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  • Open Access

    ARTICLE

    Dynamic Response Impact of Vehicle Braking on Simply Supported Beam Bridges with Corrugated Steel Webs Based on Vehicle-Bridge Coupled Vibration Analysis

    Yan Wang*, Siwen Li, Na Wei

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3467-3493, 2024, DOI:10.32604/cmes.2024.046454

    Abstract A novel approach for analyzing coupled vibrations between vehicles and bridges is presented, taking into account spatiotemporal effects and mechanical phenomena resulting from vehicle braking. Efficient modeling and solution of bridge vibrations induced by vehicle deceleration are realized using this method. The method’s validity and reliability are substantiated through numerical examples. A simply supported beam bridge with a corrugated steel web is taken as an example and the effects of parameters such as the initial vehicle speed, braking acceleration, braking location, and road surface roughness on the mid-span displacement and impact factor of the bridge are analyzed. The results show… More >

  • Open Access

    ARTICLE

    Optimal Shape Factor and Fictitious Radius in the MQ-RBF: Solving Ill-Posed Laplacian Problems

    Chein-Shan Liu1, Chung-Lun Kuo1, Chih-Wen Chang2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3189-3208, 2024, DOI:10.32604/cmes.2023.046002

    Abstract To solve the Laplacian problems, we adopt a meshless method with the multiquadric radial basis function (MQ-RBF) as a basis whose center is distributed inside a circle with a fictitious radius. A maximal projection technique is developed to identify the optimal shape factor and fictitious radius by minimizing a merit function. A sample function is interpolated by the MQ-RBF to provide a trial coefficient vector to compute the merit function. We can quickly determine the optimal values of the parameters within a preferred rage using the golden section search algorithm. The novel method provides the optimal values of parameters and,… More >

  • Open Access

    ARTICLE

    Study on Influencing Factors of Mental Health of Mobile Young White-Collar Workers in China

    Tao Liu1, Lin Liu1, Zeyu Chen1,*, Rong Fu2,*

    International Journal of Mental Health Promotion, Vol.26, No.2, pp. 127-138, 2024, DOI:10.32604/ijmhp.2023.045071

    Abstract Mobile young white-collar workers not only have the characteristics of mobile young people, but also have the characteristics of general white-collar workers. Under the influence of both, their mental health may be suffering from “double disadvantage”. So, based on an ecological model of the stress process, this paper tries to use the data of the questionnaire on the mental health of mobile young white-collar workers in Zhejiang Province to explore the influence of some factors in the middle workplace and residence place on the mental health of micro individuals. The results show that: (1) The working environment with high control… More >

  • Open Access

    ARTICLE

    Overexpression of RUNX1 mitigates dexamethasone-induced impairment of osteogenic differentiation and oxidative stress injury in bone marrow mesenchymal stem cells by promoting alpha-2 macroglobulin transcription

    QINGJIAN HE1, HUIXIN ZHU2,3, SHANHONG FANG4,5,*

    BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109

    Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression by kits, OD by alkaline… More >

  • Open Access

    ARTICLE

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

    HUI SUN, MASANORI KAWANO*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

    Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085

    Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in… More > Graphic Abstract

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

  • Open Access

    ARTICLE

    Human Gait Recognition for Biometrics Application Based on Deep Learning Fusion Assisted Framework

    Ch Avais Hanif1, Muhammad Ali Mughal1, Muhammad Attique Khan2,3,*, Nouf Abdullah Almujally4, Taerang Kim5, Jae-Hyuk Cha5

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 357-374, 2024, DOI:10.32604/cmc.2023.043061

    Abstract The demand for a non-contact biometric approach for candidate identification has grown over the past ten years. Based on the most important biometric application, human gait analysis is a significant research topic in computer vision. Researchers have paid a lot of attention to gait recognition, specifically the identification of people based on their walking patterns, due to its potential to correctly identify people far away. Gait recognition systems have been used in a variety of applications, including security, medical examinations, identity management, and access control. These systems require a complex combination of technical, operational, and definitional considerations. The employment of… More >

  • Open Access

    ARTICLE

    Factors Influencing Fracture Propagation in Collaborative Fracturing of Multiple Horizontal Wells

    Diguang Gong1, Junbin Chen1, Cheng Cheng2, Yuanyuan Kou2,*

    Energy Engineering, Vol.121, No.2, pp. 425-437, 2024, DOI:10.32604/ee.2023.030196

    Abstract Horizontal well-stimulation is the key to unconventional resource exploration and development. The development mode of the well plant helps increase the stimulated reservoir volume. Nevertheless, fracture interference between wells reduces the fracturing effect. Here, a 2D hydro-mechanical coupling model describing hydraulic fracture (HF) propagation is established with the extended finite element method, and the effects of several factors on HF propagation during multiple wells fracturing are analyzed. The results show that with an increase in elastic modulus, horizontal principal stress difference and injection fluid displacement, the total fracture area and the reservoir stimulation efficiency are both improved in all three… More >

  • Open Access

    ARTICLE

    Variation Characteristics of Root Traits of Different Alfalfa Cultivars under Saline-Alkaline Stress and their Relationship with Soil Environmental Factors

    Tian-Jiao Wei1, Guang Li1, Yan-Ru Cui1, Jiao Xie1, Xing-Ai Gao1, Xing Teng1, Xin-Ying Zhao1, Fa-Chun Guan1,*, Zheng-Wei Liang2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 29-43, 2024, DOI:10.32604/phyton.2023.046078

    Abstract Soil salinization is the main factor that threatens the growth and development of plants and limits the increase of yield. It is of great significance to study the key soil environmental factors affecting plant root traits to reveal the adaptation strategies of plants to saline-alkaline-stressed soil environments. In this study, the root biomass, root morphological parameters and root mineral nutrient content of two alfalfa cultivars with different sensitivities to alkaline stress were analyzed with black soil as the control group and the mixed saline-alkaline soil with a ratio of 7:3 between black soil and saline-alkaline soil as the saline-alkaline treatment… More >

  • Open Access

    REVIEW

    The IDD Transcription Factors: Their Functions in Plant Development and Environmental Response

    Jing Liu1,*, Defeng Shu1, Zilong Tan1, Mei Ma1, Huanhuan Yang1, Ning Guo1,2, Shipeng Li1, Dayong Cui1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 63-79, 2024, DOI:10.32604/phyton.2023.045940

    Abstract INDETERMINATE-DOMAIN proteins (IDDs) are a plant-specific transcription factor family characterized by a conserved ID domain with four zinc finger motifs. Previous studies have demonstrated that IDDs coordinate a diversity of physiological processes and functions in plant growth and development, including floral transition, plant architecture, seed and root development, and hormone signaling. In this review, we especially summarized the latest knowledge on the functions and working models of IDD members in Arabidopsis, rice, and maize, particularly focusing on their role in the regulatory network of biotic and abiotic environmental responses, such as gravity, temperature, water, and pathogens. Understanding these mechanisms underlying… More >

  • Open Access

    ARTICLE

    Risk Factors for Abuse in Children with Congenital Heart Disease Presenting at a Pediatric Tertiary Care Hospital

    Kristi K. Westphaln1,2,*, Karen Kay Imagawa2,3, Lorena Espinosa Smith1,4, Julia Srivastava5, Nancy A. Pike1,5

    Congenital Heart Disease, Vol.18, No.6, pp. 657-670, 2023, DOI:10.32604/chd.2023.044179

    Abstract Background: Congenital heart disease (CHD) is a chronic medical condition often diagnosed at birth and requires surgical intervention, multiple hospitalizations, and lifelong care. This can put significant stress on the family, leading to altered maternal mental health, bonding and attachment issues, and the potential for child abuse. The purpose of this study is to explore the characteristics of a sample of young children with CHD who experienced hospitalization with concurrent concern for child abuse in a free-standing pediatric tertiary care hospital. Methods: Electronic medical records were reviewed for children aged 0–5 years old who were hospitalized with concern for child… More >

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