Qiaodong Xu¹, Songgang Gu¹, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan

Oncology Research, Vol.27, No.4, pp. 509-514, 2019, DOI:10.3727/096504018X15278771272963

Abstract Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis and lead to… More >

Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang

Oncology Research, Vol.27, No.4, pp. 449-458, 2019, DOI:10.3727/096504017X15016337254623

Abstract MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR- 125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells. The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and induced cell apoptosis. Furthermore, overexpression of miR-125a-5p could significantly decrease the… More >

Lili Deng^*1, Xue Yang^†1, Jun Fan^*, Yuedi Ding^*, Ying Peng^*, Dong Xu^*, Biao Huang^*‡, Zhigang Hu^†

Oncology Research, Vol.28, No.6, pp. 579-590, 2020, DOI:10.3727/096504020X15942028641011

Abstract Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus is being developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (IL-24) is an important immune mediator, as well as a broad-spectrum tumor suppressor. We constructed a targeted vaccinia virus of Guang9 strain harboring IL-24 (VG9-IL-24) to evaluate its antitumor effects. In vitro, VG9-IL-24 induced an increased number of apoptotic cells and blocked colorectal cancer cells in the G₂ /M phase of the cell cycle. VG9-IL-24 induced apoptosis in… More >

Hongde Li^*†‡, Yueshuo Li^*†‡, Jianmin Hu^*†‡, Sufang Liu^§, Xiangjian Luo^*†‡¶, Min Tang^*†‡, Ann M. Bode^#, Zigang Dong^#**, Xinqi Liu^††, Weihua Liao^‡‡, Ya Cao^{*†‡¶ §§¶¶}

Oncology Research, Vol.28, No.7-8, pp. 763-778, 2020, DOI:10.3727/096504021X16135618512563

Abstract Epstein–Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays an important oncogenic role in the viral latent infection. Recently, increasing evidence indicates that the high expression of LMP1 during EBV lytic cycle is related to the viral lytic replication. However, the mechanism by which LMP1 regulates EBV lytic replication remains unclear. (−)-Epigallocatechin-3-gallate (EGCG) prevents carcinogenesis by directly targeting numerous membrane proteins and effectively inhibits EBV lytic cascade. Here, we demonstrated that LMP1 promotes EBV lytic replication through the downstream signal molecules MAPKs, including ERKs, p38, and JNKs. LMP1 induces the phosphorylation of p53 through MAPKs to enhance the ability of… More >

DONGMEI GAO^1,#, JIAOE CHEN^2,#, HONGZHANG LI^2,*, JUN ZHAO^3,*

BIOCELL, Vol.46, No.10, pp. 2275-2280, 2022, DOI:10.32604/biocell.2022.021008

Abstract Introduction: Human cytomegalovirus (HCMV) is reported to be involved in the occurrence of many human diseases. To further investigate the biological changes of HCMV, we analyzed the relevant factors that affect the autophagy caused by HCMV infection. Methods: Firstly, we cultured human embryonic lung fibroblasts (HELF) cells with HCMV infection, and evaluated the effects of HELF cells infected with different viruses through Enzyme-linked immunoabsorbent assay (ELISA), Real-time quantitative Polymerase Chain Reaction (RT-qPCR), Acridine orange (AO) staining and Western blotting (WB) experiments. Results: Through the above experiments, we found that the combined treatment of HCMV infection and carbamazepine, rapamycin and si-mTOR… More >

Muhammad Umer¹, Mustansar Mubeen², Yasir Iftikhar^2,*, Haider Ali³, Muhammad Zafar-ul-Hye⁴, Rafia Asghar⁵, Mazhar Abbas⁶, Malik Abdul Rehman⁷, Ernesto A. Moya-Elizondo⁸, Yuejun He^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2099-2110, 2022, DOI:10.32604/phyton.2022.022013

Abstract Viral diseases have been studied in-depth for reducing quality, yield, health and longevity of the fruit, to highlight the economic losses. Positive-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit trees. One of the best examples is papaya ringspot virus (PRSV). It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae, Cucurbitaceae and Caricaceae. This virus has a serious threat to the production of papaya, which is famous for its high nutritional and pharmaceutical values. The plant parts such as leaves, latex, seeds, fruits, bark, peel and roots may… More >

Pranav Pushkar¹, Christo Ananth², Preeti Nagrath¹, Jehad F. Al-Amri⁵, Vividha¹, Anand Nayyar^3,4,*

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 1601-1619, 2022, DOI:10.32604/cmc.2022.026205

Abstract The study of viruses and their genetics has been an opportunity as well as a challenge for the scientific community. The recent ongoing SARS-Cov2 (Severe Acute Respiratory Syndrome) pandemic proved the unpreparedness for these situations. Not only the countermeasures for the effect caused by virus need to be tackled but the mutation taking place in the very genome of the virus is needed to be kept in check frequently. One major way to find out more information about such pathogens is by extracting the genetic data of such viruses. Though genetic data of viruses have been cultured and stored as… More >

Anjani Kumar Singha¹, Nitish Pathak^2,*, Neelam Sharma³, Abhishek Gandhar⁴, Shabana Urooj⁵, Swaleha Zubair⁶, Jabeen Sultana⁷, Guthikonda Nagalaxmi⁸

Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 1065-1080, 2022, DOI:10.32604/iasc.2022.024172

Abstract The outburst of novel corona viruses aggregated worldwide and has undergone severe trials to manage medical sector all over the world. A radiologist uses x-rays and Computed Tomography (CT) scans to analyze images through which the existence of corona virus is found. Therefore, imaging and visualization systems contribute a dominant part in diagnosing process and thereby assist the medical experts to take necessary precautions and to overcome these rigorous conditions. In this research, a Multi-Objective Black Widow Optimization based Convolutional Neural Network (MBWO-CNN) method is proposed to diagnose and classify covid-19 data. The proposed method comprises of four stages, preprocess… More >

DOMENICO MARIA CARRETTA^1,§, MARINA DI DOMENICO^2,§, ROBERTO LOVERO³, ROBERTO ARRIGONI⁴, ANGELIKA ELZBIETA WEGIERSKA⁵, MARIAROSARIA BOCCELLINO^2,*, ANDREA BALLINI^2,6,*, IOANNIS ALEXANDROS CHARITOS^7,#, LUIGI SANTACROCE^5,#

BIOCELL, Vol.46, No.8, pp. 1779-1788, 2022, DOI:10.32604/biocell.2022.020009

Abstract The existence of an inflammatory process in the heart muscle, related to a progressive worsening of myocardial function, different etiopathogenetic mechanisms concur and often overlap, thus making the diagnosis and the therapeutic approach complex. As the COVID-19 pandemic progresses, the effects of the disease on the organ systems and in particular on the cardiovascular system are becoming more and more profound. Cardiac involvement is a well-known event with a high percentage of findings in the heart’s magnetic field, even in asymptomatic areas. There are numerous uncertainties regarding their evolution, in the long and short term, due not only to a… More >

MOHAMED SALEM^1,2, MOHAMMAD EL-METWALLY³, WESAMELDIN SABER^4,*, SALLY NEGM^5,6, ATTALLA EL-KOTT^7.8, YASSER MAZROUA^9,10, ABEER MAKHLOUF¹¹, MAHMOUD MOUSTAFA^7,12

BIOCELL, Vol.46, No.8, pp. 1979-1988, 2022, DOI:10.32604/biocell.2022.019301

Abstract Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various systems. Because of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals, viral contagions are amongst the most causative diseases affecting people worldwide. Fungi exemplify a massive source of bioactive molecules as, many fungal secondary metabolities like Oxoglyantrypine, Carneic acid F, Scedapin C, Asteltoxin E, Phomanolide, Norquinadoline A and Quinadoline B have antiviral activity. This review deals with how secondary metabolites of fungi can help in the war against viruses in general and especially… More >