Yuan Ren¹, Yingxian Sun¹, Zhiguang Yang², Yanli Chen^1,*

Congenital Heart Disease, Vol.19, No.2, pp. 157-176, 2024, DOI:10.32604/chd.2024.047930 - 16 May 2024

Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a chronic, progressive, debilitating, and life-threatening complication of pulmonary embolism (PE). Recent technological advances have permitted various treatment options for the treatment of CTEPH, including surgery, angioplasty, and medical treatment, depending on the location and characteristics of lesions. Pulmonary endarterectomy (PEA) is the treatment of choice for CTEPH, as it offers excellent long-term outcomes and a high probability of recovery. Moreover, various medical and interventional therapies are currently being developed for patients with inoperable CTEPH. This review mainly summarizes the current treatment approaches of CTEPH, offering more options for More >

Chengbao Hu^1,2,3, Shilin Gong^4,*, Bin Chen^1,2,3, Zhongling Zong⁴, Xingwang Bao⁵, Xiaojian Ru⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 997-1015, 2024, DOI:10.32604/cmes.2024.048640 - 16 April 2024

Abstract Strain localization frequently occurs in cohesive materials with friction (e.g., composites, soils, rocks) and is widely recognized as a fundamental cause of progressive structural failure. Nonetheless, achieving high-fidelity simulation for this issue, particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones, remains significantly constrained. In response, this study introduces an integrated algorithm within the finite element framework, merging a coupled cohesive zone model (CZM) with the nonlinear augmented finite element method (N-AFEM). The coupled CZM comprehensively describes tension-compression and compression-shear failure behaviors in cohesive, frictional materials, while the N-AFEM allows nonlinear coupled intra-element discontinuities More >

Yujie Duan¹, Jianguo Liang^1,*, Jianglin Liu¹, Haifeng Gao¹, Yinhui Li², Jinzhu Zhang¹, Xinyu Wen³

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1239-1261, 2024, DOI:10.32604/cmes.2023.044400 - 29 January 2024

Abstract In the fiber winding process, strong disturbance, uncertainty, strong coupling, and fiber friction complicate the winding constant tension control. In order to effectively reduce the influence of these problems on the tension output, this paper proposed a tension fluctuation rejection strategy based on feedforward compensation. In addition to the bias harmonic curve of the unknown state, the tension fluctuation also contains the influence of bounded noise. A tension fluctuation observer (TFO) is designed to cancel the uncertain periodic signal, in which the frequency generator is used to estimate the critical parameter information. Then, the fluctuation More >

Xin Ai^1,2,*, Mian Chen¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.3, pp. 661-670, 2024, DOI:10.32604/fdmp.2023.026819 - 12 January 2024

Abstract

The efficient development and exploitation of shale oil depends on long-distance horizontal wells. As the degree of cleaning of the wellbore plays a key role in these processes, in this study, this problem is investigated experimentally by focusing on the dimensionless cuttings bed height. A method is proposed to calculate the horizontal-well hydraulic extension taking into account the influence of the wellbore cleaning degree on the wellbore pressure distribution and assess the effect of a variety of factors such as the bottom hole pressure, the circulating pressure drop, the drilling pump performance and the formation

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Dian Kesumarini^1,2, Yunita Widyastuti³, Cindy Elfira Boom¹, Lucia Kris Dinarti^4,*

Congenital Heart Disease, Vol.18, No.6, pp. 671-678, 2023, DOI:10.32604/chd.2023.044746 - 19 January 2024

Abstract Tetralogy of Fallot (TOF) with total anomalous pulmonary vein connections (TAPVC) is a rare type of complex congenital heart disease among all TOF cases. Co-presentation of major aortopulmonary collateral arteries (MAPCAs) compensates for the lack of central pulmonary blood flow and decreases the severity of right-to-left shunting in TOF. We present a case of a 2-year-old child with complex diagnoses of TOF, TAPVC, a large secundum atrial septal defect (ASD), and intraoperatively identified MAPCAs. She underwent surgery to repair the TAPVC, valve-sparing reconstruction of the right ventricular outflow tract, interventricular defect closure, and the creation… More >

IVANA PAJIC-LIJAKOVIC^*, MILAN MILIVOJEVIC

BIOCELL, Vol.47, No.11, pp. 2321-2334, 2023, DOI:10.32604/biocell.2023.043796 - 27 November 2023

Abstract The biointerface dynamics influence any cancer spreading through the epithelium since it is documented in the early stages some malignancies (like epithelial cancer). The altered rearrangement of epithelial cells has an impact on the development of cancer. Therefore, it is necessary to comprehend the underlying biological and physical mechanisms of this biointerface dynamics for early suppression of cancer. While the biological mechanisms include cell signaling and gene expression, the physical mechanisms are several physical parameters such as the epithelial-cancer interfacial tension, epithelial surface tension, and compressive stress accumulated within the epithelium. Although the segregation of… More > Graphic Abstract

CHENYANG CHEN^1,*, JUAN WEN¹, WEI HUANG¹, JIANG LI^2,*

BIOCELL, Vol.47, No.11, pp. 2423-2433, 2023, DOI:10.32604/biocell.2023.044459 - 27 November 2023

Abstract Background: Pulmonary arterial hypertension (PAH) is a chronic and progressive disease that is strongly associated with dysregulation of glucose metabolism. Alterations in nuclear receptor subfamily 4 group A member 1 (NR4A1) activity alter the outcome of PAH. This study aimed to investigate the effects of NR4A1 on glycolysis in PAH and its underlying mechanisms. Methods: This study included twenty healthy volunteers and twenty-three PAH patients, and plasma samples were collected from the participants. To mimic the conditions of PAH in vitro, a hypoxia-induced model of pulmonary artery smooth muscle cell (PASMC) model was established. The proliferation… More > Graphic Abstract

Liang Zhang^1,*, Zigang He¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09713

Abstract The different elastic properties of tension and compression are obvious in many engineering materials, especially new materials. Materials with this characteristic, such as graphite, ceramics, and composite materials, are called bi-modulus materials. Their mechanical properties such as Young’s modulus have randomness in tension and compression due to different porosity, microstructure, etc. To calibrate the mechanical properties of bi-modulus materials by bridging FEM simulation results and scarce experimental data, the paper presents a data-fusion computational method. The FEM simulation is implemented based on Parametric Variational Principle (PVP), while the experimental result is obtained by Digital Image… More >

Mengnan Zhang^1,*, Fucheng Tian¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09593

Abstract Peridynamic is a nonlocal theory that uses integral forms of governing equations, making it suitable for describing objects with discontinuous states such as cracks. After more than two decades of development, peridynamic has been effectively applied to numerous solid mechanics studies. However, in the field of ordinary state-based peridynamic modeling nonlinear deformation, a more comprehensive model that can establish a general connection with continuum mechanics and allow for the selection of different influence functions is still lacking. As a consequence, a further extension to existing models is promising, and it represents a substantial addition to… More >

Taotao Yuan¹, Haitian Yang¹, Yiqian He^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09275

Abstract Computational modeling can provide insight into understanding the damage mechanisms of soft biological tissues, and identification of constitutive parameters is key issues in the computational modeling. On the other hand, although it is thought that computational model should be non-local for soft tissues based on the existence of intrinsic length scales, there is very few work for the identification of the parameters of nonlocal damage models of soft tissues. Firstly, we use the gradient-enhanced damage model presented in our previous publication showing advantages in considering the internal length scales and in satisfying mesh independence for More >