RAQUEL GÓMEZ-MOLINA^1,*, RAQUEL MARTÍNEZ^2,3,4, MIGUEL SUÁREZ^2,3,4,*, ANA PEÑA-CABIA¹, MARíA CONCEPCIóN CALDERÓN¹, JORGE MATEO^3,4

Oncology Research, Vol.33, No.7, pp. 1531-1545, 2025, DOI:10.32604/or.2025.063951 - 26 June 2025

Abstract Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition associated with a higher risk of colorectal cancer (CRC) and other cancers. It is caused by germline mutations in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6 and PMS2. These mutations lead to microsatellite instability (MSI) and defective DNA repair mechanisms, resulting in increased cancer risk. Early detection of LS is crucial for effective management and cancer prevention. Endoscopic surveillance, particularly regular colonoscopy, is recommended for individuals with LS to detect CRC at early stages. Additionally, universal screening of CRC for More > Graphic Abstract

Noor Ayesha¹, Muhammad Mujahid², Abeer Rashad Mirdad², Faten S. Alamri^3,*, Amjad R. Khan²

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1883-1899, 2025, DOI:10.32604/cmc.2025.063560 - 09 June 2025

Abstract Large language models (LLMs) and natural language processing (NLP) have significant promise to improve efficiency and refine healthcare decision-making and clinical results. Numerous domains, including healthcare, are rapidly adopting LLMs for the classification of biomedical textual data in medical research. The LLM can derive insights from intricate, extensive, unstructured training data. Variants need to be accurately identified and classified to advance genetic research, provide individualized treatment, and assist physicians in making better choices. However, the sophisticated and perplexing language of medical reports is often beyond the capabilities of the devices we now utilize. Such an… More >

Gege Liu^#, Houfang Zhang^#, Yunhui Peng^*

BIOCELL, Vol.49, No.4, pp. 519-538, 2025, DOI:10.32604/biocell.2025.061470 - 30 April 2025

Abstract Nucleosomes play a vital role in chromatin organization and gene regulation, acting as key hubs that interact with various chromatin-associated factors through diverse binding mechanisms. Recent research has highlighted the prevalence of mutations in linker histones across different types of cancer, emphasizing their critical involvement in cancer progression. These cancer-associated mutations in linker histones have been shown to disrupt nucleosome stacking and the formation of higher-order chromatin structures, which in turn significantly affect epigenetic regulatory processes. In this review, we provide a comprehensive analysis of how cancer-associated linker histone mutations alter their physicochemical properties, influencing More >

MILICA KONTIC^1,2,*, FILIP MARKOVIC¹

Oncology Research, Vol.33, No.4, pp. 781-793, 2025, DOI:10.32604/or.2024.057231 - 19 March 2025

Abstract Detecting lung cancer early is crucial for improving survival rates, yet it remains a significant challenge due to many cases being diagnosed at advanced stages. This review aims to provide advances in epigenetics which have highlighted DNA methylation patterns as promising biomarkers for early detection, prognosis, and treatment response in lung cancer. Techniques like bisulfite conversion followed by PCR, digital droplet polymerase chain reaction, and next-generation sequencing are commonly used for detecting these methylation patterns, which occur early in the cancer development process and can be detected in non-invasive samples like blood and sputum. Key… More >

AHMAD SHAHIR MOHAMAD NAZRI, NAZIHAH MOHD YUNUS, MARAHAINI MUSA^*

BIOCELL, Vol.49, No.1, pp. 149-160, 2025, DOI:10.32604/biocell.2024.057352 - 24 January 2025

Abstract Pediatric inflammatory bowel disease (IBD) is a chronic and heterogeneous disease. IBD is commonly classified into Crohn’s disease and ulcerative colitis. It is linked to serious symptoms and complications. The onset of IBD commonly occurs during adolescence. Despite the significant number of cases globally (~5 million), the causes of pediatric IBD, which constitutes 25% of IBD patients, are not yet fully understood. Apart from environmental factors, genetic factors contribute to a higher risk of developing IBD. The predisposition risk of IBD can be investigated using genetic testing. Genetic mechanisms of pediatric IBD are highly complex More >

Shuliang Xia^1,2,3,#, Huikang Tao^2,#, Shixin Su⁴, Xinxin Chen², Li Ma², Jianru Li⁵, Bei Gao⁶, Xumei Liu⁵, Lei Pi⁷, Jinqing Feng⁴, Fengxiang Li², Jia Li^4,*, Zhiwei Zhang^1,3,*

Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583 - 16 May 2024

Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More > Graphic Abstract

TINGTING LIU^1,#, YIWEI HAO^2,#, LIFENG ZHAO^2,*

BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130 - 06 May 2024

Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry… More >

Ankita Kundu¹, Abir Das¹, Sayan Pal¹, Arijit Ghosh¹, Malay Kumar Adak^1,*, Masayuki Fujita², Mirza Hasanuzzaman^3,*

Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2283-2300, 2023, DOI:10.32604/phyton.2023.028178 - 25 June 2023

Abstract The process of ripening involves physiological and biochemical events that become a concern during postharvest storage. We have documented different approaches for the preservation and maintenance of fruit quality during the postharvest period that are biocompatible and fully safe for consumption. Chemical residues that sustain sensory characteristics, such as color, flavor, aroma, and texture, are considered. In fruit ripening, both physical and chemical elicitors are described that regulate ethylene biosynthesis or its signaling for gene expression. The key regulatory enzymes, such as ACC synthase and ACC oxidase, for ethylene biosynthesis, are important for both climacteric… More >

QIAO ZHOU^1,2,3, JIAN LIU^2,4, LING XIN⁴, YANYAN FANG^2,4, LEI WAN^2,4, DAN HUANG^2,4, JINCHEN GUO¹, JIANTING WEN^2,4

BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698 - 08 March 2023

Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age, environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has been shown to have an important role in the etiology of OA and is a More >

Usama Abdur Rahman^1,*, C. Jayakumar², Deepak Dahiya³, C.R. Rene Robin⁴

Computer Systems Science and Engineering, Vol.45, No.1, pp. 409-426, 2023, DOI:10.32604/csse.2023.026846 - 16 August 2022

Abstract As a component of Wireless Sensor Network (WSN), Visual-WSN (VWSN) utilizes cameras to obtain relevant data including visual recordings and static images. Data from the camera is sent to energy efficient sink to extract key-information out of it. VWSN applications range from health care monitoring to military surveillance. In a network with VWSN, there are multiple challenges to move high volume data from a source location to a target and the key challenges include energy, memory and I/O resources. In this case, Mobile Sinks(MS) can be employed for data collection which not only collects information… More >