Fankun Meng^1,2,3, Yuyang Liu^1,2,*, Xiaohua Liu⁴, Chenlong Duan^1,2, Yuhui Zhou^1,2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.1, 2026, DOI:10.32604/fdmp.2026.075865 - 06 February 2026

Abstract Carbonate gas reservoirs are often characterized by strong heterogeneity, complex inter-well connectivity, extensive edge or bottom water, and unbalanced production, challenges that are also common in many heterogeneous gas reservoirs with intricate storage and flow behavior. To address these issues within a unified, data-driven framework, this study develops a multi-block material balance model that accounts for inter-block flow and aquifer influx, and is applicable to a wide range of reservoir types. The model incorporates inter-well and well-group conductive connectivity together with pseudo–steady-state aquifer support. The governing equations are solved using a Newton–Raphson scheme, while particle More > Graphic Abstract

Ziying Huang¹, Ruikang Ma¹, Anning Li², Yufei Cheng¹, Xiaolin Lin², Mengzhi Li³, Yu Zhang², Liping Shi¹, Linlin Dong^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2025.074419 - 30 January 2026

Abstract Epimedium is commonly used to treat bone injury and kidney disease, with prenylated flavonol glycosides (PFGs) as its active ingredients. It has attracted much attention due to prominent healthcare and therapeutic effects, but faces problems of adulteration with closely related species and confusion about geographical origins. In this study, multiple technical approaches were employed to identify its genetic characteristics and metabolic differences. Based on DNA barcoding, 20 batches of samples were analyzed. The genetic distances of matK, ITS and psbA-trnH within species were all smaller than those between species, and psbA-trnH along with ITS + psbA-trnH proved most effective… More >

Abdulrazzak Akroot¹, Kayser Aziz Ameen², Haitham M. Ibrahim³, Hasanain A. Abdul Wahhab^3,*, Miqdam T. Chaichan⁴

Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.073702 - 27 January 2026

Abstract Improving energy efficiency and lowering negative environmental impact through waste heat recovery (WHR) is a critical step toward sustainable cement manufacturing. This study analyzes advanced cogeneration systems for recovering waste heat from the Fallujah White Cement Plant in Iraq. The novelty of this work lies in its direct application and comparative thermodynamic analysis of three distinct cogeneration cycles—the Organic Rankine Cycle, the Single-Flash Steam Cycle, and the Dual-Pressure Steam Cycle—within the Iraqi cement industry, a context that has not been widely studied. The main objective is to evaluate and compare these models to determine the… More > Graphic Abstract

SHAOFENG XIONG^1,2, WENKAI LV³, GUOSHENG CAO⁴, LONGSHENG FU¹, WEN LIU³, MENGFAN LEI², YANNI LV^1,5,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

Douglas M. Ruden^*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072273 - 23 January 2026

Abstract Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs: the integrated stress response (ISR) and the senescence-associated secretory phenotype (SASP). These pathways act as a Yin–Yang system, balancing beneficial and detrimental outcomes across development, tissue homeostasis, and disease. On the yin (protective) side, transient ISR activation and acute SASP signaling foster adaptation, embryonic patterning, wound healing, and regeneration. On the yang (maladaptive) side, chronic ISR signaling and unresolved SASP output drive stem cell exhaustion, fibrosis, inflammation, and tumorigenesis. This duality highlights their roles as both guardians and disruptors More > Graphic Abstract

Luis Felipe HernáNdez-Ayala¹, Russel J. Reiter², Annia Galano^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.071635 - 23 January 2026

Abstract Objectives: Oxidative stress (OS) plays a pivotal role in chronic and neurodegenerative diseases, which has sparked interest in molecules that modulate redox-regulating enzymes. Melatonin and its metabolites exhibit antioxidant properties; however, their molecular mechanisms of enzymatic and transcriptional modulation remain unclear. This study aimed to investigate, through an exploratory in silico approach, the interactions of melatonin and related compounds with OS-related enzymes to generate hypotheses about their role in cellular redox control. Methods: A rational selection of antioxidant, pro-oxidant, and transcriptional targets was performed. Ligands were optimized at the DFT level (M05-2X/6-311+G(d,p)) and docked to OS… More >

Harpreet Kaur^1,*, Dhrubalochan Rana², Sowvik Bag², Paramjeet Singh³

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071209 - 19 January 2026

Abstract The prolonged and intricate history of oncological treatments has transitioned significantly since the introduction of chemotherapy. Substantial therapeutic benefits in cancer therapy have been achieved by the integration of conventional treatments with molecular biosciences and omics technologies. Human epidermal growth factor receptor, hormone receptors, and angiogenesis factors are among the established therapies in tumor reduction and managing side effects. Novel targeted therapies like KRAS G12C, Claudin-18 isoform 2 (CLDN18.2), Trophoblast cell-surface antigen 2 (TROP2), and epigenetic regulators emphasize their promise in advancing precision medicine. However, in many cases, the resistance mechanisms associated with these interventions… More > Graphic Abstract

Shail Rakesh Modi, Terrick Andey^*, George Acquaah-Mensah^*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070793 - 19 January 2026

Abstract Objectives: The current treatment options and therapeutic targets for triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer (BrCA), are limited. This study aimed to identify novel biomarkers and transcriptional regulatory networks (TRN) inherent in TNBC samples. Methods: We analyzed pan-cancer BrCA datasets from The Cancer Genome Atlas (TCGA) to compare triple-positive breast cancer (TPBC) with TNBC. TRN algorithms and virtual inference of protein-enriched regulon (VIPER) were used to identify master regulators and their target genes. Utilizing TNBC cells (MDA-MB-231 and MDA-MB-468), we validated the relationship of nuclear factor erythroid 2-like 3 (NFE2L3) and… More > Graphic Abstract

Changjun Zhou¹, Dongfang Chen¹, Chenyang Shi¹, Taiyong Li^2,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073662 - 12 January 2026

Abstract With the rapid development of smart manufacturing, intelligent safety monitoring in industrial workshops has become increasingly important. To address the challenges of complex backgrounds, target scale variation, and excessive model parameters in worker violation detection, this study proposes ADCP-YOLO, an enhanced lightweight model based on YOLOv8. Here, “ADCP” represents four key improvements: Alterable Kernel Convolution (AKConv), Dilated-Wise Residual (DWR) module, Channel Reconstruction Global Attention Mechanism (CRGAM), and Powerful-IoU loss. These components collaboratively enhance feature extraction, multi-scale perception, and localization accuracy while effectively reducing model complexity and computational cost. Experimental results show that ADCP-YOLO achieves a More >

Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >