Jun Sung Park¹, Go Hun Seo², Yunha Choi¹, Soojin Hwang¹, Minji Kang³, Hyo-Sang Do³, Young-Hwue Kim⁴, Jeong Jin Yu⁴, Ellen Ai-Rhan Kim⁵, Euiseok Jung⁵, Byong Sop Lee⁵, Jae Suk Baek⁴, Beom Hee Lee^1,6,*

Congenital Heart Disease, Vol.17, No.6, pp. 653-673, 2022, DOI:10.32604/chd.2022.021580

Abstract Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally, multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This study investigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHD and the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromic CHD aged <18 years underwent WES between May 2018 and December 2020 in a single tertiary center, and the association between genetic testing data and extracardiac phenotypes was analyzed. Results: Extracardiac phenotypes were measured as 3.66 ± 3.05 (standard deviation, interquartile range: 2–5)… More > Graphic Abstract

Rofingatul Mubasyiroh^1,*, Indri Yunita Suryaputri¹, Sri Idaiani², Lely Indrawati¹, Tri Wurisastuti¹, Siti Isfandari¹, Nikson Sitorus¹, Enung Nurhotimah³, Felly Philipus Senewe¹

International Journal of Mental Health Promotion, Vol.24, No.5, pp. 725-737, 2022, DOI:10.32604/ijmhp.2022.021452

Abstract The extraordinary situation related to COVID-19 makes people worry about their health, family health, work, finances, and other daily activities. This condition can lead to social unrest, which has consequences for mental health problems. This study aims to determine the mental health consequences at the beginning of the COVID-19 pandemic in Indonesia. This is a cross-sectional study involving a target population aged 18 years and over who had access to electronic communication devices. An online questionnaire was randomly distributed and snowballed throughout 34 provinces in Indonesia. The study was conducted from 2 to 4 May 2020. Non-parametric and multivariate linear… More >

Ya-Sian Chang^*†‡§, Chieh-Min Chang^†‡, Chien-Yu Lin^¶#, Dy-San Chao^†, Hsi-Yuan Huang^†, Jan-Gowth Chang^{*†‡**††}

Oncology Research, Vol.28, No.2, pp. 107-116, 2020, DOI:10.3727/096504019X15698362825407

Abstract The genomic landscape of breast cancer (BC) is complex. The purpose of this study was to decipher the mutational profiles of Taiwanese patients with BC using next-generation sequencing. We performed whole-exome sequencing on DNA from 24 tumor tissue specimens from BC patients. Sanger sequencing was used to validate the identified variants. Sanger sequencing was also performed on paired adjacent nontumor tissues. After genotype calling and algorithmic annotations, we identified 49 deleterious variants in canonical cancer-related genes in our BC cohort. The most frequently mutated genes were PIK3CA (16.67%), FKBP9 (12.5%), TP53 (12.5%), ATM (8.33%), CHEK2 (8.33%), FOXO3 (8.33%), NTRK1… More >

Arisha Patel, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Robert L. Redner, Annie Im, Kathleen A. Dorritie, Alison Sehgal, James Rossetti, Melissa Saul, Daniel Normolle, Konstantinos Lontos, Michael Boyiadzis

Oncology Research, Vol.28, No.7-8, pp. 811-814, 2020, DOI:10.3727/096504020X15965357399750

Abstract Leukemia relapse 5 years after achieving first complete remission (CR1) is uncommon in patients with acute myeloid leukemia (AML). In this study, we evaluated the outcomes of AML patients with late relapse at our institution and reviewed the literature for these patients. The study cohort consisted of nine AML patients with late relapse. The median interval between CR1 and AML relapse was 6.1 years (range: 5.1–16.2 years). At relapse, the karyotype was different from the initial AML diagnosis in 50% of patients. At the time of AML relapse, seven patients received induction chemotherapy and two patients received hypomethylating agents with… More >

Jutarat Tanasansuttiporn¹, Maliwan Oofuvong^1,*, Wirat Wasinwong¹, Voravit Chittithavorn², Pongsanae Duangpakdee², Jirayut Jarutach³, Qistina Yunuswangsa¹

Congenital Heart Disease, Vol.17, No.3, pp. 245-267, 2022, DOI:10.32604/chd.2022.021778

Abstract Background: Studies on predictors of health-related quality of life (HRQOL) in pediatric patients with cyanotic heart disease who are waiting for the next stage and those who have undergone total repair are scarce. Therefore, we aimed to identify such predictors in children who received the modified Blalock–Taussig shunt (MBTS) and those who underwent total repair. Methods: In this historical cohort and concurrent follow-up study, data of children who underwent MBTS at the age of 0–3 years between January 2005 and December 2016 at a super-tertiary care hospital in Southern Thailand were obtained. Children who were alive in December 2017 were… More > Graphic Abstract

Qiang Li^1,*, Lei Xue¹, Xia Lin²

Energy Engineering, Vol.119, No.3, pp. 1059-1074, 2022, DOI:10.32604/ee.2022.017687

Abstract For facing the challenges brought by large-scale renewable energy having access to the system and considering the key technologies of energy Internet, it is very necessary to put forward the location method of distribution network equipment and capacity from the perspective of life cycle cost. Compared with the traditional energy network, the equipment capacity problem of energy interconnected distribution network which involves in electricity network, thermal energy network and natural gas network is comprehensively considered in this paper. On this basis, firstly, the operation architecture of energy interconnected distribution network is designed. Secondly, taking the grid connection location and configuration… More >

Hongyu Mu^1,2,*, Yinyan Wang¹, Hong Teng², Xingtian Zhao², Xiaolong Zhang², Yan Jin², Shiyang Hao², Jingfeng Zhao²

Energy Engineering, Vol.119, No.3, pp. 1103-1116, 2022, DOI:10.32604/ee.2022.017273

Abstract The aerodynamics and heat transfer performance in the rear-mounted automobile cabin have an important influence on the engine's safety and the operational stability of the automobile. The article uses STAR-CCM and GT-COOL software to establish the 3D wind tunnel model and engine cooling system model of the internal combustion engine. At the same time, we established a 3D artificial coupling model through parameter transfer. The research results show that the heat transfer coefficient decreases with the increase of the comprehensive drag coefficient of the nacelle. This shows that the cabin flow field has an important influence on the heat transfer… More >

Hiba Alzoubi¹, Alameen Alsabbah², Rosario Caltabiano³, Giuseppe Broggi^3,*

Oncologie, Vol.24, No.1, pp. 51-63, 2022, DOI:10.32604/oncologie.2022.020890

Abstract The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) improved our understanding of the brain neoplasm biology. In more details, differences between diffuse gliomas that primarily occur in adults and those that primarily occur in children have been identified by the terms “adult-type” and “pediatric-type” diffuse gliomas. More importantly, both diagnostic and grading criteria for adult-type diffuse astrocytomas have been modified, by adopting novel molecular markers: diffuse astrocytomas, IDH-mutant have been grouped into a single entity and graded as CNS WHO grades 2, 3, or 4, with the assignment of Grade 4 in the… More >

Seyyed Mohammad Javad Golhosseini¹, Mohsen Aliabadi^2,*, Rostam Golmohammadi³, Maryam Farhadian⁴, Mehdi Akbari⁵, Morteza Hamidi Nahrani⁶, Mehdi Samavati⁷

Sound & Vibration, Vol.56, No.1, pp. 37-49, 2022, DOI:10.32604/sv.2022.014616

Abstract There is little information about drivers’ body balance responses to combined exposure of noise and vibration. To fill the gap, this study aims to investigate the combined effects of exposure to noise and whole-body vibration (WBV) on the body balance under simulated driving conditions. For this purpose, 30 male participants were exposed to noise level at 85 dB(A) and two vibration levels (0.87 and 1.3 m/s²) in five sessions. The design of the study was repeated-measures, and it attempted to assess the effects of 40 minutes of exposure to noise and/or WBV. Moreover, the participants’ fatigue was measured with the… More >

Lu Cao, Li Huang, Penghe Zhao, Yuling Liu^*

CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.2, pp. 787-803, 2021, DOI:10.32604/cmes.2021.016226

Abstract In view of the frequent waterlogging caused by rapid urbanization and the public’s dissatisfaction with the drainage system, the article based on the concept of the green ecological drainage system, constructed the urban green ecological drainage comprehensive simulation research system, and quickly evaluated pipe network operation and surface water of an industrial park under typical rainfall conditions. The results showed that the drainage capacity of the designed green ecological rainwater drainage system reached 100%, and there was no ponding phenomenon, which indicated that the green ecological rainwater drainage system could effectively solve the practical problems of urban drainage. The green… More >