A. Sumathi^1,*, S. Meganathan¹, B. Vijila Ravisankar²

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3109-3126, 2021, DOI:10.32604/cmc.2021.017612

Abstract Gestational Diabetes Mellitus (GDM) is one of the commonly occurring diseases among women during pregnancy. Oral Glucose Tolerance Test (OGTT) is followed universally in the diagnosis of GDM diagnosis at early pregnancy which is costly and ineffective. So, there is a need to design an effective and automated GDM diagnosis and classification model. The recent developments in the field of Deep Learning (DL) are useful in diagnosing different diseases. In this view, the current research article presents a new outlier detection with deep-stacked Autoencoder (OD-DSAE) model for GDM diagnosis and classification. The goal of the proposed OD-DSAE model is to… More >

Mohammed Ali Ashehri^*

Phyton-International Journal of Experimental Botany, Vol.90, No.6, pp. 1749-1762, 2021, DOI:10.32604/phyton.2021.016290

Abstract In most of Arabian courtiers Rhazya stricta is extensively utilized in public medicine for several diseases treatment. In this study, crude alkaloid extract of R. stricta (CAERS) coated with silver nanoparticles (CAERS-AgNPs) as potential treatment against diabetes in DM animal model was evaluated. Swiss albino male rats (n = 80) were injected with STZ to induce Diabetes Mellitus type-2 (DM). DM-rats were injected different doses of CAERS or CAERS-nanoparticles (CAERS-NPs) for 2 months. The results exhibited that mRNA expression of insulin and insulin receptor was down-regulated, activity levels of antioxidant enzymes were decreased, generation of ROS mediated DNA adducts and apoptosis in… More >

Shabib Aftab^1,2, Saad Alanazi³, Munir Ahmad¹, Muhammad Adnan Khan^4,*, Areej Fatima⁵, Nouh Sabri Elmitwally^3,6

CMC-Computers, Materials & Continua, Vol.68, No.1, pp. 1341-1357, 2021, DOI:10.32604/cmc.2021.016814

Abstract Diabetes mellitus, generally known as diabetes, is one of the most common diseases worldwide. It is a metabolic disease characterized by insulin deficiency, or glucose (blood sugar) levels that exceed 200 mg/dL (11.1 ml/L) for prolonged periods, and may lead to death if left uncontrolled by medication or insulin injections. Diabetes is categorized into two main types—type 1 and type 2—both of which feature glucose levels above “normal,” defined as 140 mg/dL. Diabetes is triggered by malfunction of the pancreas, which releases insulin, a natural hormone responsible for controlling glucose levels in blood cells. Diagnosis and comprehensive analysis of this… More >

Daniel Sierra-Sosa^1,*, Juan D. Arcila-Moreno², Begonya Garcia-Zapirain³, Adel Elmaghraby¹

CMC-Computers, Materials & Continua, Vol.67, No.2, pp. 1849-1861, 2021, DOI:10.32604/cmc.2021.013196

Abstract Quantum Machine Learning (QML) techniques have been recently attracting massive interest. However reported applications usually employ synthetic or well-known datasets. One of these techniques based on using a hybrid approach combining quantum and classic devices is the Variational Quantum Classifier (VQC), which development seems promising. Albeit being largely studied, VQC implementations for “real-world” datasets are still challenging on Noisy Intermediate Scale Quantum devices (NISQ). In this paper we propose a preprocessing pipeline based on Stokes parameters for data mapping. This pipeline enhances the prediction rates when applying VQC techniques, improving the feasibility of solving classification problems using NISQ devices. By… More >

Jaswinder Kaur¹, Manish Vyas², Joginder Singh¹, Ram Prasad^3,*, Jeena Gupta^1,*

Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 795-803, 2020, DOI:10.32604/phyton.2020.09420

Abstract In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin in managing disorders other than… More >

Zahra Alimanesh¹, Zeynab Alimanesh¹, Fatemeh Davari², Saeedeh Shadmehri³, Mozhgan Ahmadi³, Seyed Ali Hosseini⁴, Sepideh Dolati^5,*, Alemeh Hariri Far⁶

Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 155-163, 2020, DOI:10.32604/mcb.2020.011532

Abstract Diabetes mellitus (DM) disease can affect process of apoptosis by increasing oxidative stress, nevertheless exercise and crocin can improve apoptosis; therefore present study aimed to investigate the effect of continued training with crocin on apoptosis markers in liver tissue of diabetic rats. In this experimental study 32 diabetic rats based on fasting glucose divided into four groups of eight rats including: 1) sham, 2) training, 3) crocin, and 4) training with crocin also for investigate the effect of DM induction on apoptosis markers, eight healthy rats assigned in healthy control group. During eight weeks groups 2 and 4 ran 60… More >

MENGSHU ZHAO¹, PINGSHI GAO¹, LIANG TAO¹, JINGJING WEN¹, LEI WANG¹, YUGUO YI¹, YUXIN CHEN², JUNSONG WANG¹, XI XU¹, JIANFA ZHANG¹, DAN WENG^1,*

BIOCELL, Vol.44, No.3, pp. 353-361, 2020, DOI:10.32604/biocell.2020.08955

Abstract As a natural analog of resveratrol, piceatannol (Pic) exhibits good antioxidant and anti-inflammatory activities in different disease models. However, the role of Pic in type 1 diabetes mouse model has not been reported yet. In this study, we investigated the in vivo effect of Pic in streptozotocin (STZ)-induced type 1 diabetic mice. Mice were injected with STZ to establish the type 1 diabetes mellitus (T1DM) model. After stable hyperglycemia was achieved, mice were then orally treated with Pic (40 mg/kg b.w., i.g.) for 30 days. The results indicated that Pic supplementation efficiently alleviated the typical symptoms associated with T1DM, including… More >

Maria Fedchenko, Zacharias Mandalenakis, Helena Dellborg, Görel Hultsberg‐Olsson, Anna Björk, Peter Eriksson, Mikael Dellborg

Congenital Heart Disease, Vol.14, No.4, pp. 549-558, 2019, DOI:10.1111/chd.12785

Abstract Background: The aging patient with adult congenital heart disease (ACHD) faces the risk of developing atherosclerotic disease. Patients with coarctation of the aorta (CoA) are especially vulnerable because of an inherent high risk of developing hy‐ pertension. However, data on the prevalence of other cardiovascular risk factors are scarce. Therefore, this study aimed to describe the prevalence of traditional cardio‐ vascular risk factors (diabetes, hypertension, hyperlipidemia, smoking, obesity, and sedentary lifestyle) in adult patients with CoA.
Methods: Patients with CoA who were registered at the ACHD clinic in Gothenburg were asked to participate in a comprehensive cardiovascular risk assessment. This… More >

Yuanliang Tang^{1, 2}, Lizhong Mu¹, Ying He^{1, *}

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.2, pp. 281-296, 2020, DOI:10.32604/fdmp.2020.06760

Abstract The aim of this study is to develop a model of fluid and heat transfer in a biological tissue taking into account the exact structure of the related microvascular network, and to analyze the influence of structural changes of such a network induced by diabetes. A cubic region representing local skin tissue is selected as the computational domain, which in turn includes two intravascular and extravascular sub-domains. To save computational resources, the capillary network is reduced to a 1D pipeline model and embedded into the extravascular region. On the basis of the immersed boundary method (IBM) strategy, fluid and heat… More >

Osama M. AHMED¹, Mohamed A. HASSAN², Ablaa S. SALEH²

BIOCELL, Vol.44, No.1, pp. 27-29, 2020, DOI:10.32604/biocell.2020.08040

Abstract This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells (BM-MSCs) on disturbed lipid profile, heart and kidney functions, oxidative stress and antioxidant defense system in streptozotocin (STZ)-induced diabetic rats. Type 1 diabetes mellitus (T1DM) was induced in male Wistar rats by injecting 40 mg/kg body weight (b.w.) STZ dissolved in citrate buffer (pH 4.5). The diabetic rats were treated with hesperetin orally administered at dose 20 mg/kg b.w., BM-MSCs intravenously injected at a dose of 1 x 106 cells/ rat/week and their combination for 6 weeks. The diabetic rats exhibited lipid abnormalities manifested by… More >