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  • Open Access

    ARTICLE

    IQGAP3 promotes the progression of glioma as an immune and prognostic marker

    XIAOFENG GAO1,2,3,4, JUANJUAN GE3, XUZHENG GAO1,3, NA MEI1,3, YANTING SU3, SHIGANG SHAN3, WENBIN QIAN3, JIANGHENG GUAN5, ZHENWANG ZHANG1,3,*, LONG WANG2,3,4,*

    Oncology Research, Vol.32, No.4, pp. 659-678, 2024, DOI:10.32604/or.2023.046712

    Abstract Background: IQGAP3 plays a crucial role in regulating cell proliferation, division, and cytoskeletal organization. Abnormal expression of IQGAP3 has been linked to various tumors, but its function in glioma is not well understood. Methods: Various methods, including genetic differential analysis, single-cell analysis, ROC curve analysis, Cox regression, Kaplan-Meier analysis, and enrichment analysis, were employed to analyze the expression patterns, diagnostic potential, prognostic implications, and biological processes involving IQGAP3 in normal and tumor tissues. The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence. Additionally, the cBioPortal database was used to analyze copy number… More > Graphic Abstract

    IQGAP3 promotes the progression of glioma as an immune and prognostic marker

  • Open Access

    ARTICLE

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

    QIOU GU1, CHUILIN LAI1, XIAO GUAN1, JING ZHU2, TIAN ZHAN1, JIANPING ZHANG1,*

    BIOCELL, Vol.48, No.2, pp. 253-269, 2024, DOI:10.32604/biocell.2023.028336

    Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Cox regression and Least Absolute… More > Graphic Abstract

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

  • Open Access

    ARTICLE

    M2 macrophages predicted the prognosis of breast cancer by combing a novel immune cell signature and promoted cell migration and invasion of cancer cells in vitro

    QI XIA1, XING CHEN2, QINGHUA MA3, XIANXIU WEN2,*

    BIOCELL, Vol.48, No.2, pp. 217-228, 2024, DOI:10.32604/biocell.2023.027414

    Abstract Background: Breast cancer (BC) is the most common cancer and the leading cause of cancer death in women. Immune features play an important role in improving the prognosis prediction of BC. However, while previous immune signatures consisted mainly of immune genes, immune cell-based signatures have been rarely reported. Methods: In this study, we report that a novel immune cell signature is effective in improving prognostic prediction by combining M2 macrophages. We identified 17 differentially infiltrating immune cells between cancer and normal groups. Prognostic features of the four immune cells identified by LASSO COX analysis showed good performance for survival risk… More >

  • Open Access

    ARTICLE

    Low expression of fatty acid oxidation related gene ACADM indicates poor prognosis of renal clear cell carcinoma and is related to tumor immune infiltration

    JIECHUAN QIU1, TIANMIN YANG1, YANNING SUN2, KAI SUN2, YINGKUN XU3, QINGHUA XIA1,*

    Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462

    Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was assessed using a diagnostic receiver… More >

  • Open Access

    PROCEEDINGS

    Fracture Behavior of Periodic Porous Structures by Phase Field Method

    Yuxuan Ying1, Wei Huang1,*, Yu-E Ma1, Fan Peng1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-3, 2023, DOI:10.32604/icces.2023.010572

    Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static cyclic compression experiments with different liquid… More >

  • Open Access

    PROCEEDINGS

    Dynamic Compression and Energy Absorption Behaviours of a Nanofluidic Liquid Foam

    Haiqi Feng1, Wei Huang1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-2, 2023, DOI:10.32604/icces.2023.09347

    Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio [1-7]. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static cyclic compression experiments with different… More >

  • Open Access

    ARTICLE

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

    XIANGDONG SUN1,2,#, HUIJUAN WEN1,2,#, FAZHAN LI1,2, IHTISHAM BUKHARI1,2, FEIFEI REN1,2, XIA XUE1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*

    Oncology Research, Vol.32, No.2, pp. 283-296, 2024, DOI:10.32604/or.2023.044618

    Abstract Nicotinamide adenine dinucleotide (NAD+) plays an essential role in cellular metabolism, mitochondrial homeostasis, inflammation, and senescence. However, the role of NAD+-regulated genes, including coding and long non-coding genes in cancer development is poorly understood. We constructed a prediction model based on the expression level of NAD+ metabolism-related genes (NMRGs). Furthermore, we validated the expression of NMRGs in gastric cancer (GC) tissues and cell lines; additionally, β-nicotinamide mononucleotide (NMN), a precursor of NAD+, was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation, cell cycle, apoptosis, and senescence-associated secretory… More > Graphic Abstract

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

  • Open Access

    ARTICLE

    CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

    SHUANGSHUANG ZENG1,2, XI CHEN1,2, QIAOLI YI1,2, ABHIMANYU THAKUR3, HUI YANG4,*, YUANLIANG YAN1,2, SHAO LIU1,2,*

    Oncology Research, Vol.32, No.2, pp. 261-272, 2024, DOI:10.32604/or.2023.042345

    Abstract Finding biomarkers for immunotherapy is an urgent issue in cancer treatment. Cellular retinoic acid-binding protein 2 (CRABP2) is a controversial factor in the occurrence and development of human tumors. However, there is limited research on the relationship between CRABP2 and immunotherapy response. This study found that negative correlations of CRABP2 and immune checkpoint markers (PD-1, PD-L1, and CTLA-4) were observed in breast invasive carcinoma (BRCA), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD) and testicular germ cell tumors (TGCT). In particular, in SKCM patients who were treated with PD-1 inhibitors, high levels of CRABP2 predicted poor prognosis. Additionally, CRABP2 expression was… More >

  • Open Access

    ARTICLE

    Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

    JUAN SHEN1,#, WEIYU ZHANG2,3,#, QINQIN JIN2,3,#, FUYU GONG4,#, HEPING ZHANG5, HONGLIANG XU5, JIEJIE LI2,3, HUI YAO2,3, XIYA JIANG2,3, YINTING YANG2,3, LIN HONG2,3, JIE MEI2,3, YANG SONG6,*, SHUGUANG ZHOU2,3,7,*

    Oncology Research, Vol.32, No.2, pp. 339-351, 2024, DOI:10.32604/or.2023.030887

    Abstract Background: Invasive breast carcinoma (BRCA) is associated with poor prognosis and high risk of mortality. Therefore, it is critical to identify novel biomarkers for the prognostic assessment of BRCA. Methods: The expression data of polo-like kinase 1 (PLK1) in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases. PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Single sample gene set enrichment analysis (ssGSEA) was performed to evaluate immune infiltration in the BRCA microenvironment, and the random forest (RF) and support vector machine (SVM) algorithms… More >

  • Open Access

    ARTICLE

    Regulation of RNA methylation and immune infiltration patterns by m5C regulators in head and neck squamous cell carcinoma

    SHIDA HOU1,#, TIANJUN LAN2,#, YAOCHENG YANG3,#, PEISHENG LIANG1, XIN LIU4,5, JUNJIE WANG6, ZHIFENG CHEN7, RONGSHENG ZENG1,*, ZIJING HUANG8,*

    BIOCELL, Vol.47, No.12, pp. 2641-2660, 2023, DOI:10.32604/biocell.2023.043291

    Abstract Background: 5-Methylcytosine (m5C) methylation contributes to the development and progression of various malignant tumors. This study aimed to explore the potential role of m5C methylation regulators (m5CMRs) in head and neck squamous cell carcinoma (HNSCC). Methods: The transcription data of HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Subsequently, the m5C patterns in HNSCC were evaluated based on 14 m5CMRs. Then, the m5Cscore was developed to quantify m5C patterns by using principal component analysis (PCA) algorithms. Two single-cell RNA sequencing datasets and various methods were employed to assess the prognostic value… More >

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