WEI LIANG^1,2,*, ZONGWEI ZHANG^1,2, KEJU YANG^1,2,3, HONGTU HU^1,2, QIANG LUO^1,2, ANKANG YANG^1,2, LI CHANG⁴, YUANYUAN ZENG⁴

BIOCELL, Vol.47, No.6, pp. 1253-1263, 2023, DOI:10.32604/biocell.2023.027373

Abstract Background: Diabetic nephropathy (DN) is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide. Diagnostic biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of DN. Kidney biopsy is the gold standard for diagnosing DN; however, its invasive character is its primary limitation. The machine learning approach provides a non-invasive and specific criterion for diagnosing DN, although traditional machine learning algorithms need to be improved to enhance diagnostic performance. Methods: We applied high-throughput RNA sequencing to obtain the genes related to DN tubular… More >

S. Deva Kumar, S. Venkatramaphanikumar^*, K. Venkata Krishna Kishore

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 1013-1032, 2023, DOI:10.32604/iasc.2023.038165

Abstract Type 2 diabetes patients often suffer from microvascular complications of diabetes. These complications, in turn, often lead to vision impairment. Diabetic Retinopathy (DR) detection in its early stage can rescue people from long-term complications that could lead to permanent blindness. In this study, we propose a complex deep convolutional neural network architecture with an inception module for automated diagnosis of DR. The proposed novel Hybrid Inception U-Net (HIUNET) comprises various inception modules connected in the U-Net fashion using activation maximization and filter map to produce the image mask. First, inception blocks were used to enlarge the model’s width by substituting… More >

V. Banupriya^1,*, S. Anusuya²

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 5597-5613, 2023, DOI:10.32604/cmc.2023.038696

Abstract In the modern world, one of the most severe eye infections brought on by diabetes is known as diabetic retinopathy (DR), which will result in retinal damage, and, thus, lead to blindness. Diabetic retinopathy (DR) can be well treated with early diagnosis. Retinal fundus images of humans are used to screen for lesions in the retina. However, detecting DR in the early stages is challenging due to the minimal symptoms. Furthermore, the occurrence of diseases linked to vascular anomalies brought on by DR aids in diagnosing the condition. Nevertheless, the resources required for manually identifying the lesions are high. Similarly,… More >

Sultan Mesfer Aldossary^*

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3387-3404, 2023, DOI:10.32604/iasc.2023.035249

Abstract With the emergence of cloud technologies, the services of healthcare systems have grown. Simultaneously, machine learning systems have become important tools for developing matured and decision-making computer applications. Both cloud computing and machine learning technologies have contributed significantly to the success of healthcare services. However, in some areas, these technologies are needed to provide and decide the next course of action for patients suffering from diabetic kidney disease (DKD) while ensuring privacy preservation of the medical data. To address the cloud data privacy problem, we proposed a DKD prediction module in a framework using cloud computing services and a data… More >

Mohammad Yamin^1,*, Sarah Basahel¹, Saleh Bajaba², Mona Abusurrah³, E. Laxmi Lydia⁴

Computer Systems Science and Engineering, Vol.46, No.2, pp. 1901-1916, 2023, DOI:10.32604/csse.2023.036455

Abstract Recently, there has been a considerable rise in the number of diabetic patients suffering from diabetic retinopathy (DR). DR is one of the most chronic diseases and makes the key cause of vision loss in middle-aged people in the developed world. Initial detection of DR becomes necessary for decreasing the disease severity by making use of retinal fundus images. This article introduces a Deep Learning Enabled Large Scale Healthcare Decision Making for Diabetic Retinopathy (DLLSHDM-DR) on Retinal Fundus Images. The proposed DLLSHDM-DR technique intends to assist physicians with the DR decision-making method. In the DLLSHDM-DR technique, image preprocessing is initially… More >

Swagata Boruah¹, Archit Dehloo¹, Prajul Gupta², Manas Ranjan Prusty^3,*, A. Balasundaram³

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 927-942, 2023, DOI:10.32604/cmc.2023.035143

Abstract Diabetic Retinopathy (DR) is a serious hazard that can result in irreversible blindness if not addressed in a timely manner. Hence, numerous techniques have been proposed for the accurate and timely detection of this disease. Out of these, Deep Learning (DL) and Computer Vision (CV) methods for multiclass categorization of color fundus images diagnosed with Diabetic Retinopathy have sparked considerable attention. In this paper, we attempt to develop an extended ResNet152V2 architecture-based Deep Learning model, named ResNet2.0 to aid the timely detection of DR. The APTOS-2019 dataset was used to train the model. This consists of 3662 fundus images belonging… More >

Abdullah O. Alamoudi^1,*, Sarah Mohammed Allabun²

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 2265-2281, 2023, DOI:10.32604/cmc.2023.032429

Abstract Biomedical image processing is finding useful in healthcare sector for the investigation, enhancement, and display of images gathered by distinct imaging technologies. Diabetic retinopathy (DR) is an illness caused by diabetes complications and leads to irreversible injury to the retina blood vessels. Retinal vessel segmentation techniques are a basic element of automated retinal disease screening system. In this view, this study presents a novel blood vessel segmentation with deep learning based classification (BVS-DLC) model for DR diagnosis using retinal fundus images. The proposed BVS-DLC model involves different stages of operations such as preprocessing, segmentation, feature extraction, and classification. Primarily, the… More >

Sesikala Bapatla¹, J. Harikiran^2,*

Computer Systems Science and Engineering, Vol.46, No.1, pp. 597-617, 2023, DOI:10.32604/csse.2023.034998

Abstract Diabetes problems can lead to an eye disease called Diabetic Retinopathy (DR), which permanently damages the blood vessels in the retina. If not treated early, DR becomes a significant reason for blindness. To identify the DR and determine the stages, medical tests are very labor-intensive, expensive, and time-consuming. To address the issue, a hybrid deep and machine learning technique-based autonomous diagnostic system is provided in this paper. Our proposal is based on lesion segmentation of the fundus images based on the LuNet network. Then a Refined Attention Pyramid Network (RAPNet) is used for extracting global and local features. To increase… More >

Kittipol Wisaeng^*

Computer Systems Science and Engineering, Vol.46, No.1, pp. 1039-1058, 2023, DOI:10.32604/csse.2023.034901

Abstract One of the earliest indications of diabetes consequence is Diabetic Retinopathy (DR), the main contributor to blindness worldwide. Recent studies have proposed that Exudates (EXs) are the hallmark of DR severity. The present study aims to accurately and automatically detect EXs that are difficult to detect in retinal images in the early stages. An improved Fusion of Histogram–Based Fuzzy C–Means Clustering (FHBFCM) by a New Weight Assignment Scheme (NWAS) and a set of four selected features from stages of pre-processing to evolve the detection method is proposed. The features of DR train the optimal parameter of FHBFCM for detecting EXs… More >

M. P. Thiruvenkatasuresh^1,*, Surbhi Bhatia², Shakila Basheer³, Pankaj Dadheech⁴

Intelligent Automation & Soft Computing, Vol.36, No.2, pp. 1767-1782, 2023, DOI:10.32604/iasc.2023.033711

Abstract The study aimed to apply to Machine Learning (ML) researchers working in image processing and biomedical analysis who play an extensive role in comprehending and performing on complex medical data, eventually improving patient care. Developing a novel ML algorithm specific to Diabetic Retinopathy (DR) is a challenge and need of the hour. Biomedical images include several challenges, including relevant feature selection, class variations, and robust classification. Although the current research in DR has yielded favourable results, several research issues need to be explored. There is a requirement to look at novel pre-processing methods to discard irrelevant features, balance the obtained… More >