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  • Open Access

    ARTICLE

    Bioactive Potential of Calophyllum inophyllum: Phytochemical Profiles, Biological Activities, and In Silico Pharmacokinetic Predictions

    Luksamee Vittaya1,*, Chakhriya Chalad1, Sittichoke Janyong2, Nararak Leesakul3

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4091-4115, 2025, DOI:10.32604/phyton.2025.074891 - 29 December 2025

    Abstract Calophyllum inophyllum is a tropical plant that could have useful medicinal properties for pharmaceutical and cosmetic applications. The present study extracted the flower, fruit, leaf, twig, and bark of the plant by maceration in different organic solvents. The correlation between bioactive compounds and their biological activities was investigated, with emphasis on their therapeutic relevance through in silico pharmacokinetic predictions using SwissADME. Qualitative and quantitative analyses were conducted to determine the total phenolic, flavonoid, and saponin contents of the extracts. Spectral analysis of the extracts revealed –OH, C=O, C=C, and C–H functional groups. The antioxidant activity of the… More > Graphic Abstract

    Bioactive Potential of <i>Calophyllum inophyllum</i>: Phytochemical Profiles, Biological Activities, and <i>In Silico</i> Pharmacokinetic Predictions

  • Open Access

    ARTICLE

    Enhancing anticancer, antioxidant, and antibacterial activities of chalcogen-based SnSe nanoparticles synthesized through the co-precipitation method

    H. A. Rather1,*, J. B. A. Wahid2, M. A. Dar3, L. Guganathan4, U. A. Dar5, P. Arularasan6, S. E. I. Yagoub7, L. G. Amin7

    Chalcogenide Letters, Vol.22, No.5, pp. 461-468, 2025, DOI:10.15251/CL.2025.225.461

    Abstract SnSe powdered nanoparticles (NPs) are prepared using the co-precipitation method. The powdered NPs were studied using X-ray diffraction (XRD), UV-absorbance spectroscopy, and scanning electron microscopy (SEM) characterization techniques. The XRD result indicates that NPs are orthorhombic with a crystalline size of 4 nm for TS-1, 6 nm for TS-2, and 13 nm for TS-3, respectively. The SEM images show the surface morphology of the prepared NPs is not fully spherical, but semi-flower-like. The optical properties of the powdered NPs are found by UV-Vis absorbance spectroscopy, in which the highest absorbance was found between 200 nm More >

  • Open Access

    ARTICLE

    Facile Preparation of Robust Peach Gum Polysaccharide with Remarkably Enhanced Antibacterial and Antioxidant Performance

    Mengting Huang, Meiting Lu, Li Yang, Jiwen Long, Li Zhou*

    Journal of Renewable Materials, Vol.13, No.10, pp. 2077-2090, 2025, DOI:10.32604/jrm.2025.02025-0122 - 22 October 2025

    Abstract Peach gum polysaccharide (PGP), a readily available natural polysaccharide, boasts substantial potential across diverse applications, yet its practical utility is severely limited by its vulnerability to bacterial growth and limited antioxidant activity. Herein, we introduced a simple and effective method to enhance the antibacterial and antioxidant properties of PGP by conjugating it with salicylic acid (SA). Cytotoxicity evaluation results confirmed that the resulting PGP-SA retains the excellent biocompatibility of PGP. Notably, PGP-SA demonstrates outstanding antibacterial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, outperforming non-modified PGP. Its antibacterial mechanism is hypothesized to stem from… More > Graphic Abstract

    Facile Preparation of Robust Peach Gum Polysaccharide with Remarkably Enhanced Antibacterial and Antioxidant Performance

  • Open Access

    REVIEW

    Design of Nanostructured Surfaces and Hydrogel Coatings for Anti-Bacterial Adhesion

    Nanpu Cao1, Huan Luo1, Song Yue1, Yong Chen1, Mao Xu1, Pu Cao1, Tao Xin1, Hongying Luo1, Fa Zhang2,*

    Journal of Polymer Materials, Vol.42, No.3, pp. 661-675, 2025, DOI:10.32604/jpm.2025.067313 - 30 September 2025

    Abstract This review systematically summarizes recent advancements in the design of antibacterial hydrogels and the surface-related factors influencing microbial adhesion to polymeric materials. Hydrogels, characterized by their three-dimensional porous architecture and ultra-high water content, serve as ideal platforms for incorporating antibacterial agents (e.g., metal ions, natural polymers) through physical/chemical interactions, enabling sustained release and enhanced antibacterial efficacy. For traditional polymers, surface properties (e.g., roughness, charge, superhydrophobicity, free energy, nanoforce gradients) play critical roles in microbial adhesion. Modifying the surface properties of polymers through surface treatment can regulate antibacterial performance. In particular, by referencing the micro/nanostructures found More >

  • Open Access

    ARTICLE

    Sustainable Removal of Cu2+ and Pb2+ Ions via Adsorption Using Polyvinyl Alcohol/Neem Leaf Extract/Chitosan (From Shrimp Shells) Composite Films

    Deepti Rekha Sahoo, Trinath Biswal*

    Journal of Polymer Materials, Vol.42, No.3, pp. 811-835, 2025, DOI:10.32604/jpm.2025.067022 - 30 September 2025

    Abstract The purpose of this research work is to determine the removal efficiency of Cu2+ and Pb2+ ions using polyvinyl alcohol/neem leaf extract/chitosan (PVA/NLE/CS) composite films as adsorbent materials from an aqueous medium, with respect to pH, contact time, and adsorbent dosage. The synthesized composite material was characterized using Fourier Transform Infrared (FTIR) spectroscopy, thermogravimetric analysis-Derivative Thermogravimetry (TGA-DTG), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy-Energy Dispersive X-ray Spectroscopy (SEM-EDX). The antibacterial activity and swelling response of the material were studied using suitable methodologies. The FTIR study confirmed the interactions among PVA, chitosan, and… More >

  • Open Access

    PROCEEDINGS

    Antibacterial Surface Modification and Its Application on Janus Wearable Devices

    Kaiwei Tang1,2,*, Xiufeng Wang1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.010499

    Abstract The prolonged health monitoring using wearable technology faces challenges stemming from perspiration, including bacterial proliferation, compromised adhesion, signal quality deterioration, and user discomfort. Notably, excessive sweat fosters bacterial colonization, escalating infection risks, and compromising biomarker analysis. Existing antibacterial approaches, unfortunately, risk disrupting the delicate balance of skin microbiota. To address this, we’ve developed a Janus patch featuring Zn-Al layered double hydroxide (LDH) modification, which boasts sustained antibacterial properties while preserving the epidermal microecology. It integrates a hydrophobic LDH fabric that mechanically eradicate bacteria via a nanoknife effect, and a laser-engraved medical adhesive with microholes for More >

  • Open Access

    ARTICLE

    Synergistic anticancer and antibacterial effects of novel regimens of phytopolyphenols and repurposing drugs on cultured cells

    YA-LING YEH1, YING-JAN WANG1, SHOEI-YN LIN-SHIAU2,3,*

    Oncology Research, Vol.33, No.7, pp. 1781-1796, 2025, DOI:10.32604/or.2025.063717 - 26 June 2025

    Abstract Background: The increasing incidence of cancers and infectious diseases worldwide presents a significant public health challenge that requires immediate intervention. Our strategy to tackle this issue involves the development of pharmaceutical formulations that combine phytopolyphenols (P), targeted drugs (T), and metal ions (M), collectively referred to as PTM regimens. The diverse pharmacological properties of PTM regimens are hypothesized to effectively reduce the risk factors associated with both cancers and infectious diseases. Methods: The effects of the pharmaceutical agents on the proliferation of cultured cancer cells and pathogens were assessed after 72 h and 48 h,… More >

  • Open Access

    ARTICLE

    Antibacterial, Antioxidant, and Anti-Inflammatory Activities of Artemisia dracunculus Essential Oil: Estragole as the Major Bioactive Compound

    Ammar Attar*

    Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1225-1237, 2025, DOI:10.32604/phyton.2025.063207 - 30 April 2025

    Abstract Artemisia dracunculus L., or tarragon, is a perennial herb from the Asteraceae family that is extensively cultivated for its aromatic leaves, which are valued for its preventative and therapeutic properties in both cookery and traditional medicine. This study aims to investigate the antibacterial, antioxidant, and anti-inflammatory properties of A. dracunculus (tarragon) essential oil (ADEO), with estragole (57.23%) identified as the major compound through gas chromatography-mass spectrometry (GC-MS) analysis. ADEO exhibited varying degrees of antibacterial activity, with Escherichia coli showing higher resistance (inhibition zone (IZ) = 14.7 ± 0.58 mm, minimum inhibitory concentration (MIC) = 2% and minimum bactericidal… More >

  • Open Access

    ARTICLE

    Aphicidal and Antimicrobial Activities of Salvia rosmarinus Essential Oil and Its Major Compound, 1,8-Cineole

    Ghizlane Houzi1, Aimad Allali2,3,*, Amine Elbouzidi4,*, Mohamed Taibi4, Mohamed Chebaibi3,5, Ben Khada Zineb6, Ramzi A. Mothana7, Mohammed F. Hawwal7, Rachid Flouchi3,8, Abdeslam Asehraou9, Amal Lahkimi2, Soad Khal-Layoun1

    Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1239-1251, 2025, DOI:10.32604/phyton.2025.063021 - 30 April 2025

    Abstract This work uses GC-MS to analyze the bioactive compounds of Salvia rosmarinus essential oils (SREO) and evaluates their antibacterial, antifungal, and insecticidal effects, as well as the major component, 1,8-cineole. Chemical analysis identified 16 compounds accounting for 99.19% of the oil’s total content, with 1,8-cineole (33.17%), camphor (16.53%), α-pinene (14.46%), and camphene (8.14%) as the major constituents. Antimicrobial activities were assessed against pathogenic strains using minimal inhibit concentration (MIC) and minimum bactericidal concentration (MBC) assays. SREO exhibited a minimum MIC of 0.128% against P. aeruginosa, while 1,8-cineole showed a minimum MIC of 2.06% against the same strain,… More >

  • Open Access

    ARTICLE

    Biological Potential and Chemical Characterization of Juniperus oxycedrus Leaves and Seed Cones

    Mohamed reda Kachmar1,2, Toufik Bouddine3, Abdelaziz Ed-dra4,5, Safaâ Kachmar6, Hammou Anarghou7,8, Sulaiman Mohammed Alnasser9, Fahad M. Alshabrmi10, Samiah Hamad Al-Mijalli11,*, Emad M. Abdallah12,*, Nidal Naceiri Mrabti13, Abdelmounaim Laabar14, Mourad Chikhaoui15, Galman Aziz1,4, Lhoussain Hajji3, Said Chakir2

    Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 657-677, 2025, DOI:10.32604/phyton.2025.062289 - 31 March 2025

    Abstract Juniperus oxycedrus (J. oxycedrus) is a traditional culinary spice and medicinal herb with a longstanding history of ethnopharmacological applications across diverse cultures. While prior research has explored the biological activities and phytochemical constituents of extracts derived from its leaves and seed cones, the present study systematically investigates their mineral and phenolic profiles alongside their multifunctional bioactive potential. Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis revealed a substantial abundance of essential macro- and microelements. Reversed-phase high-performance liquid chromatography (RP-HPLC) further identified high concentrations of phenolic acids (e.g., p-coumaric acid) and flavonoids (e.g., rutin and quercetin). The extracts exhibited More >

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