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  • Open Access

    ARTICLE

    NOTCH3 Mutations and CADASIL Phenotype in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

    Rui Jiang1,3,*, Kaisheng Lai2, Jianping Xu1, Xiang Feng1, Shaoye Wang1, Xiaojian Wang3, Zhe Liu2

    Congenital Heart Disease, Vol.17, No.6, pp. 675-686, 2022, DOI:10.32604/chd.2022.021626

    Abstract Background: The etiology of pulmonary arterial hypertension associated with congenital heart disease (PAHCHD) is complicated and the phenotype is heterogeneous. Genetic defects of NOTCH3 were associated with cerebral disease and pulmonary hypertension. However, the relationship between NOTCH3 mutations and the clinical phenotype has not been reported in CHD-PAH. Methods: We eventually enrolled 142 PAH-CHD patients from Fuwai Hospital. Whole exome sequencing (WES) was performed to screen the rare deleterious variants of NOTCH3 gene. Results: This PAH-CHD cohort included 43 (30.3%) men and 99 (69.7%) women with the mean age 29.8 ± 10.9 years old. The pathogenic or likely pathogenic mutations… More >

  • Open Access

    ARTICLE

    The Class of Atomic Exponential Basis Functions EFupn(x,ω)-Development and Application

    Nives Brajčić Kurbaša*, Blaž Gotovac, Vedrana Kozulić

    CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.1, pp. 65-90, 2023, DOI:10.32604/cmes.2022.021940

    Abstract The purpose of this paper is to present the class of atomic basis functions (ABFs) which are of exponential type and are denoted by . While ABFs of the algebraic type are already represented in the numerical modeling of various problems in mathematical physics and computational mechanics, ABFs of the exponential type have not yet been sufficiently researched. These functions, unlike the ABFs of the algebraic type , contain the tension parameter , which gives them additional approximation properties. Exponential monomials up to the th degree can be described exactly by the linear combination of the functions . The function… More >

  • Open Access

    ARTICLE

    Interactive Trajectory Star Coordinates i-tStar and Its Extension i-tStar (3D)

    Jing He1,2, Haonan Chen3,*, Lingxiao Li4, Yebin Zou5

    CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.1, pp. 211-237, 2023, DOI:10.32604/cmes.2022.020597

    Abstract There are many sources of geographic big data, and most of them come from heterogeneous environments. The data sources obtained in this case contain attribute information of different spatial scales, different time scales and different complexity levels. It is worth noting that the emergence of new high-dimensional trajectory data types and the increasing number of details are becoming more difficult. In this case, visualizing high-dimensional spatiotemporal trajectory data is extremely challenging. Therefore, i-tStar and its extension i-tStar (3D) proposed, a trajectory behavior feature for moving objects that are integrated into a view with less effort to display and extract spatiotemporal… More > Graphic Abstract

    Interactive Trajectory Star Coordinates i-tStar and Its Extension i-tStar (3D)

  • Open Access

    ARTICLE

    Effect of Inclined Tension Crack on Rock Slope Stability by SSR Technique

    Ch. Venkat Ramana*, Niranjan Ramchandra Thote, Arun Kumar Singh

    Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 1205-1214, 2023, DOI:10.32604/iasc.2023.031838

    Abstract The tension cracks and joints in rock or soil slopes affect their failure stability. Prediction of rock or soil slope failure is one of the most challenging tasks in the earth sciences. The actual slopes consist of inhomogeneous materials, complex morphology, and erratic joints. Most studies concerning the failure of rock slopes primarily focused on determining Factor of Safety (FoS) and Critical Slip Surface (CSS). In this article, the effect of inclined tension crack on a rock slope failure is studied numerically with Shear Strength Reduction Factor (SRF) method. An inclined Tension Crack (TC) influences the magnitude and location of… More >

  • Open Access

    REVIEW

    Surface activity of cancer cells: The fusion of two cell aggregates

    IVANA PAJIC-LIJAKOVIC*, MILAN MILIVOJEVIC

    BIOCELL, Vol.47, No.1, pp. 15-25, 2023, DOI:10.32604/biocell.2023.023469

    Abstract A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out the role of these physical… More >

  • Open Access

    ARTICLE

    Intention Estimation of Adversarial Spatial Target Based on Fuzzy Inference

    Wenjia Xiang1, Xiaoyu Li1,*, Zirui He1, Chenjing Su1, Wangchi Cheng2, Chao Lu3, Shan Yang4

    Intelligent Automation & Soft Computing, Vol.35, No.3, pp. 3627-3639, 2023, DOI:10.32604/iasc.2023.030904

    Abstract Estimating the intention of space objects plays an important role in aircraft design, aviation safety, military and other fields, and is an important reference basis for air situation analysis and command decision-making. This paper studies an intention estimation method based on fuzzy theory, combining probability to calculate the intention between two objects. This method takes a space object as the origin of coordinates, observes the target’s distance, speed, relative heading angle, altitude difference, steering trend and etc., then introduces the specific calculation methods of these parameters. Through calculation, values are input into the fuzzy inference model, and finally the action… More >

  • Open Access

    ARTICLE

    Dynamic Risk-Warning of Center Diaphragm and Bench Composite Method During Construction

    Xiaozhong Li*, Caiyun Sun

    Structural Durability & Health Monitoring, Vol.16, No.3, pp. 235-254, 2022, DOI:10.32604/sdhm.2022.013141

    Abstract During the construction of subway tunnels, safety issues should not be ignored, so it is necessary to prevent and resolve the risk in time and accurately. However, there are some shortcomings in the research of risk assessment, such as the subjectivity of initial data or the lack of scientific evaluation model, in order to solve the problem, this paper relies on the Changping section of the Guanhui Intercity Metro, in order to establish a dynamic risk-warning model for the construction process of subway tunnel with the CD-Bench composite method. First, a monitoring plan was equationted according to the specification requirements… More >

  • Open Access

    ARTICLE

    Experimental Study on the Degradation of Bonding Behavior between Reinforcing Bars and Concrete after Corrosion and Fatigue Damage

    Shiqin He*, Jiaxing Zhao, Chunyue Wang, Hui Wang

    Structural Durability & Health Monitoring, Vol.16, No.3, pp. 195-212, 2022, DOI:10.32604/sdhm.2022.08886

    Abstract In marine environments, the durability of reinforced concrete structures such as bridges, which suffer from the coupled effects of corrosion and fatigue damage, is significantly reduced. Fatigue loading can result in severe deterioration of the bonds between reinforcing steel bars and the surrounding concrete, particularly when reinforcing bars are corroded. Uniaxial tension testing was conducted under static loading and fatigue loading conditions to investigate the bonding characteristics between corroded reinforcing bars and concrete. An electrolyte corrosion technique was used to accelerate steel corrosion. The results show that the bond strength was reduced under fatigue loading, although the concrete did not… More >

  • Open Access

    ARTICLE

    Creating Smart House via IoT and Intelligent Computation

    Wen-Tsai Sung1, Sung-Jung Hsiao2,*

    Intelligent Automation & Soft Computing, Vol.35, No.1, pp. 415-430, 2023, DOI:10.32604/iasc.2023.027618

    Abstract This study mainly uses the concept of the Internet of Things (IoT) to establish a smart house with an indoor, comfortable, environmental, and real-time monitoring system. In the smart house, this investigation employed the temperature- and humidity-sensing module and the lightness module to monitor any condition for an intelligent-living house. The data of temperature, humidity, and lightness are transmitted wirelessly to the human-machine interface. The correlation of the weight of the extension theory is used to analyze the ideal and comfortable environment so that people in the indoor environment can feel better thermal comfort and lightness. In this study, improved… More >

  • Open Access

    ARTICLE

    Quaternion Integers Based Higher Length Cyclic Codes and Their Decoding Algorithm

    Muhammad Sajjad1, Tariq Shah1,*, Mohammad Mazyad Hazzazi2, Adel R. Alharbi3, Iqtadar Hussain4

    CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 1177-1194, 2022, DOI:10.32604/cmc.2022.025245

    Abstract The decoding algorithm for the correction of errors of arbitrary Mannheim weight has discussed for Lattice constellations and codes from quadratic number fields. Following these lines, the decoding algorithms for the correction of errors of length cyclic codes over quaternion integers of Quaternion Mannheim weight one up to two coordinates have considered. In continuation, the case of cyclic codes of lengths and has studied to improve the error correction efficiency. In this study, we present the decoding of cyclic codes of length and length 2 (where is prime integer and is Euler phi function) over Hamilton Quaternion integers of Quaternion… More >

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