KANIZ FATEMA, ZACHARY LARSON, JARED BARROTT^*

BIOCELL, Vol.46, No.10, pp. 2177-2193, 2022, DOI:10.32604/biocell.2022.020141 - 13 June 2022

Abstract Osteosarcoma is one of the most genomically complex cancers and as result, it has been difficult to assign genomic aberrations that contribute to disease progression and patient outcome consistently across samples. One potential source for correlating osteosarcoma and genomic biomarkers is within the non-coding regions of RNA that are differentially expressed. However, it is unsurprising that a cancer classification that is fraught with genomic instability is likely to have numerous studies correlating non-coding RNA expression and function have been published on the subject. This review undertakes the formidable task of evaluating the published literature of… More >

M. Ashraf Ahangar¹, Shabir Hussain Wani^1,*, Zahoor A. Dar², Jan Roohi¹, Fayaz Mohiddin¹, Monika Bansal³, Mukesh Choudhary⁴, Sumit K. Aggarwal⁴, S. A. Waza¹, Khursheed Ahmad Dar⁵, Ayman El Sabagh^6,7, Celaleddin Barutcular⁸, Omer Konuşkan⁹, Mohammad Anwar Hossain^10,*

Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2111-2133, 2022, DOI:10.32604/phyton.2022.020721 - 30 May 2022

Abstract Maize is cultivated extensively throughout the world and has the highest production among cereals. However, Northern corn leaf blight (NCLB) disease caused by Exherohilum turcicum, is the most devastating limiting factor of maize production. The disease causes immense losses to corn yield if it develops prior or during the tasseling and silking stages of crop development. It has a worldwide distribution and its development is favoured by cool to moderate temperatures with high relative humidity. The prevalence of the disease has increased in recent years and new races of the pathogen have been reported worldwide. The… More >

Muhammad Haroon Aftab¹, Kamel Jebreen^2,*, Mohammad Issa Sowaity³, Muhammad Hussain⁴

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 1225-1236, 2022, DOI:10.32604/cmc.2022.029009 - 18 May 2022

Abstract In this article, we study different molecular structures such as Polythiophene network, for and , Orthosilicate (Nesosilicate) , Pyrosilicates (Sorosilicates) , Chain silicates (Pyroxenes), and Cyclic silicates (Ring Silicates) for their cardinalities, chromatic numbers, graph variations, eigenvalues obtained from the adjacency matrices which are square matrices in order and their corresponding characteristics polynomials. We convert the general structures of these chemical networks in to mathematical graphical structures. We transform the molecular structures of these chemical networks which are mentioned above, into a simple and undirected planar graph and sketch them with various techniques of mathematics.… More >

FRANCESCO PADUANO^1,2,*, EMANUELA ALTOMARE^2,3, BENEDETTA MARRELLI¹, VINCENZO DATTILO⁴, HAIZAL MOHD HUSSAINI⁵, PAUL ROY COOPER⁵, MARCO TATULLO⁶

BIOCELL, Vol.46, No.8, pp. 1827-1835, 2022, DOI:10.32604/biocell.2022.020462 - 22 April 2022

Abstract Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN) category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific community. GWAS have identified several pathways involved in the interactions among general risk factors and genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis, involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases More >

Xingyu Zhu^1,2,#, Yongjun Wang^3,#, Shuang Chang^4,#, Yue Su², Cuixia He¹, Shuang Hu⁵, Minhui Zhu¹, Yuzhou Ding², Nuannuan Ren², Qizhi Wang², Jing Xie^1,*, Huan Zhou^1,2,*

Oncologie, Vol.23, No.4, pp. 569-588, 2021, DOI:10.32604/oncologie.2021.018869 - 31 December 2021

Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the More >

KAVITHA GOVARTHANAN^1,*, PIYUSH KUMAR GUPTA², BINITA ZIPPORAHE¹, REKHA GAHTORI³, SOUMYA PANDIT², RAM PRASAD^4,*

BIOCELL, Vol.45, No.3, pp. 501-515, 2021, DOI:10.32604/biocell.2021.014441 - 03 March 2021

Abstract Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined function. Tissue-specific stem cells are compartmentalized in a niche, which keeps the stem cells under quiescent condition. Thus, understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human applications. Given the developmental aspects of the cell, the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the cell.… More >

Gabrielle C. Geddes^1,2, Erin Syverson^1,2, Michael G. Earing^1,2

Congenital Heart Disease, Vol.14, No.5, pp. 832-837, 2019, DOI:10.1111/chd.12817

Abstract Objective: To describe the first 3 years of experience of having an inpatient “cardiogenetics” program which involves medical geneticist assessment of infants with major congenital heart disease (CHD) requiring surgical intervention in the first year of life.
Patients: Patients less than a year of age admitted to Children’s Hospital of Wisconsin’s Herma Heart Institute for surgical intervention for CHD seen by the cardiogenetics program. Patients with major trisomies (13, 18, and 21) were excluded.
Outcome Measures: Utilization and yield of genetic testing, and diagnostic rate were assessed as outcome measures and compared to a baseline time period and… More >

Nathaniel Huebsch^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 107-108, 2019, DOI:10.32604/mcb.2019.08524

Abstract This article has no abstract. More >

Andrew D. Spearman

Congenital Heart Disease, Vol.12, No.6, pp. 828-833, 2017, DOI:10.1111/chd.12543

Abstract A genetic basis of congenital heart disease (CHD) has been known for decades. In addition to the sequence of the genome, the contribution of epigenetics to pediatric cardiology is increasingly recognized. Multiple epigenetic mechanisms, including DNA methylation, histone modification, and RNA-based regulation, are known mediators of cardiovascular disease, including both development and progression of CHD and its sequelae. Basic understanding of the concepts of epigenetics will be essential to all pediatric cardiologists in order to understand mechanisms of pathophysiology, pharmacotherapeutic concepts, and to understand the role of epigenetics in precision medicine. More >

GRACIELI DALLA NORA¹, TAMARA PASTORI¹, HAYWOOD DAIL LAUGHINGHOUSE IV^2,3, THAIS SCOTTI DO CANTO-DOROW¹, SOLANGE BOSIO TEDESCO^1*

BIOCELL, Vol.34, No.3, pp. 95-102, 2010, DOI:10.32604/biocell.2010.34.095

Abstract Mikania glomerata is a plant used in Brazilian traditional medicine, known as ‘guaco’. It possesses anti-inflammatory properties and the aqueous extracts of its leaves are indicated for the treatment of diseases of the respiratory tract. This study aimed at evaluating the antiproliferative and genotoxic effect of Mikania glomerata leaf infusions on the cell cycle of onion. The material used was collected in the native environment from Rio Grande do Sul State, Brazil. Aqueous extracts through infusions were prepared in two concentrations: 4g/L (usual concentration) and 16g/L (4x more concentrated) of each of the populations. Two groups of… More >