Li RS¹, YJ Tao², FJ Liu², X Hu², QL Xu², KY Li²

Phyton-International Journal of Experimental Botany, Vol.85, pp. 87-93, 2016, DOI:10.32604/phyton.2016.85.087

Abstract The grass pea (Lathyrus sativus L.) and flatpod peavine (Lathyrus cicera L.) are the most economically important and widely cultivated Lathyrus species. However, their utilization is limited due to the presence of their endogenous toxin β-N-oxalyl-L-α, β-diaminopropionic acid (β-ODAP). Thus, a β-ODAP free variety should be developed through some plant breeding technique like either mutational breeding or genetic-manipulation. In this circumstance, the plant regeneration of Lathyrus species becomes a bottleneck. In the present study, an efficient system for in vitro regeneration of L. sativus with high β-ODAP levels, and L. cicera with low β-ODAP levels, was developed from different explants… More >

Liang Ding^1,*, Lunjie Li¹, Jianghong Han¹, Yuqi Fan^2,*, Donghui Hu¹

CMC-Computers, Materials & Continua, Vol.61, No.3, pp. 1285-1304, 2019, DOI:10.32604/cmc.2019.06160

Abstract Botnets often use domain generation algorithms (DGA) to connect to a command and control (C2) server, which enables the compromised hosts connect to the C2 server for accessing many domains. The detection of DGA domains is critical for blocking the C2 server, and for identifying the compromised hosts as well. However, the detection is difficult, because some DGA domain names look normal. Much of the previous work based on statistical analysis of machine learning relies on manual features and contextual information, which causes long response time and cannot be used for real-time detection. In addition, when a new family of… More >

Yongliang Wang¹, Dana N LeVine², Xuefeng Wang^1,3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 105-105, 2019, DOI:10.32604/mcb.2019.07872

Abstract Platelets are important blood cells mediating hemostasis and thrombosis. Integrin tension plays a critical role in most platelet functions, such as adhesion, activation, aggregation and contraction. Visualizing and measuring single platelet forces are desired in both research and diagnosis of platelet functions. Here we developed integrative tension sensor (ITS) which converts integrin molecular tension to fluorescent signal, therefore enabling cellular force mapping directly by fluorescence imaging. With the ITS, we mapped integrin-transmitted platelet force at 0.4 µm resolution during platelet adhesion and contraction. We found that platelet force distribution has strong polarization which is sensitive to treatment with anti-platelet drugs,… More >

Longwei Liu¹, Praopim Limsakul¹, Shaoying (Kathy) Lu¹, Peter Yingxiao Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 82-82, 2019, DOI:10.32604/mcb.2019.07360

Abstract Genetically-encoded biosensors based on Fluorescence Resonance Energy Transfer (FRET biosensors) have been widely used to dynamically track the activity of Protein Tyrosine Kinases (PTKs) in living cells because of their sensitive ratiometric fluorescence readout, high spatiotemporal resolution. However, the limitation in sensitivity, specificity, and dynamic range of these biosensors have hindered their broader applications, and there was a lack of efficient ways to optimize FRET biosensors. Here we established a rapid, systematic and universal approach for FRET biosensor optimization through directed evolution which involves generating genetic diversity and screening for protein variants with desired properties at the same time and… More >

Takeo Matsumoto^1,*, Chizuru Hirooka¹, Yong Fan¹, Junfeng Wang¹, Naoki Mori¹, Eijiro Maeda¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 81-81, 2019, DOI:10.32604/mcb.2019.07102

Abstract Aortic wall thickens in response to hypertension. Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level. In case of the longitudinal direction, however, there are few studies suggesting the constancy of the stress. Such anisotropic response may be attributable to the circumferential alignment of the smooth muscle cells (SMCs) in the wall [1]. However, to the authors’ knowledge, there are no study discussing the underlying mechanism of the anisotropic response. It has been reported that mechanical deformation of the nuclei causes transcription upregulation [2]. This might suggest that… More >

Lili Dong¹, Yang Song^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 78-78, 2019, DOI:10.32604/mcb.2019.07130

Abstract It has been widely recognized that stem cells possess the potential of osteogenic differentiation, which greatly contribute to bone repair. Recently, accumulating evidences have indicated that mechanical cues are required for bone repair ^[1,2]. However, how local and recruited stem cells in the bone architecture receive the mechanical signals is poorly understood ^[3,4]. The purpose of this study is to demonstrate that macrophages potentially transduce the mechanical signals for stem cell osteogenic lineage. This demonstration has been carried out through a co-culture system to investigate the effect of macrophages which subjected to cyclic stretch on the osteogenic potential of bone… More >

R. Jegadeeshwaran¹, V. Sugumaran², K.P. Soman³

Structural Durability & Health Monitoring, Vol.10, No.1, pp. 81-97, 2014, DOI:10.3970/sdhm.2014.010.081

Abstract In automobile, brake system is an essential part responsible for control of the vehicle. Vibration signals of a rotating machine contain the dynamic information about its health condition. Many research papers have reported the suitability of vibration signals for fault diagnosis applications. Many of them are based on (Fast Fourier Transform) FFT, which have their own drawback with nonstationary signals. Hence, there is a need for development of new methodologies to infer diagnostic information from such non stationary signals. This paper uses vibration signals acquired from a hydraulic brake system under good and simulated faulty conditions for the purpose of… More >

Akhil Muralidharan^1,2, V. Sugumaran¹, K.P Soman³, M. Amarnath⁴

Structural Durability & Health Monitoring, Vol.10, No.1, pp. 55-80, 2014, DOI:10.3970/sdhm.2014.010.055

Abstract Gears are machine elements that transmit motion by means of successively engaging teeth. In purely scientific terms, gears are used to transmit motion. A faulty gear is a matter of serious concern as it affects the functionality of a machine to a great extent. Thus it is essential to diagnose the faults at an initial stage so as to reduce the losses that might be incurred. This necessitates the need for continuous monitoring of the gears. The vibrations produced by gears from good and simulated faulty conditions can be effectively used to detect the faults in these gears. The introduction… More >

Leandro Fleck Fadel Miguel¹, Letícia Fleck Fadel Miguel²

Structural Durability & Health Monitoring, Vol.8, No.3, pp. 249-270, 2012, DOI:10.32604/sdhm.2012.008.249

Abstract Model updating may be defined as an adjustment on the FE model through modal parameters experimentally obtained, in order to better represent its dynamic behavior. From this definition, structural health monitoring (SHM) methods can be considered closely related with these procedures, because it refers to the implementation of in situ non-destructive sensing and analysis of the dynamic system characteristics, which aims to detect changes that could indicate damage. Within this context, the present paper evaluates an iterative model updating approach when it is subjected to experimental vibration data. In addition, after getting the experimental adjusted model, a numerical damage detection… More >

Peter L. Bishay¹, Satya N. Atluri¹

CMC-Computers, Materials & Continua, Vol.33, No.1, pp. 19-62, 2013, DOI:10.3970/cmc.2013.033.019

Abstract In this paper, 2D and 3D Multiphysics Voronoi Cells (MVCs) are developed, for the Direct Mesoscale Numerical Simulation (DMNS) of the switching phenomena in ferroelectric polycrystalline materials. These arbitrarily shaped MVCs (arbitrary polygons in 2D, and arbitrary polyhedrons in 3D with each face being an arbitrary polygon) are developed, based on assuming radial basis functions to represent the internal primal variables (mechanical displacements and electric potential), and assuming linear functions to represent the primal variables on the element boundaries. For the 3D case, the linear functions used to represent the primal variables on each of the polygonal surfaces of the… More >