Xingyu Zhu^1,2,#, Yongjun Wang^3,#, Shuang Chang^4,#, Yue Su², Cuixia He¹, Shuang Hu⁵, Minhui Zhu¹, Yuzhou Ding², Nuannuan Ren², Qizhi Wang², Jing Xie^1,*, Huan Zhou^1,2,*

Oncologie, Vol.23, No.4, pp. 569-588, 2021, DOI:10.32604/oncologie.2021.018869

Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function… More >

F. Castinetti, A. Barlier, F. Sebag, D. Taieb

Oncologie, Vol.21, No.2, pp. 105-111, 2019, DOI:10.3166/onco-2019-0050

Abstract Pheochromocytoma and paraganglioma are tumors leading to increased morbidity and mortality. Over the last 20 years, several major advances allowed a better characterization of these tumors, either from an imaging or from a genetic viewpoint. This is especially the case for the hereditary characteristics of these tumors, as roughly 20 new genes have been identified. This is why the initial steps of the management of a pheochromocytoma and/or a paraganglioma now require a dedicated tertiary referral center. The aim of this review is to depict the diagnostic steps of these tumors, so as to allow the clinician to determine the… More >

T. Pudlarz, N. Naoun, G. Beinse, D. Grazziotin-Soares, J.-P. Lot

Oncologie, Vol.21, No.1, pp. 53-68, 2019, DOI:10.3166/onco-2019-0036

Abstract In this special issue of Oncology, we have summarized the most relevant topics that were presented at the American Association for Cancer Research (AACR) meeting. Our purpose here is to give the readers a concise report of the presentations that warrant particular attention. This year 2019 in Atlanta, the AACR Annual Meeting program covered the latest discoveries across the spectrum of cancer research — from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy — and highlights the work of the best minds in research and medicine from institutions all over the world. It… More >

KAVITHA GOVARTHANAN^1,*, PIYUSH KUMAR GUPTA², BINITA ZIPPORAHE¹, REKHA GAHTORI³, SOUMYA PANDIT², RAM PRASAD^4,*

BIOCELL, Vol.45, No.3, pp. 501-515, 2021, DOI:10.32604/biocell.2021.014441

Abstract Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined function. Tissue-specific stem cells are compartmentalized in a niche, which keeps the stem cells under quiescent condition. Thus, understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human applications. Given the developmental aspects of the cell, the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the cell. The stable inheritance of the… More >

Andrew D. Spearman

Congenital Heart Disease, Vol.12, No.6, pp. 828-833, 2017, DOI:10.1111/chd.12543

Abstract A genetic basis of congenital heart disease (CHD) has been known for decades. In addition to the sequence of the genome, the contribution of epigenetics to pediatric cardiology is increasingly recognized. Multiple epigenetic mechanisms, including DNA methylation, histone modification, and RNA-based regulation, are known mediators of cardiovascular disease, including both development and progression of CHD and its sequelae. Basic understanding of the concepts of epigenetics will be essential to all pediatric cardiologists in order to understand mechanisms of pathophysiology, pharmacotherapeutic concepts, and to understand the role of epigenetics in precision medicine. More >

Gabrielle C. Geddes^1,2, Erin Syverson^1,2, Michael G. Earing^1,2

Congenital Heart Disease, Vol.14, No.5, pp. 832-837, 2019, DOI:10.1111/chd.12817

Abstract Objective: To describe the first 3 years of experience of having an inpatient “cardiogenetics” program which involves medical geneticist assessment of infants with major congenital heart disease (CHD) requiring surgical intervention in the first year of life.
Patients: Patients less than a year of age admitted to Children’s Hospital of Wisconsin’s Herma Heart Institute for surgical intervention for CHD seen by the cardiogenetics program. Patients with major trisomies (13, 18, and 21) were excluded.
Outcome Measures: Utilization and yield of genetic testing, and diagnostic rate were assessed as outcome measures and compared to a baseline time period and a genetic… More >

GRACIELI DALLA NORA¹, TAMARA PASTORI¹, HAYWOOD DAIL LAUGHINGHOUSE IV^2,3, THAIS SCOTTI DO CANTO-DOROW¹, SOLANGE BOSIO TEDESCO^1*

BIOCELL, Vol.34, No.3, pp. 95-102, 2010, DOI:10.32604/biocell.2010.34.095

Abstract Mikania glomerata is a plant used in Brazilian traditional medicine, known as ‘guaco’. It possesses anti-inflammatory properties and the aqueous extracts of its leaves are indicated for the treatment of diseases of the respiratory tract. This study aimed at evaluating the antiproliferative and genotoxic effect of Mikania glomerata leaf infusions on the cell cycle of onion. The material used was collected in the native environment from Rio Grande do Sul State, Brazil. Aqueous extracts through infusions were prepared in two concentrations: 4g/L (usual concentration) and 16g/L (4x more concentrated) of each of the populations. Two groups of four onion bulbs… More >

PATRÍCIA CARVALHO DE SOUZA, ANDRÉ SALIM KHAYAT, IGOR CHAMON SELIGMANN, ROMMEL MARIO RODRÍGUEZ BURBANO

BIOCELL, Vol.32, No.2, pp. 207-210, 2008, DOI:10.32604/biocell.2008.32.207

Abstract The collared peccary (Tayassu tajacu) is widely distributed over the American continent, being found from the south of the USA to the north of Argentina. In Brazil, it is spread all over the country, being one of the potential species to be raised in captivity. Therefore, the cytogenetic techniques could be a potential tool for reproductive monitoring of animals raised in captivity, mainly when destined for commercial purposes. This study had the objective of determining the chromosome number of two populations raised in captivity and characterizing them by GTG banding. For this purpose, an analysis was made of mitotic metaphases… More >

ALICIA VIVIANA LAPIERRE, MARIA ELENA ARCE, JOSÉ RAUL LOPEZ, GLADYS MARÍA CIUFFO.

BIOCELL, Vol.30, No.3, pp. 447-455, 2006, DOI:10.32604/biocell.2006.30.447

Abstract Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. The A¹¹⁶⁶C polymorphism of the AT₁ receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A¹¹⁶⁶C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence of the C¹¹⁶⁶… More >

Nathaniel Huebsch^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 107-108, 2019, DOI:10.32604/mcb.2019.08524

Abstract This article has no abstract. More >