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  • Open Access


    Construction of Customized Bio Incubator and Designing of Tailored Scaffolds for Bone Tissue Engineering from Laboratory Scale Up to Clinical Scale

    Soliman Abdalla1,2,*, Shiref Kandil2

    Journal of Renewable Materials, Vol.10, No.11, pp. 2699-2716, 2022, DOI:10.32604/jrm.2022.022334

    Abstract In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get better products. The present study… More >

  • Open Access


    A nanostructured look of collagen apatite porosity into human mineralized collagen fibril


    BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150

    Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization at nanoscale and on the… More >

  • Open Access


    Mesenchymal stem cells, secretome and biomaterials in in-vivo animal models: Regenerative medicine application in cutaneous wound healing


    BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448

    Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound healing. Studies demonstrate that there… More >

  • Open Access


    Tuning mesenchymal stem cell secretome therapeutic potential through mechanotransduction


    BIOCELL, Vol.46, No.6, pp. 1375-1381, 2022, DOI:10.32604/biocell.2022.019681

    Abstract Mesenchymal stem cells (MSCs) and their byproducts have been widely validated as potential therapeutic products for regenerative medicine. The therapeutic effects result mainly from the paracrine activity of MSCs, which consists of the secretion of bioactive molecules, whether dispersed in medium conditioned by cell culture or encapsulated in extracellular vesicles. The composition of the MSC secretome, which represents the set of these secreted cellular products, is crucial for the performance of the desired therapeutic functions. Different cell culture strategies have been employed to adjust the secretome composition of MSCs to obtain the best therapeutic responses for different clinical contexts. However,… More >

  • Open Access


    Applications of scaffolds: Tools for enhancing the immunomodulation of mesenchymal stromal cells


    BIOCELL, Vol.46, No.6, pp. 1439-1443, 2022, DOI:10.32604/biocell.2022.018921

    Abstract Exogenously delivered mesenchymal stromal cells (MSCs) are therapeutically beneficial owing to their paracrine effect; they secrete various cytokines, nucleic acids, and proteins. Multiple bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions (both structurally and functionally). Various scaffolds mimic the natural extracellular matrix (ECM) using both natural and synthetic polymers, providing favorable environments for MSC proliferation and differentiation. Depending on material properties, either topographically or elastically structured scaffolds can be fabricated. Three-dimensional scaffolds have tunable substrate rigidities and structures, aiding MSC cultivation. Decellularized ECM-derived hydrogels are similar to the natural ECM, thus improving the… More >

  • Open Access


    Optimal Bioprinting Parameters and Experimental Investigation of Acellular Dermal Matrix Scaffold

    Qingxi Hu1,2,3, Yiming Wang1, Dongchao Yang4, Haiguang Zhang1,2,3,*, Zhicheng Song4, Yan Gu4,*

    Journal of Renewable Materials, Vol.9, No.1, pp. 1-16, 2021, DOI:10.32604/jrm.2021.013319

    Abstract Acellular dermal matrix (ADM) as a biomaterial is currently believed to be promising tissue repair improvement. With the development of tissue engineering, ADM is increasingly used as biological scaffolds. We explored the feasibility and performance of ADM biological scaffolds that fabricated by 3D printing. This paper presented our study on the printability of 3D printed ADM scaffolds, with a focus on identifying the influence of printing parameters/conditions on printability. To characterize the printability, we examined the fiber morphology, pore size, strand diameter, and mechanical property of the printed scaffolds. Our results revealed that the printability could be affected by a… More >

  • Open Access


    Poly (vinyl alcohol)/Graphene Nanocomposite Hydrogel Scaffolds for Control of Cell Adhesion

    Xiaodong Wang1,2, Meng Su2, Chuntai Liu2, Changyu Shen2, Xianhu Liu2,*

    Journal of Renewable Materials, Vol.8, No.1, pp. 89-99, 2020, DOI:10.32604/jrm.2020.08493

    Abstract Poly (vinyl alcohol) (PVA)/reduced graphene oxide (rGO) nanocomposites is prepared by the immersion of PVA/graphene oxide (GO) nanocomposites in the reducing agent aqueous solution. The PVA/graphene nanocomposites can be used as scaffold after treatment by chemical crosslinking agents. The surface hydrophilicity of the nanocomposite scaffolds decreased with the addition of GO or rGO by measuring the contact angles of scaffolds. The electrical conductivity of PVA/rGO nanocomposite scaffold increased with rGO content increased. The highest conductivity of PVA/rGO nanocomposite scaffolds with 10 wt% rGO could reach to 12.16 × 10−3 S/m. The NIH-3T3 fibroblasts attach and grow well on the surface… More >

  • Open Access


    Hepatocyte culture in a radial-flow bioreactor with plasma polypyrrole coated scaffolds


    BIOCELL, Vol.39, No.2-3, pp. 9-14, 2015, DOI:10.32604/biocell.2015.39.009

    Abstract We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated scaffold. We designed a culture chamber where a radial flow of culture medium was continuously delivered through it. Once this system was established, flow was simulated using flow dynamics software based on numeric methods to solve Navier-Stockes flow equations. Perfusion within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor chamber. Afterwards, the bioreactor was built according to the simulated design and was tested with liver… More >

  • Open Access


    Fabrication of Porous Scaffolds for Bone Tissue Engineering Using a 3-D Robotic System: Comparison with Conventional Scaffolds Fabricated by Particulate Leaching

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 179-180, 2006, DOI:10.32604/mcb.2006.003.179

    Abstract This article has no abstract. More >

  • Open Access


    The Effect of Processing Temperature on Mechanical Properties of Novel Silk Fibroin and Chitosan Blend Scaffolds for Musculoskeletal Regeneration

    C. N. Rios1, J. N. Augustine1, A. B. Mathur1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 173-174, 2006, DOI:10.32604/mcb.2006.003.173

    Abstract This article has no abstract. More >

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