YU ZHANG^1,2, QINGKUN WANG², YUE HAN², JUNJIE PIAO^2,*, XIUYING JIN^1,2,*

Oncology Research, Vol.33, No.8, pp. 1933-1945, 2025, DOI:10.32604/or.2025.063395 - 18 July 2025

Abstract Background: Colorectal adenocarcinoma (COAD) is one of the most common gastrointestinal malignancies. There is a pressing need to recognize reliable biomarkers that can improve diagnostic accuracy, predict prognosis, and serve as effective molecular targets. Glutathione peroxidase 4 (GPX4) is an important antioxidant protein. Evidence demonstrates that abnormal expression of GPX4 is related to cancer initiation and progression. However, the role of GPX4 in COAD remains unclear. Methods: We employed bioinformatics analysis and conducted subsequent validation of biological processes, including cell counting kit-8 assay (CCK-8), colony formation assay, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), 5-ethynyl-2′-deoxyuridine assay… More >

JIAHENG WEI¹, LIANGMING ZHU^2,*

Oncology Research, Vol.33, No.4, pp. 863-872, 2025, DOI:10.32604/or.2024.054201 - 19 March 2025

Abstract Lung cancer is one of the main causes of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most prevalent histological subtype of lung cancer. Glutathione peroxidase 4 (GPX4) is a crucial antioxidant enzyme that plays a role in regulating ferroptosis. It is also involved in a wide variety of biological processes, such as tumor cell growth invasion, migration, and resistance to drugs. This study comprehensively examined the role of GPX4 in NSCLC and investigated the clinical feasibility of targeting GPX4 for NSCLC treatment. We discovered that GPX4 influences the progression of NSCLC More >

JIE DUAN, AIDONG GU^*, WEI CHEN, CHANGHAO CHEN, FANGNAN SONG, FAXI CHEN, FANGFANG JIANG, HUIWEN XING

BIOCELL, Vol.47, No.12, pp. 2609-2615, 2023, DOI:10.32604/biocell.2023.042472 - 27 December 2023

Abstract Objective: This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4) in primary hepatic carcinoma (PHC). Methods: The expression of NRF2 and GPX4 in peripheral blood of patients with PHC was determined to analyze the diagnostic value of the two combined for PHC. The prognostic significance of NRF2 and GPX4 was evaluated by 3-year follow-up. Human liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased, and the expression of NRF2 and GPX4 in the cells was determined. NRF2 and GPX4… More > Graphic Abstract

José Adrian Perez-Robles, Carlos Alberto Lecona-Guzmán^*, Víctor Manuel Ruíz-Valdiviezo, Joaquín Adolfo Montes-Molina^*

Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2503-2518, 2023, DOI:10.32604/phyton.2023.029784 - 28 July 2023

Abstract The objective to this work was to evaluate the enzymatic activity in the culture of Solanum lycopersicum L. infected with Fusarium oxysporum after the combined application of Beauveria bassiana and plant extracts. Solanum lycopersicum plantlets were transplanted 15 days after the emergency. Five days after transplanting, Beauveria bassiana spores were applied at a concentration of 1 × 10⁷ spores mL⁻¹ onto soil (along with A. indica (N) and P. auritum (H) leaf extracts) where S. lycopersicum plants were planted. Eight days after transplanting, spores of F. oxysporum strain were applied at a concentration of 1 × 10⁶ spores mL⁻¹ to soil where S. lycopersicum plants were growing.… More >

Dalila Jacqueline Escudero-Almanza¹, Oscar Cruz-Alvarez¹, Ofelia Adriana Hernández-Rodríguez¹, Juan Luis Jacobo-Cuellar¹, Esteban Sánchez-Chávez², Pablo Preciado-Rángel³, Dámaris Leopoldina Ojeda-Barrios^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.6, pp. 1141-1152, 2022, DOI:10.32604/phyton.2022.019129 - 14 February 2022

Abstract Pecan [Carya illinoinensis (Wangenh.) K. Koch.] is a deciduous tree whose fruits (nuts) are of high economic value and offer excellent nutritional benefits. However, soils high in sulphates can limit its growth and development. Working with 5-year-old trees of ‘Western Schley’ pecan grown in soils high in sulphates, the levels of proline and oxidative metabolism were recorded in the leaflets. Results showed that different levels of visible leaflet damage (‘sufficiency’, ‘low’, ‘moderate’ or ‘severe’) were associated with different levels of leaflet sulphates (mg kg⁻¹): ‘sufficiency’ (≤40), ‘low’ (41–60), ‘moderate’ (61–80) and ‘severe’ (80–100). ‘Severe’ sulphate damage was… More >

FRANCISCO J. CORPAS^*, SALVADOR GONZÁLEZ-GORDO, MARTA RODRÍGUEZ-RUIZ, MARÍA A. MUÑOZ-VARGAS, JOSÉ M. PALMA

BIOCELL, Vol.46, No.1, pp. 1-5, 2022, DOI:10.32604/biocell.2021.017300 - 29 September 2021

Abstract Nitric oxide (NO) and hydrogen sulfide (H₂S) are two molecules that share signaling properties in plant and animal cells. NO and H₂S originate two families of derived molecules designated reactive nitrogen and sulfur species (RNS and RSS, respectively). These molecules are responsible for certain protein regulatory processes through posttranslational modifications (PTMs), being the most remarkable S-nitrosation and persulfidation, which affect the thiol group of cysteine residues. NO and H₂S can also exert regulatory functions due to their interaction through the iron present in proteins that contain heme groups or iron-sulfur clusters, as reported mainly in animal cells. More >

Monika Sood¹, Shanti S. Sharma¹, Joginder Singh¹, Ram Prasad^2,3,*, Dhriti Kapoor^1,*

Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 71-86, 2020, DOI:10.32604/phyton.2020.07180 - 01 March 2020

Abstract The heavy metals present in the environment accumulate in the plants and affect their productivity and yield. By entering the food chain, metals cause several serious health problems in human beings as well as in other organisms. Indole acetic acid (IAA) is known to act as a signaling molecule between symbiotic association of metal accumulating plants and plant growth promoting rhizobacteria (PGPR). Present study demonstrated a protective role of IAA against surplus Zinc (Zn)-induced toxicity to Hordeum vulgare seedlings. Elevated Zn concentrations suppressed the plant growth, caused a reduction in leaf relative water contents (RWC) and More >

John M. Ferguson

Congenital Heart Disease, Vol.14, No.1, pp. 52-56, 2019, DOI:10.1111/chd.12715

Abstract Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause‐and‐effect has been proven for short‐term or long‐term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short‐term complications and long‐term adverse outcomes are worrisome. Intravenous indomethacin has been the “gold standard” for pharmacologic treatment over the past 40 years with high closure rates and decreased More >

Abud-Archila M¹, AK Espinosa-Arrioja¹, T González-Soto², VF Gutiérrez-Oliva¹, V Ruíz-Valdiviezo¹, D González-Mendoza², L Rodríguez-Hernández³, FA Gutiérrez-Miceli¹

Phyton-International Journal of Experimental Botany, Vol.87, pp. 209-215, 2018, DOI:10.32604/phyton.2018.87.209

Abstract The aim of this investigation was to analyze the effect of vermicompost and phosphate rock on plant growth and biochemical responses of Moringa oleifera exposed to water deficit and waterlogging conditions. Treatments included 152 g of vermicompost (V) and 1.3 g of phosphate rock (PR) added to each cultivation bag. Control was prepared with 2.3 g of urea. All treatments were irrigated under different watering conditions [water deficit: irrigated at 20% water holding capacity (WHC); control (40% WHC) and waterlogging (60% WHC)]. The overall average in plant height was 90, 86 and 68 cm, whereas chlorophyll… More >

Hernández LF^1,2, PM Bellés³, MA Bidegain^4,5, PD Postemsky⁴

Phyton-International Journal of Experimental Botany, Vol.87, pp. 198-208, 2018, DOI:10.32604/phyton.2018.87.198

Abstract Absence or underdevelopment of sunflower fruits come usually from failure in fertilization, stresses as well as physiological and morphological defects in the ovary. Thigmomorphogenesis has never been included as a possible cause. We have previously shown that a 2-3 day fertilization shift can occur between neighboring florets in the sunflower capitulum. It is proposed here that those ovaries with advanced fertilization can generate a significant radial and axial compressive stress on ovaries with delayed fertilization. This mechanical stimulus could be strong enough to trigger a thigmo response that affects further ovary development. In vivo tests… More >