Sipawath Khamplod^1,2, Yodying Kaolawanich^1,2, Khemajira Karaketklang³, Nithima Ratanasit^1,2,*

Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631

Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause mortality. Univariable and multivariable analyses… More > Graphic Abstract

Fu Guan^1,*, Matthias Gass², Florian Berger², Heiko Schneider¹, Firat Duru^1,3, Thomas Wolber^1,3,*

Congenital Heart Disease, Vol.19, No.1, pp. 85-92, 2024, DOI:10.32604/chd.2024.047266

Abstract Aims: Although the application of ultrasound-guided vascular puncture and Z-stitch hemostasis to manage femoral access has been widely utilized, there is limited data on this combined application in adult congenital heart disease (ACHD) patients undergoing electrophysiological (EP) procedures. We sought to evaluate the safety and efficacy of ultrasound-guided puncture and postprocedural Z-stitch hemostasis for ACHD patients undergoing EP procedures. Methods and Results: The population of ACHD patients undergoing transfemoral EP procedures at the University of Zurich Heart Center between January 2019 and December 2022 was observed and analyzed. During the study period, femoral access (left/right, arterial/venous) was performed under real-time… More >

Albert Osom¹, Krysta S. Barton², Katie Sexton^3,4, Lyndia Brumback¹, Joyce P. Yi-Frazier⁴, Abby R. Rosenberg^5,6, Ruth Engelberg⁷, Jill M. Steiner^8,*

Congenital Heart Disease, Vol.19, No.1, pp. 33-48, 2024, DOI:10.32604/chd.2024.046656

Abstract Social determinants of health (SDOH) affect quality of life. We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease (ACHD). Secondary analysis of data from two complementary studies: a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August 2021. Resilience was assessed through CD-RISC10 score (range 0–40, higher scores reflect greater self-perceived resilience) and interview responses. Sociodemographic and SDOH (education, employment, living situation, monetary stability, financial dependency, area deprivation index) data were collected by healthcare record review and self-report. We used linear regression with robust standard errors to analyze survey data and… More > Graphic Abstract

Michael A. Rebolledo^1,*, Jane S. Yao², Jason N. Johnson¹, Umar S. Boston³, Benjamin R. Waller III¹

Congenital Heart Disease, Vol.19, No.1, pp. 65-68, 2024, DOI:10.32604/chd.2024.046638

Abstract We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the mid-1960s. We review the clinical and imaging data that support our conclusion. He had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and oxygen. Our case may represent one example of the experimental surgical work done prior to Dr. Adibe Jatene’s description of the first successful arterial switch performed in 1975. More >

Molly Clarke^1,*, Karin Hamann², Nancy Klein², Laura Olivieri³, Yue-Hin Loke²

Congenital Heart Disease, Vol.19, No.1, pp. 5-17, 2024, DOI:10.32604/chd.2024.046328

Abstract Background: Patients with congenital heart disease (CHD) will transition to lifelong adult congenital cardiac care. However, their structural heart disease is challenging to convey via two-dimensional drawings. This study utilized a tele-educational environment, with personalized three-dimensional (3D) modeling and health Details (3D + Details = “4D”), to improve actual and perceived knowledge, both important components of transition readiness in CHD patients. Methods: Participants aged ≥13 years with a history of CHD and cardiac magnetic resonance imaging (MRI) studies were eligible. Cardiac MRI datasets were then used to segment and create 3D heart models (using Mimics, Materialize Inc.). Participants first completed… More >

Cheryl Dickson^1,2,4, Danielle Osborn¹, David Baker^1,4, Judith Fethney³, David S. Celermajer^1,4, Rachael Cordina^1,4,*

Congenital Heart Disease, Vol.19, No.1, pp. 49-63, 2024, DOI:10.32604/chd.2023.044874

Abstract Background: Much has been written about the loss to follow-up in the transition between pediatric and adult Congenital Heart Disease (CHD) care centers. Much less is understood about the loss to follow-up (LTF) after a successful transition. This is critical too, as patients lost to specialised care are more likely to experience morbidity and premature mortality. Aims: To understand the prevalence and reasons for loss to follow-up (LTF) at a large Australian Adult Congenital Heart Disease (ACHD) centre. Methods: Patients with moderate or highly complex CHD and gaps in care of >3 years (defined as LTF) were identified from a… More >

Xuming Mo^1,*, Wei Cai^2,*, Jirong Qi¹, Zhuoming Xu³, Ying Wang⁴, Weihui Yan⁴, Shoujun Li⁵, Nianguo Dong⁶, Xinxin Chen⁷, Jinfen Liu³, Qiang Shu⁸, Jimei Chen⁹, Haibo Zhang³, Hao Zhang¹⁰, Quansheng Xing¹¹, Qi An¹², Xiaofeng Li¹³, Xu Wang¹⁴, Yan He¹⁵, Junwu Su¹⁶, Taibing Fan¹⁷, Teng Ming¹⁸, Weibing Tang¹⁹, Li Hong²⁰, Jinghao Zheng³, Ming Ye²¹, Guocheng Sun²², Yiqun Ding²³, Liang Tao²⁴, Yifeng Yang²⁵, Zhongshi Wu²⁵, Hua Cao²⁶, Qiang Wang¹⁶, Keming Yang⁵, Libing Zhang²⁷, Ping Wen²⁸, Yanqin Cui²⁹, Bo Zhai³⁰, Yong Zou¹⁸, Qingya Tang³¹, Rui Chen¹¹, Chun Wu³², Zhiyu Feng³³, Caixia Liu³⁴, Yaping Mi²¹, Rufang Zhang³⁵, Ke Lin¹², Xin Li³⁶, Mingan Pi³⁷, Xiangming Fan⁸, Shanshan Shi³⁸, Peng Huang³⁹, Zhengxia Pan³², Jiafeng Qi⁴⁰, Renwei Chen⁴¹, Shuguang Tao⁴², Yaqin Shu¹, Huifeng Zhang²¹, Lan Jiang¹, Min Da¹, Nishant Patel¹, Liang Hu¹, Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association, Parenteral Enteral Nutrition Society of Chinese Medical Association

Congenital Heart Disease, Vol.18, No.6, pp. 571-593, 2023, DOI:10.32604/chd.2024.048939

Abstract The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pediatric nutrition guidelines or consensus worldwide, the management of congenital heart disease, and the results of multi-center clinical nutrition research for congenital heart disease following the first Chinese consensus edition of 2016. The consensus was also shaped by the results of three discussion sessions and two questionnaires conducted by the 13-member collaboration group. This process was informed by both clinical guidelines and expert consensus. The quality of literature, both in English and Chinese, and the level of recommendations were evaluated using the… More >

Ziguang Song^1,2, Jiangbo Yu¹, Mengmeng Wang³, Weitao Shen⁴, Chengcheng Wang¹, Tianyi Lu¹, Gaojun Shan¹, Guo Dong¹, Yiru Wang¹, Jiyi Zhao^1,*

Congenital Heart Disease, Vol.18, No.6, pp. 693-701, 2023, DOI:10.32604/chd.2024.048081

Abstract CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression. The development of human diseases involves important regulatory roles of RNAs, and expression profiling data can reflect the underlying etiology of inherited diseases. Hence, collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases. CHDTEPDB stores the expression profiles of over 200 sets of 7… More >

Aisa Zulibiya^1,2,#, Jing Wen^3,#, Huiqing Yu^3,#, Xiaoming Chen³, Lei Xu³, Xiao Ma^1,2, Baojian Zhang^1,2,*

Congenital Heart Disease, Vol.18, No.6, pp. 611-625, 2023, DOI:10.32604/chd.2023.047689

Abstract Background: Tetralogy of Fallot (TOF) is a very common cyanotic congenital heart disease. Endothelial-to-mesenchymal transition (EndoMT) is recognized as a physiological mechanism involved in embryonic heart development and endothelial formation. However, there is still a gap in the reports related to the mechanism of EndoMT development in TOF. Methods: First, transcriptomic data of single cell nuclei of TOF and Donor were obtained based on the Gene Expression Omnibus (GEO) database, and the data were normalized and clustered by dimensionality reduction using the Seurat package. Subsequently, differentially expressed genes (DEGs) between TOF and Donor were screened using the “FindMarkers” function, and… More >

Dian Kesumarini^1,2, Yunita Widyastuti³, Cindy Elfira Boom¹, Lucia Kris Dinarti^4,*

Congenital Heart Disease, Vol.18, No.6, pp. 671-678, 2023, DOI:10.32604/chd.2023.044746

Abstract Tetralogy of Fallot (TOF) with total anomalous pulmonary vein connections (TAPVC) is a rare type of complex congenital heart disease among all TOF cases. Co-presentation of major aortopulmonary collateral arteries (MAPCAs) compensates for the lack of central pulmonary blood flow and decreases the severity of right-to-left shunting in TOF. We present a case of a 2-year-old child with complex diagnoses of TOF, TAPVC, a large secundum atrial septal defect (ASD), and intraoperatively identified MAPCAs. She underwent surgery to repair the TAPVC, valve-sparing reconstruction of the right ventricular outflow tract, interventricular defect closure, and the creation of patent foramen ovale (PFO).… More >