YANG CAO^1,#, YINING LIU^1,#, YANG YU¹, XIAOFEI GUO¹, XIUXIU WANG¹, WENYA MA¹, HANJING LI², ZHONGYU REN², XINLU GAO², SIJIA LI², HAOYU JI², HONGYANG CHEN², HONG YAN², YANAN TIAN², XIN WANG², BENZHI CAI^1,2,*

BIOCELL, Vol.47, No.6, pp. 1407-1416, 2023, DOI:10.32604/biocell.2023.029080

Abstract Background: Cardiomyocytes derived from human embryonic stem cells (hESCs) are regulated by complex and stringent gene networks during differentiation. Long non-coding RNAs (lncRNAs) exert critical epigenetic regulatory functions in multiple differentiation processes. However, the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated. Here, we identified the key roles of ZFAS1 (lncRNA zinc finger antisense 1) in the differentiation of cardiomyocytes from hESCs. Methods: A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method, and the number of beating hESCs-derived cardiomyocytes was calculated. Gene expression was analyzed by… More >

Muhammad Aadil Siddiqui^1,*, M. H. Md Khir¹, Zaka Ullah², Muath Al Hasan², Abdul Saboor³, Saeed Ahmed Magsi¹

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 2859-2871, 2023, DOI:10.32604/cmc.2023.034164

Abstract One of the most pressing concerns for the consumer market is the detection of adulteration in meat products due to their preciousness. The rapid and accurate identification mechanism for lard adulteration in meat products is highly necessary, for developing a mechanism trusted by consumers and that can be used to make a definitive diagnosis. Fourier Transform Infrared Spectroscopy (FTIR) is used in this work to identify lard adulteration in cow, lamb, and chicken samples. A simplified extraction method was implied to obtain the lipids from pure and adulterated meat. Adulterated samples were obtained by mixing lard with chicken, lamb, and… More >

JESSICA CRISTINA MARÍN-LLERA^*, CARLOS AMAURY JIMÉNEZ-CÁRDENAS, JESÚS CHIMAL-MONROY^*

BIOCELL, Vol.47, No.3, pp. 465-471, 2023, DOI:10.32604/biocell.2023.024625

Abstract The molecular cascade underlying tendon formation starts when progenitor cells begin to express the Scleraxis (Scx) gene. Scx knockout mice develop some but not all tendons, suggesting that additional factors are necessary for tendon commitment, maintenance, and differentiation. Other transcription factors, such as Mohawk (Mkx) or early growth response (Egr), maintain Scx expression and extracellular matrix formation during fibrillogenesis. The inhibition of wingless and int-related protein signaling is necessary and sufficient to induce the expression of Scx. Once the commitment of tenogenic lineage occurs, transforming growth factor-beta (TGFβ) induces the Scx gene expression, becoming involved in the maintenance of tendon… More >

YUNG-FU CHANG^1,2,3,*

BIOCELL, Vol.47, No.2, pp. 283-287, 2023, DOI:10.32604/biocell.2023.025743

Abstract Areca nut is used worldwide as a hallucinogenic addicting drug along the tropical belt. Arecoline, a toxic compound, is the most important alkaloid in areca nuts. The adverse effects of oral uptake and chewing of areca nut are well known. For example, the possibility of cancer caused by chewing areca nuts is widely discussed. Chewing areca nut has other adverse effects on other organs, including abnormal cell differentiation, oral cancer, and several other diseases. The use of areca nut is also associated with low birthweight. Skeletal musculature is the largest organ in the body and is attached to the bones.… More >

Lin Yuan¹, Jingcheng Zhang^2,*, Quan Deng², Yingying Dong³, Haolin Wang², Xiankun Du²

Phyton-International Journal of Experimental Botany, Vol.92, No.2, pp. 611-628, 2023, DOI:10.32604/phyton.2022.023662

Abstract Hyperspectral imaging technique is known as a promising non-destructive way for detecting plants diseases and pests. In most previous studies, the utilization of the whole spectrum or a large number of bands as well as the complexity of model structure severely hampers the application of the technique in practice. If a detection system can be established with a few bands and a relatively simple logic, it would be of great significance for application. This study established a method for identifying and discriminating three commonly occurring diseases and pests of wheat, i.e., powdery mildew, yellow rust and aphid with a few… More >

SUKUMARAN ANIL^1,2,*, RAMYA RAMADOSS³, NEBU G. THOMAS⁴, JASMIN M. GEORGE⁴, VISHNUPRIYA K. SWEETY⁴

BIOCELL, Vol.47, No.1, pp. 71-80, 2023, DOI:10.32604/biocell.2023.024334

Abstract Exfoliated deciduous or an extracted healthy adult tooth can be used to harvest, process, and cryogenically preserve dental pulp stem cells. Future stem cell-based regenerative medicine methods could benefit significantly from these mesenchymal stem cells. Teeth serve as a substantial source of mesenchymal stem cells, otherwise disposed of as medical waste. Care should be taken to store this treasure trove of stem cells. Collective responsibility of patients, dentists, and physicians is necessary to ensure that this valuable resource is not wasted and that every possible dental pulp stem cell is available for use in the future. The dental pulp stem… More >

NINGYU LI^1,2,#, XIAOFANG CHEN^2,#,§, SUXIA GENG², PEILONG LAI², LISI HUANG², MINMING LI², XIN HUANG², CHENGXIN DENG², YULIAN WANG², JIANYU WENG², XIN DU^1,2,*

BIOCELL, Vol.47, No.1, pp. 133-141, 2023, DOI:10.32604/biocell.2022.022021

Abstract The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. In this study, exosomes from bone marrow plasma were successfully extracted and identified. Assessment of miR-103-3p expression in exosomes isolated from BM in 34 MDS patients and 10 controls revealed its 0.52-fold downregulation in patients with MDS compared with controls (NOR) and was downregulated 0.55-fold in MDS-MSCs compared with NOR-MSCs. Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition… More >

Linxue Shang^1,2,3,#, Dandan Ma^4,#, Sidan Hong^1,2,3,#, Yu Zhao^1,2,3,#, Guozhe Zhang^1,2,3,#, Qingqing Ma^1,2,3, Qun Wang^1,2,3,*, Cuihua Gu^1,2,3,*

Phyton-International Journal of Experimental Botany, Vol.91, No.12, pp. 2607-2617, 2022, DOI:10.32604/phyton.2022.022485

Abstract Flower bud differentiation is a key component of plant blooming biology and understanding how it works is vital for flowering regulation and plant genetic breeding, increasing the number and quality of flowering. Red soil is the most widely covered soil type in the world, and it is also the most suitable soil type for crape myrtle planting. The flower buds of crape myrtle (Lagerstroemia indica) planted in red soil were employed as experimental materials in this study, and the distinct periods of differentiation were identified using stereomicroscopy and paraffin sectioning. We optimized the steps of dehydration, transparency, embedding, sectioning and… More >

MONICA SAVIO, VALENTINA MINOIA, PAOLA FULGHIERI, LUCIA ANNA STIVALA^*, VIRGINIE SOTTILE^*

BIOCELL, Vol.46, No.12, pp. 2525-2530, 2022, DOI:10.32604/biocell.2022.022924

Abstract The nutraceutical resveratrol is associated with a range of biological effects, from antibiotic to anti-inflammatory activities. One major axis of research has sought to harness its anti-tumour potential, with promising preclinical results and early clinical trials. A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell research. It is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in vivo. Here we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds. More >

Jun Zhao¹, Shuguo Gao¹, Yunpeng Liu^2,3, Quan Wang^2,*, Ziqiang Xu², Yuan Tian¹, Lu Sun¹

Energy Engineering, Vol.119, No.5, pp. 1811-1828, 2022, DOI:10.32604/ee.2022.020490

Abstract Aiming at the problem of abnormal data generated by a power transformer on-line monitoring system due to the influences of transformer operation state change, external environmental interference, communication interruption, and other factors, a method of anomaly recognition and differentiation for monitoring data was proposed. Firstly, the empirical wavelet transform (EWT) and the autoregressive integrated moving average (ARIMA) model were used for time series modelling of monitoring data to obtain the residual sequence reflecting the anomaly monitoring data value, and then the isolation forest algorithm was used to identify the abnormal information, and the monitoring sequence was segmented according to the… More >