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  • Open Access


    Controversies in therapeutic application of mesenchymal stem cell-derived secretome


    BIOCELL, Vol.46, No.4, pp. 903-906, 2022, DOI:10.32604/biocell.2022.018200

    Abstract Though mesenchymal stem cells (MSCs) are considered as an important pillar of regenerative medicine, their regenerative potential has been shown to be limited in several pathological conditions. The adverse properties of MSC-based cell therapy have drawn attention to the therapeutic use of MSC-derived secretome. However, MSC-originated exosomes and microvesicles can also possess a significant impact on disease development, including cancer. By interchanging secretome, MSCs can interact with tumor cells and promote mutual exchange/induction of cellular markers. In addition, enzymes secreted into and activated within exosomes can result in the acquisition of new tumor cell properties. More >

  • Open Access


    The effect of exosomes in transferring TET signaling alterations


    BIOCELL, Vol.46, No.3, pp. 579-581, 2022, DOI:10.32604/biocell.2022.017926

    Abstract Ten eleven translocation (TET) enzymes are composed of three representatives: TET1/2/3 which are involved in the hydroxymethylation of methylated cytosines. Because of the wide array of processes that are governed by these epigenetic marks, there have been a wide range of clinical effects associated with TET alterations. Even though many research groups have focused on analyzing the effect of TET alterations within certain cells, few have taken into consideration the effect of TET in the context of intercellular communication. One important entity through which intercellular communication occurs is represented by exosomes. Thus, in the current More >

  • Open Access


    A549/DDP derived exosomes can affect cisplatin chemosensitivity via transporting CXCR4 to A549 cells


    BIOCELL, Vol.46, No.3, pp. 711-720, 2022, DOI:10.32604/biocell.2022.016714

    Abstract The resistance of cancer cells to the anti-cancer drugs is the most important reason that affecting the efficacy of the non-small cell lung cancer (NSCLC) chemotherapy; thus, to explore the underlying mechanism of drug resistance of NSCLC medications is urgently needed for improving the therapeutic efficacy of current anti-NSCLC chemotherapies. The aim of the present study is to explore the roles of exosomes in the chemosensitivity of A549 cells and the related mechanism. A549 cells and cisplatin resistant cell line A549/DDP derived exosomes were isolated, and the expressions of CXCR4 were compared. Then, after cisplatin… More >

  • Open Access


    Design of Human Adaptive Mechatronics Controller for Upper Limb Motion Intention Prediction

    R. Joshua Samuel Raj1,*, J. Prince Antony Joel2, Salem Alelyani3, Mohammed Saleh Alsaqer3, C. Anand Deva Durai4

    CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 1171-1188, 2022, DOI:10.32604/cmc.2022.021667

    Abstract Human Adaptive Mechatronics (HAM) includes human and computer system in a closed loop. Elderly person with disabilities, normally carry out their daily routines with some assistance to move their limbs. With the short fall of human care takers, mechatronics devices are used with the likes of exoskeleton and exosuits to assist them. The rehabilitation and occupational therapy equipments utilize the electromyography (EMG) signals to measure the muscle activity potential. This paper focuses on optimizing the HAM model in prediction of intended motion of upper limb with high accuracy and to increase the response time of… More >

  • Open Access


    M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells


    BIOCELL, Vol.46, No.2, pp. 495-503, 2022, DOI:10.32604/biocell.2022.015214

    Abstract Differentiated macrophages have been proven to participate in the development of mesenchymal stem cells in different tissues. However, the regulatory processes remain obscure. Exosomes, which are key secretions of macrophages, have attracted increasing attention. Therefore, macrophage-derived exosomes may modulate the development of Bone marrow mesenchymal stem cells (BMMSCs). Different culture conditions were used to induce M1 polarization in THP1 cells. Subsequently, exosomes derived from unpolarized (M0) and polarized (M1) macrophages were isolated, BMMSCs were cultured with normal complete medium or inductive medium supplemented with M0 or M1 derived exosomes, and the osteogenic capacity of the… More >

  • Open Access


    Lysophosphatidylcholine acyltransferase 1 is involved in the regulation of exosome secretion and uptake in colorectal cancer cells


    BIOCELL, Vol.46, No.2, pp. 453-462, 2022, DOI:10.32604/biocell.2021.015340

    Abstract Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a phospholipid acyltransferase that promotes phospholipid synthesis and plasma membrane reconstruction. Exosomes play an important role in tumor metastasis. The release and uptake of exosomes are key steps of their functions and depend on plasma membrane fusion and plasma membrane receptors, respectively. The purpose of this study was to explore whether LPCAT1-induced plasma membrane remodeling would change the secretion and uptake behavior of exosomes in tumor cells. We first confirmed the abnormally high expression of LPCAT1 in colorectal cancer cells by quantitative real-time PCR (qPCR) and Western blot analysis. Then,… More >

  • Open Access


    Revisiting miR-155 in intervertebral disc degeneration: blood cell signature and local cell-free profiles


    BIOCELL, Vol.46, No.2, pp. 511-517, 2022, DOI:10.32604/biocell.2021.016194

    Abstract We unraveled the expression profiles of coding-noncoding RNAs in intervertebral disc degeneration (IDD). However, it remains elusive regarding miR-155 expression in peripheral blood mononuclear cells (PBMCs) and local extracellular space in IDD. The study aimed for investigating the miR-155 expression of PBMCs, extracellular miRNAs (ex-miRNAs) of human nucleus pulposus (NP) tissues, and morphological changes of cell death in the IDD process. Here, we harvested peripheral blood and NP samples from scoliosis and IDD patients as control and degenerative groups, respectively. Then standard Ficoll density-gradient centrifugation was used to isolate PBMCs. The two subpopulations of PBMCs… More >

  • Open Access


    An Intent-Driven Closed-Loop Platform for 5G Network Service Orchestration

    Talha Ahmed Khan, Khizar Abbas, Afaq Muhammad, Wang-Cheol Song*

    CMC-Computers, Materials & Continua, Vol.70, No.3, pp. 4323-4340, 2022, DOI:10.32604/cmc.2022.017118

    Abstract The scope of the 5G network is not only limited to the enhancements in the form of the quality of service (QoS), but it also includes a wide range of services with various requirements. Besides this, many approaches and platforms are under the umbrella of 5G to achieve the goals of end-to-end service provisioning. However, the management of multiple services over heterogeneous platforms is a complex task. Each platform and service have various requirements to be handled by domain experts. Still, if the next-generation network management is dependent on manual updates, it will become impossible… More >

  • Open Access


    Development of A Low-Cost Exoskeleton for Rehabilitation and Mobility

    Muhatasim Intisar1, Mohammad Monirujjaman Khan1,*, Mehedi Masud2, Mohammad Shorfuzzaman2

    Intelligent Automation & Soft Computing, Vol.31, No.1, pp. 101-115, 2022, DOI:10.32604/iasc.2022.019083

    Abstract Paralysis is detrimental to people in catastrophic ways: losing income opportunities, becoming a burden to their friends and family, further physical deterioration, and the combination of these occurrences can often lead to depression. In third world countries, suffering from paralysis can be extra deleterious, where a large proportion of the population is engaged in some form of physical labor. The number of people exposed to paralysis risk factors is also increasing, with more and more people having hypertension, smoking, and other abnormalities. Besides, low workplace safety precautions may lead to an increased risk of spinal… More >

  • Open Access


    Real-Time analysis of exosome secretion of single cells with single molecule imaging


    BIOCELL, Vol.45, No.6, pp. 1449-1451, 2021, DOI:10.32604/biocell.2021.017607

    Abstract The exosome-mediated response can promote or restrain the diseases by regulating the intracellular pathways, making the exosome become an effective marker for diagnosis and therapeutic control at the single-cell level. However, real-time analysis is hard to be achieved with traditional approaches because the exosomes usually need to be enriched by ultracentrifugation for a measurable signal-to-noise ratio. Recently developed label-free single-molecule imaging approaches may become an real-time quantitative tool for the analysis of single exosomes and related secretion behaviors of single living cells owing to their extreme sensitivity. More >

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