Jung-Yeon Kim^#, Min Hui Park^#, Kiryeong Kim, Jaechan Leem^*

BIOCELL, Vol.49, No.11, pp. 2147-2166, 2025, DOI:10.32604/biocell.2025.070188 - 24 November 2025

Abstract Background: Cisplatin (CDDP) is a cornerstone chemotherapeutic agent for many solid tumors, but its clinical use is severely limited by dose-dependent nephrotoxicity, which results in acute kidney injury (AKI) in a significant proportion of patients. CDDP-induced AKI involves interconnected mechanisms, including inflammation, oxidative stress, and tubular cell death. In this study, we aimed to investigate the renoprotective effects of esculetin (ES), a natural antioxidant coumarin, in a murine model of CDDP-induced AKI. Methods: Male C57BL/6 mice (8–10 weeks) received a single intraperitoneal injection of CDDP (20 mg/kg) with or without ES (40 mg/kg/day, oral gavage).… More >

Hao Tang^1,2,3, Jianchang Yang^1,2,3, Yunxin Zhou^1,2,3, Jianxin Xu^1,2,3,*, Hua Wang^1,2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.7, pp. 1571-1600, 2025, DOI:10.32604/fdmp.2025.063741 - 31 July 2025

Abstract This research explores the characteristics of boiling in inclined pipes, a domain of great importance in engineering. Employing an experimental visualization technique, the boiling dynamics of deionized water are examined at varying inclination angles, paying special attention to the emerging flow patterns. The findings demonstrate that the inclination angle significantly impacts flow pattern transitions within the 0° to 90° range. As the heat flux rises, bubbles form in the liquid. The liquid’s inertia extends the bubble-wall contact time, thereby delaying the onset of bulk bubble flow. Beyond a 90° inclination, however, the patterning behavior is… More > Graphic Abstract

Binbin Hao¹, Zhenming Liu^1,*, Yajun Deng^1,*, Dongliang Sun¹, Wei Zhang¹, Bo Yu¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.012194

Abstract The tubular fixed bed reactor is widely used in industrial production because of its strong applicability, high stability and easy maintenance. The flow dead zone in the shell of the reactor will significantly affect the overall performance of the reactor. Reducing the flow dead zone in the shell is the main way to optimize the performance of tubular fixed bed reactor. At present, most of the research on the flow dead zone of the reactor is based on the simplified reactor model, the number and size of tubes are far from the industrial requirements. In… More >

Ali Jaber Abdulhamed^*, Aws Al-Akam, Wisam J. Khudhayer, Ali Sabri Allw

Energy Engineering, Vol.121, No.2, pp. 273-290, 2024, DOI:10.32604/ee.2023.045583 - 25 January 2024

Abstract Heat augmentation techniques play a vital role in the heating and cooling processes in industries, including solar collectors and many applications that utilize heat exchangers. Several studies are based on inserting fillers inside the tubes to enhance heat transfer. This investigation considered the effects of twisted tapes with large holes on a tubular heat exchanger’s (HX) heat transmission, pressure drop, and thermal boosting factor. In the experimental section, counter-swirl flow generators used twisted tapes with pairs of 1.0 cm-diameter holes and changes in porosity (R_p) at 1.30% and 2.70%. In the experiments, air was utilized as… More >

Tiezhu Sun^*, Huan Sun, Tingzheng Tang, Yongcheng Yan, Peixuan Li

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.10, pp. 2519-2531, 2023, DOI:10.32604/fdmp.2023.027118 - 25 June 2023

Abstract The so-called indirect evaporative cooling technology is widely used in air conditioning applications. The thermal characterization of tube-type indirect evaporative coolers, however, still presents challenges which need to be addressed to make this technology more reliable and easy to implement. This experimental study deals with the performances of a tube-type indirect evaporative cooler based on an aluminum tube with a 10 mm diameter. In particular, the required tests were carried out considering a range of dry-bulb temperatures between 16°C and 18°C and a temperature difference between the wet-bulb and dry-bulb temperature of 2°C∼4°C. The integrated convective More > Graphic Abstract

Kefan Yang^1,*, Youmin Wang¹, Kexun Fu¹, Jiaqi Chen²

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.5, pp. 1317-1338, 2023, DOI:10.32604/fdmp.2023.024265 - 30 November 2022

Abstract The design of hydro-bulge molds, able to provide hollow parts with special-shaped cross-sections, is still a pretty complicated task (especially for what concerns the design of the related hydraulic system and its “synchronization”). In the present work, this task is addressed through the introduction of a new type of overhead cylinder hydraulic synchronization system, able to correct automatically any deviation from the optimal process. Using the AMESim software, the displacement synchronization curve of the piston rods of the two cylinders is obtained and it is verified that the system is able to implement an automatic More >

CLAIRE ELIZABETH HILLS, ELEFTHERIOS SIAMANTOURAS, PAUL EDWARD SQUIRES^*

BIOCELL, Vol.46, No.4, pp. 937-940, 2022, DOI:10.32604/biocell.2022.018414 - 15 December 2021

Abstract Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and progression. However, these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix, as well as the biophysical and mechanical properties orchestrated by cytoskeletal, membrane and matrix components. To fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function, it is important to consider both biochemical and biophysical attributes of the system being investigated. In this short viewpoint we reflect on our experiences More >

SICONG WANG¹, RUIJIN LIU², QIUYUAN HAN², KAIJIANG YU^3,*

BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027 - 29 September 2021

Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow cytometry. Apoptosis marker proteins… More >

Dana Y. Fuhrman^1,2, Lan Nguyen³, Morgan Hindes³, John A. Kellum²

Congenital Heart Disease, Vol.14, No.6, pp. 963-967, 2019, DOI:10.1111/chd.12862

Abstract Background: There are significant implications for kidney disease in young adults with congenital heart disease. Prior investigations have not focused on the use of urinary tubular biomarkers for the early identification of kidney disease in this growing patient group.
Objective: Determine if young adults with congenital heart disease have differences in the baseline concentration of urinary tubular biomarkers when compared to healthy young adults.
Design/Methods: In a pilot case control study, 30 patients from 18 to 35 years of age with congenital heart disease and a normal serum creatinine were recruited during a routine follow-up visit. In the… More >

Linhong Deng^1,*, Yang Jin², Mingzhi Luo¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 80-80, 2019, DOI:10.32604/mcb.2019.07370

Abstract Airway smooth muscle cells (ASMCs) exists within the bronchial airway wall in a form of spirally winding bundles [1]. This pattern emerges early during embryonic development and is involved in airway branching [2], providing the airway appropriate contractile capacity and resistance to circumferential tension in health or causing excessive airway narrowing in disease such as asthma. Despite its importance, the cause of ASMCs self-organization remains largely a mystery. Previously, we have demonstrated in 2D that ASMCs can sense the curvature in their microenvironment and change behaviors in differentiation, orientation and migration accordingly [3]. Here we… More >