Sung-Eun Kim¹, Shin Hyung Rhee²

CMES-Computer Modeling in Engineering & Sciences, Vol.62, No.3, pp. 291-310, 2010, DOI:10.3970/cmes.2010.062.291

Abstract Turbulent flow past a finite wing has been computed to assess the fidelity of modern computational fluid dynamics in predicting tip vortex flows. The efficacy of a feature-adaptive local mesh refinement to resolve the steep gradients in the flow field near the tip vortex is demonstrated. The impact of turbulence modeling is evaluated using several popular eddy viscosity models and a Reynolds stress transport model. The results indicate that the combination of a computational mesh with an adequate resolution, high-order spatial discretization scheme along with the use of advanced turbulence models can predict tip vortex flows with acceptable accuracy. More >

S S Panda¹, C S Manohar^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.28, No.3, pp. 161-184, 2008, DOI:10.3970/cmes.2008.028.161

Abstract The problem of reliability analysis of randomly parametered, linear (or) nonlinear, structures subjected to static and (or) dynamic loads is considered. A deterministic finite element model for the structure to analyze sample realization of the structure is assumed to be available. The reliability analysis is carried out within the framework of response surface methods which involves the construction of surrogate models for performance functions to be employed in reliability calculations. This construction, in the present study, has involved combining space filling optimal Latin hypercube sampling, kriging models and methods from data-based asymptotic extreme value modeling of sequence of random variables.… More >

G. Frulla¹, P. Gili¹, M. Visone², V. D’Oriano^2,3, M. Lappa⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.11, No.3, pp. 257-277, 2015, DOI:10.3970/fdmp.2015.011.257

Abstract A practical engineering approach to the design of a 60 kW wind generator with improved performances is presented. The proposed approach relies on the use of a specific, "ad hoc'' developed software, OPTIWR (Optimization Software), expressly conceived to define an "optimum'' rotor configuration in the framework of the blade-element-momentum theory. Starting from an initial input geometric configuration (corresponding to an already existing 50 kW turbine) and for given values of the wind velocity V_wind and of the advance ratio X = V_wind/ΩR (where Ω is the blade rotational speed and R is the propeller radius), this software is used to… More >

Marcello Lappa¹

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.2, pp. 141-152, 2006, DOI:10.3970/fdmp.2006.002.141

Abstract Numerical simulations and computer-graphics animation can be used as useful tools to discern the physicochemical environmental factors affecting the surface kinetics of growing biological tissues as well as their relative importance in determining growth. A mathematical formalism for such kinetics is proposed through parametric investigation and validated through focused comparison with experimental results. The study relies on the application of a CFD moving boundary (Volume of Fluid) method specially conceived for the simulation of these problems. In the second part of the analysis the case of two samples hydrodynamically interacting in a rotating bioreactor is considered. The interplay between two… More >

Milica Radisic^1,2, Gordana Vunjak-Novakovic³

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.1, pp. 1-16, 2006, DOI:10.3970/fdmp.2006.002.001

Abstract To engineer cardiac tissue in vitro with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found in vivo. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply. More >

B. Obradovic¹, M. Radisic², G. Vunjak-Novakovic³

FDMP-Fluid Dynamics & Materials Processing, Vol.3, No.3, pp. 189-202, 2007, DOI:10.3970/fdmp.2007.003.189

Abstract Efficient transport of oxygen is one of the main requirements in tissue engineering systems in order to avoid cell death in the inner tissue regions and support uniform tissue regeneration. In this paper, we review approaches to design of tissue engineering systems with adequate oxygen delivery for cultivation of cartilage and myocardium, two distinctly different tissue types with respect to the tissue structure and oxygen requirements. Mathematical modeling was used to support experimental results and predict oxygen transport within the cultivated tissues and correlate it to the cell response and tissue properties. More >

P. Yu¹, T. S. Lee¹, Y. Zeng¹, H. T. Low²

FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.3, pp. 235-246, 2005, DOI:10.3970/fdmp.2005.001.235

Abstract A numerical model is developed for the investigation of flow field and mass transport in a micro-bioreactor, of working volume below 5 ml, in which medium mixing is generated by a magnetic stirrer-rod rotating on the bottom. The flow-field results show that a recirculation region exists above the stirrer rod and rotates with it; the related fluid mixing is characterized by a circulation coefficient of up to 0.2 which is about five times smaller than that of a one-litre stirred-tank bioreactor. The oxygen transfer coefficient is less than 5 h^-1 which is two orders smaller than that of a 10-litre… More >

L.L. Zhu^1,2,3, X.J. Zheng^1,2

CMC-Computers, Materials & Continua, Vol.18, No.3, pp. 301-320, 2010, DOI:10.3970/cmc.2010.018.301

Abstract The phonon properties of spatially confined nanofilms under the preexisting stress fields are investigated theoretically by accounting for the confinement effects and acoustoelastic effects. Due to the spatial confinement in low-dimensional structures, the phonon dispersion relations, phonon group velocities as well as the phonon density of states are of significant difference with the ones in bulk structures. Here, the continuum elasticity theory is made use of to determine the phonon dispersion relations of shear modes (SH), dilatational modes (SA) and the flexural modes (AS), thus to analyze the contribution of stress fields on the phonon performance of confined nanofilms. Our… More >