radiation to thermal energy has recently attracted a lot of interest as the requirement for renewable heat and power grows. Due to their enhanced ability to promote heat transmission, nanofluids can significantly contribute to enhancing the efficiency of solar-thermal systems. This article focus solar energy aspect on the effects of the thermal radiation in the flow of a hyperbolic tangent nanofluid containing magnesium oxide (MgO) and silver (Ag) are the nanoparticle with the base fluid as kerosene through a wedge and stagnation. The system of hybrid nanofluid transport equations are transformed into ordinary differential systems using… More >

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