YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056

Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

JIYU WANG^1,2, HUIXIA LI^1,2, DEYUAN ZHOU^1,2, LIHONG BAI^1,2, KEJING TANG^1,2,3,*

BIOCELL, Vol.48, No.4, pp. 623-637, 2024, DOI:10.32604/biocell.2024.030420

Abstract Background: For patients with lung cancer, timely identification of new lung lesions as infectious or non-infectious, and accurate identification of pathogens is very important in improving OS of patients. As a new auxiliary examination, metagenomic next-generation sequencing (mNGS) is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases, compared with conventional microbial tests (CMTs). We designed this study to find out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavage fluid (BALF). Materials and Methods: This study was a real-world retrospective review based on electronic medical… More >

Muhammad Umar Nasir¹, Omar Kassem Khalil², Karamath Ateeq³, Bassam SaleemAllah Almogadwy⁴, Muhammad Adnan Khan⁵, Muhammad Hasnain Azam⁶, Khan Muhammad Adnan^7,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3303-3321, 2024, DOI:10.32604/cmc.2024.048035

Abstract Cardiotocography measures the fetal heart rate in the fetus during pregnancy to ensure physical health because cardiotocography gives data about fetal heart rate and uterine shrinkages which is very beneficial to detect whether the fetus is normal or suspect or pathologic. Various cardiotocography measures infer wrongly and give wrong predictions because of human error. The traditional way of reading the cardiotocography measures is the time taken and belongs to numerous human errors as well. Fetal condition is very important to measure at numerous stages and give proper medications to the fetus for its well-being. In the current period Machine learning… More >

Mahmood A. Mahmood^1,2,*, Khalaf Alsalem¹

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3431-3448, 2024, DOI:10.32604/cmc.2024.047604

Abstract Olive trees are susceptible to a variety of diseases that can cause significant crop damage and economic losses. Early detection of these diseases is essential for effective management. We propose a novel transformed wavelet, feature-fused, pre-trained deep learning model for detecting olive leaf diseases. The proposed model combines wavelet transforms with pre-trained deep-learning models to extract discriminative features from olive leaf images. The model has four main phases: preprocessing using data augmentation, three-level wavelet transformation, learning using pre-trained deep learning models, and a fused deep learning model. In the preprocessing phase, the image dataset is augmented using techniques such as… More >

Bhawna Goyal¹, Ayush Dogra², Dawa Chyophel Lepcha¹, Rajesh Singh³, Hemant Sharma⁴, Ahmed Alkhayyat⁵, Manob Jyoti Saikia^6,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 4317-4342, 2024, DOI:10.32604/cmc.2024.047256

Abstract Multimodal medical image fusion has attained immense popularity in recent years due to its robust technology for clinical diagnosis. It fuses multiple images into a single image to improve the quality of images by retaining significant information and aiding diagnostic practitioners in diagnosing and treating many diseases. However, recent image fusion techniques have encountered several challenges, including fusion artifacts, algorithm complexity, and high computing costs. To solve these problems, this study presents a novel medical image fusion strategy by combining the benefits of pixel significance with edge-preserving processing to achieve the best fusion performance. First, the method employs a cross-bilateral… More >

Sipawath Khamplod^1,2, Yodying Kaolawanich^1,2, Khemajira Karaketklang³, Nithima Ratanasit^1,2,*

Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631

Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause mortality. Univariable and multivariable analyses… More > Graphic Abstract

Fu Guan^1,*, Matthias Gass², Florian Berger², Heiko Schneider¹, Firat Duru^1,3, Thomas Wolber^1,3,*

Congenital Heart Disease, Vol.19, No.1, pp. 85-92, 2024, DOI:10.32604/chd.2024.047266

Abstract Aims: Although the application of ultrasound-guided vascular puncture and Z-stitch hemostasis to manage femoral access has been widely utilized, there is limited data on this combined application in adult congenital heart disease (ACHD) patients undergoing electrophysiological (EP) procedures. We sought to evaluate the safety and efficacy of ultrasound-guided puncture and postprocedural Z-stitch hemostasis for ACHD patients undergoing EP procedures. Methods and Results: The population of ACHD patients undergoing transfemoral EP procedures at the University of Zurich Heart Center between January 2019 and December 2022 was observed and analyzed. During the study period, femoral access (left/right, arterial/venous) was performed under real-time… More >

Albert Osom¹, Krysta S. Barton², Katie Sexton^3,4, Lyndia Brumback¹, Joyce P. Yi-Frazier⁴, Abby R. Rosenberg^5,6, Ruth Engelberg⁷, Jill M. Steiner^8,*

Congenital Heart Disease, Vol.19, No.1, pp. 33-48, 2024, DOI:10.32604/chd.2024.046656

Abstract Social determinants of health (SDOH) affect quality of life. We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease (ACHD). Secondary analysis of data from two complementary studies: a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August 2021. Resilience was assessed through CD-RISC10 score (range 0–40, higher scores reflect greater self-perceived resilience) and interview responses. Sociodemographic and SDOH (education, employment, living situation, monetary stability, financial dependency, area deprivation index) data were collected by healthcare record review and self-report. We used linear regression with robust standard errors to analyze survey data and… More > Graphic Abstract

Michael A. Rebolledo^1,*, Jane S. Yao², Jason N. Johnson¹, Umar S. Boston³, Benjamin R. Waller III¹

Congenital Heart Disease, Vol.19, No.1, pp. 65-68, 2024, DOI:10.32604/chd.2024.046638

Abstract We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the mid-1960s. We review the clinical and imaging data that support our conclusion. He had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and oxygen. Our case may represent one example of the experimental surgical work done prior to Dr. Adibe Jatene’s description of the first successful arterial switch performed in 1975. More >

Molly Clarke^1,*, Karin Hamann², Nancy Klein², Laura Olivieri³, Yue-Hin Loke²

Congenital Heart Disease, Vol.19, No.1, pp. 5-17, 2024, DOI:10.32604/chd.2024.046328

Abstract Background: Patients with congenital heart disease (CHD) will transition to lifelong adult congenital cardiac care. However, their structural heart disease is challenging to convey via two-dimensional drawings. This study utilized a tele-educational environment, with personalized three-dimensional (3D) modeling and health Details (3D + Details = “4D”), to improve actual and perceived knowledge, both important components of transition readiness in CHD patients. Methods: Participants aged ≥13 years with a history of CHD and cardiac magnetic resonance imaging (MRI) studies were eligible. Cardiac MRI datasets were then used to segment and create 3D heart models (using Mimics, Materialize Inc.). Participants first completed… More >