Gabrielle Yankelevich^1,*, Jessica Swaim¹, Ian Coate¹, Margaret Stroud¹, William Stallings¹, Virgilio George², M. Lance Tavana³, Harry Clarke¹

Canadian Journal of Urology, Vol.32, No.1, pp. 37-42, 2025, DOI:10.32604/cju.2025.064684 - 20 March 2025

Abstract Objectives: To assess outcomes of rectourethral fistula repair utilizing a gracilis flap in a largely radiated cohort. Patients and Methods: We performed a retrospective review of all gracilis interposition flap reconstruction surgeries performed for RUF at a university hospital in South Carolina between January 2010 and June 2023. All repairs utilized a multidisciplinary approach with urology, colorectal, and plastic surgery teams. Post-operatively, patients were maximally drained with foley catheter and suprapubic tube (SPT). Initial voiding cystourethrogram (VCUG) was performed at 4 weeks post-repair. If there was a persistent leak, catheter drainage was maintained for 4 additional… More >

MICHELE MAFFEZZOLI^1,2,#, GIULIA CLAIRE GIUDICE^1,2,#,*, GIACOMO IOVANE^1,2, MARTINA MANINI^1,2, ELENA RAPACCHI¹, GIUSEPPE CARUSO¹, NICOLA SIMONI³, STEFANIA FERRETTI⁴, STEFANO PULIATTI⁴, DAVIDE CAMPOBASSO⁵, SEBASTIANO BUTI^1,2

Oncology Research, Vol.33, No.4, pp. 741-757, 2025, DOI:10.32604/or.2024.057278 - 19 March 2025

Abstract Background: immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic urothelial carcinoma (mUC), significantly improving survival outcomes. However, a subset of patients do not respond to ICIs, prompting research into potential predictive factors. Commonly prescribed medications such as corticosteroids, proton-pump inhibitors (PPIs), antibiotics (Abs), antihypertensives, and analgesics may influence ICI effectiveness. Methods: we conducted a literature search on PubMed to investigate the impact of concomitant medications on the outcomes of patients with mUC, treated with ICIs. We selected the most relevant studies and performed a narrative review. Results: corticosteroids, PPIs and Abs have been associated More >

Yong An^1,2, Gang Wang^1,2, Jiangtao Dai^1,2, Zhengxia Pan^1,2, Yuhao Wu^1,2,*

Congenital Heart Disease, Vol.20, No.1, pp. 1-12, 2025, DOI:10.32604/chd.2025.063152 - 18 March 2025

Abstract Background Pulmonary arterial hypertension (PAH) is a progressive condition with a poor prognosis in children. Lung transplantation (Ltx) remains the ultimate option when patients are refractory to PAH-specific therapy. Reverse Potts shunt (RPS) has been introduced to treat suprasystemic PAH. This study aims to investigate the clinical outcomes of suprasystemic PAH in children. Methods Embase, Pubmed, and the Cochrane Library databases were searched for related studies that reported the clinical outcomes of suprasystemic PAH following RPS in children. To investigate the clinical outcomes of RPS, meta-analyses of the early and overall mortalities were performed. Results Nine studies… More >

Prathap Sarma¹, Palesa Mogane^2,*, Katharina Vanderdonck³, Moses Kebalepile¹, Palesa Motshabi Chakane⁴

Congenital Heart Disease, Vol.20, No.1, pp. 41-53, 2025, DOI:10.32604/chd.2025.060382 - 18 March 2025

Abstract Background: Congenital cardiac diseases (CCD) are common congenital birth defects that require high-risk surgery. Outcomes following congenital cardiac surgery in children living in high-income countries (HIC) have been documented, but little is known from the African continent. This study aimed to determine factors associated with perioperative mortality in patients who underwent congenital cardiac surgery at our institution. Methods: This retrospective, cross-sectional study was conducted at Charlotte Maxeke Johannesburg Academic Hospital over 12 years (2006–2017). A multivariable regression analysis was performed for the factors which had a p-value of 0.1 and less in the univariable regression analysis. A… More >

Ye Hoon Lee¹, Juhee Hwang^2,*

International Journal of Mental Health Promotion, Vol.27, No.2, pp. 179-191, 2025, DOI:10.32604/ijmhp.2025.060685 - 03 March 2025

Abstract Objectives: Recent research has shown that college students experience high levels of stress from various sources, which contribute to heightened rates of psychological distress and make them particularly vulnerable to mental health issues. Hence, we conducted a study, aimed to analyze the influence of a mobile-based walking routine on mental health outcomes, such as perceived stress and positive and negative affect. Methods: The participants were divided into two groups: the walking group (N = 23) and the control group (N = 24). The walking group engaged in an approximately 25-min walking session for at least 3 days… More >

Sha Chen^1,#, Minkai Cao^1,#, Kerong Liu^2,*, Ying Gu^1,*

BIOCELL, Vol.49, No.2, pp. 181-198, 2025, DOI:10.32604/biocell.2025.058745 - 28 February 2025

Abstract The increasing prevalence of gestational diabetes mellitus (GDM) is associated with an array of pregnancy complications and enduring health challenges in both mothers and their offspring. Studies have indicated that exposure to the intrauterine environment can prompt adaptations in the offspring, thereby programming transgenerational inheritance. Physical activity during pregnancy, as a non-pharmacological intervention, mitigates metabolic risks through epigenetic modifications, mediating placental adaptations, the action of exercise factors, and gut microbiota. Here, we provide a review summarizing how regular exercise can reduce the risk of GDM and positively influence pregnancy outcomes. It also discusses the exercise-induced More >

Cassra B. Clark, Jay D. Raman

Canadian Journal of Urology, Vol.31, No.1, pp. 11775-11776, 2024

Abstract This article has no abstract. More >

Alex J. Xu¹, Sameer Thakker², Vyom Sawhney², Rozalba Gogaj¹, Fjolla Vokshi¹, James S. Wysock¹

Canadian Journal of Urology, Vol.31, No.1, pp. 11767-11774, 2024

Abstract Introduction: We evaluate the rate of developing ciprofloxacin resistance in patients undergoing repeat prostate biopsies (PBx), associated risk factors, and impact on complications.
Materials and methods: We retrospectively evaluated pre-procedural rectal culture (RCx) data in men undergoing PBx from 1/1/2016 to 1/15/2021. Univariate and multivariate logistic regression were utilized to identify risk factors associated with development of antibiotic resistance. Complication rates were compared between ciprofloxacin-sensitive and ciprofloxacin resistant patients.
Results: A total of 743 men underwent initial RCx. Initial RCx detected ciprofloxacin resistance in 22% of patients. A history of diabetes (p = 0.01), > 2 prior prostate… More >

Rishabh K. Simhal^*, Kerith R. Wang^*, Caroline Purcell, Yash B. Shah, Paul H. Chung

Canadian Journal of Urology, Vol.31, No.2, pp. 11826-11833, 2024

Abstract Introduction: Gender affirming surgeries (GAS), such as phalloplasty (PLPs) and vaginoplasty (VGPs), are important aspects of medical care for transgender patients. Here, we aim to better characterize patient demographics and surgical outcomes for PLPs and VGPs using the National Surgical Quality Improvement Program (NSQIP). We hypothesized that frailty indices would be predictive of perioperative PLP and VGP risk and outcomes for PLPs and VGPs.
Materials and methods: Primary GAS, specifically PLPs and VGPs performed from 2006-2020 were identified in NSQIP. Baseline frailty was based on NSQIP’s modified frailty index (mFI) and preoperative morbidity probability (morbprob) variable.
Results: Fifty-eight… More >

E. David Crawford¹, David Albala², Marc B. Garnick³, Andrew W. Hahn⁴, Paul Maroni⁵, Rana R. McKay⁶, Martin Miner⁷, Peter Orio III⁸, Kshitij Pandit¹, Scott Sellinger⁹, Evan Y. Yu¹⁰, Robert H. Eckel¹¹

Canadian Journal of Urology, Vol.31, No.2, pp. 11820-11825, 2024

Abstract Introduction: Risk of cardiovascular disease is higher among men with prostate cancer than men without, and prostate cancer treatments (especially those that are hormonally based) are associated with increased cardiovascular risk.
Materials and methods: An 11-member panel of urologic, medical, and radiation oncologists (along with a men’s health specialist and an endocrinologist/ preventive cardiologist) met to discuss current practices and challenges in the management of cardiovascular risk in prostate cancer patients who are taking androgen deprivation therapies (ADT) including LHRH analogues, alone and in combination with androgen-targeted therapies (ATTs).
Results: The panel developed an assessment algorithm to categorize… More >