CHRISTINA LOH¹, YUQI ZHENG¹, ISLAM ALZOUBI², KIMBERLEY L. ALEXANDER^3,4, MAGGIE LEE⁴, WEI-DONG CAI², YANG SONG⁵, KERRIE MCDONALD⁶, ANNA K. NOWAK⁷, RICHARD B. BANATI^8,9, MANUEL B. GRAEBER^1,4,10,*

Oncology Research, Vol.33, No.4, pp. 937-950, 2025, DOI:10.32604/or.2024.056436 - 19 March 2025

Abstract Background: Microglia and brain macrophages contribute significantly to the tumor microenvironment in highly malignant glioblastoma where they are considered important drivers of tumor progression. A better understanding of the role of the brain macrophages present in glioblastoma appears crucial for improving therapeutic outcomes, especially in the context of novel immunotherapeutic approaches. Methods: We investigated the regulation of two well-established markers for microglia and brain macrophages, IBA1 and CD163, in relation to glioblastoma tumor necrosis using immunohistochemistry and modality fusion heatmaps of whole slide images obtained from adjacent tissue sections. Results: IBA1 and CD163 showed remarkable differences… More >

Tanzila Saba¹, Muhammad Mujahid¹, Shaha Al-Otaibi², Noor Ayesha³, Amjad Rehman Khan^1,*

CMC-Computers, Materials & Continua, Vol.82, No.2, pp. 3337-3353, 2025, DOI:10.32604/cmc.2025.060163 - 17 February 2025

Abstract Osteosarcomas are malignant neoplasms derived from undifferentiated osteogenic mesenchymal cells. It causes severe and permanent damage to human tissue and has a high mortality rate. The condition has the capacity to occur in any bone; however, it often impacts long bones like the arms and legs. Prompt identification and prompt intervention are essential for augmenting patient longevity. However, the intricate composition and erratic placement of osteosarcoma provide difficulties for clinicians in accurately determining the scope of the afflicted area. There is a pressing requirement for developing an algorithm that can automatically detect bone tumors with… More >

RYUL KIM^1,#, JOO KYUNG PARK^2,#, MINSUK KWON³, MINAE AN⁴, JUNG YONG HONG¹, JOON OH PARK¹, SUNG HEE LIM^1,*, SEUNG TAE KIM^1,*

Oncology Research, Vol.33, No.1, pp. 57-65, 2025, DOI:10.32604/or.2024.049054 - 20 December 2024

Abstract Background: Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial. Materials and methods: We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy. Results: All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0–25.2) and nine showed stable disease (SD), exhibiting a disease… More >

Yushan Ye¹, Tao Gao¹, Liankun Wang², Junjie Ma², Yingchun Cai², Heng Liu^2,*, Xiaoge Liu²

Structural Durability & Health Monitoring, Vol.19, No.1, pp. 145-166, 2025, DOI:10.32604/sdhm.2024.053756 - 15 November 2024

Abstract To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams, destructive tests were conducted on full-scale pre-stressed concrete beams. Based on the measurement and analysis of beam deflection, strain, and crack development under various loading levels during the research tests, combined with the verification coefficient indicators specified in the codes, the verification coefficients of bridges at different stages of damage can be examined. The results indicate that the T-beams experience complete, incomplete linear, and… More >

Jiangfeng Guo^1,2,3,*, Hongjie Yu¹

Frontiers in Heat and Mass Transfer, Vol.22, No.6, pp. 1575-1595, 2024, DOI:10.32604/fhmt.2024.058179 - 19 December 2024

Abstract Based on the first and second laws of thermodynamics, the heat transfer and flow (thermohydraulic) characteristics of horizontal supercritical pressure CO₂ (S-CO₂) in a circular pipe under heating conditions were investigated numerically. Heating flows in two different diameters (d) of 4 and 6 mm were simulated in pipes with pressures of 8 MPa, mass fluxes (G) of 300 and 400 kg/(m²·s), and heat fluxes (q) of 50, 75 and 100 kW/m². In the d = 4 mm pipe, the peak heat transfer coefficient (h_b) was about 3 times higher than in the d = 6 mm pipe, while the entropy… More > Graphic Abstract

Peng Xiao¹, Qi Zhong², Jingxue Chen¹, Dongyuan Wu¹, Zhen Qin¹, Erqiang Zhou^1,*

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4703-4724, 2024, DOI:10.32604/cmc.2024.049791 - 20 June 2024

Abstract In the intelligent medical diagnosis area, Artificial Intelligence (AI)’s trustworthiness, reliability, and interpretability are critical, especially in cancer diagnosis. Traditional neural networks, while excellent at processing natural images, often lack interpretability and adaptability when processing high-resolution digital pathological images. This limitation is particularly evident in pathological diagnosis, which is the gold standard of cancer diagnosis and relies on a pathologist’s careful examination and analysis of digital pathological slides to identify the features and progression of the disease. Therefore, the integration of interpretable AI into smart medical diagnosis is not only an inevitable technological trend but… More >

Shoukun Xu¹, Lujun Zhang¹, Guangqi Jiang¹, Yining Hua², Yi Liu^1,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3021-3039, 2024, DOI:10.32604/cmc.2023.045853 - 26 March 2024

Abstract This paper focuses on the task of few-shot 3D point cloud semantic segmentation. Despite some progress, this task still encounters many issues due to the insufficient samples given, e.g., incomplete object segmentation and inaccurate semantic discrimination. To tackle these issues, we first leverage part-whole relationships into the task of 3D point cloud semantic segmentation to capture semantic integrity, which is empowered by the dynamic capsule routing with the module of 3D Capsule Networks (CapsNets) in the embedding network. Concretely, the dynamic routing amalgamates geometric information of the 3D point cloud data to construct higher-level feature… More >

Michael A. Rebolledo^1,*, Jane S. Yao², Jason N. Johnson¹, Umar S. Boston³, Benjamin R. Waller III¹

Congenital Heart Disease, Vol.19, No.1, pp. 65-68, 2024, DOI:10.32604/chd.2024.046638 - 20 March 2024

Abstract We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the mid-1960s. We review the clinical and imaging data that support our conclusion. He had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and oxygen. Our case may represent one example of the experimental surgical work done prior to Dr. Adibe Jatene’s description of the first successful arterial switch performed in 1975. More >

Yuxin Wang^1,2,*, Jia Shi^1,2

International Journal of Mental Health Promotion, Vol.26, No.1, pp. 69-80, 2024, DOI:10.32604/ijmhp.2023.044641 - 05 February 2024

Abstract In the 21st century, the rapid growth of the Internet has presented a significant avenue for China to respond actively to the aging population and promote the “Healthy China” strategy in an orderly manner. This study uses panel data from the China Health and Retirement Longitudinal Study (CHARLS) to empirically investigate the influence of Internet use on the mental health of older adults, particularly those who lack intergenerational emotional support and suffer from chronic diseases. This study employs a multi-period difference-in-differences (DID) method and a two-stage instrumental variable approach to address the endogenous problem. Results… More >

Jialing Miao¹, Wei Liao^2,*, Baoguo Xie³

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1147-1157, 2023, DOI:10.32604/ijmhp.2023.030671 - 03 November 2023

Abstract Although employers believe that encouraging and supporting physical exercise activities by purchasing fitness equipment and building sports venues can improve employees’ well-being, the utilization rate is rather low. Since most of the evidence of the well-being promotion in the workplace concentrated on the perspectives of organizational factors and psychosocial factors and focused on the reduction of the negative affect of well-being, it is still an open question whether physical exercise has benefits on both negative and positive affect of wellbeing and who benefits more from physical exercise. Thus, the purpose of this study is to… More >