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  • Open Access

    ARTICLE

    Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer

    RUONAN GU1,2, WENJING GUO2, WENYANG WANG1, GUIHUAN LI1, XIAOJU LAI1, ZHIBIN HUANG1, WANLU ZHAO1, ZHICONG WU1, HUA CHEN1, WENYANG LUO1, FANGYIN ZENG3,*, FAN DENG1,*

    BIOCELL, Vol.45, No.6, pp. 1585-1599, 2021, DOI:10.32604/biocell.2021.017016 - 01 September 2021

    Abstract Propofol, a common intravenous anesthetic used in clinical, has been shown to regulate cells proliferation, inflammation, angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer. However, the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown. The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer (CRC). Scratches assay, Transwell assay were used to detect colon cells migration and invasion. Real-time Quantitative Polymerase Chain Reaction (RT-qPCR), Western blotting were utilized to detect… More >

  • Open Access

    ARTICLE

    Preparation and Properties of Bio-Based Flame Retardant L-APP/Poly(L-lactic acid) Composites

    Qionglin Luo1, Mingliang Wang2, Hui Zhang1, Yuejun Ouyang1, Hongwei Lin1, You Shu1,*, Shengpei Su1,2,*

    Journal of Renewable Materials, Vol.9, No.12, pp. 2067-2076, 2021, DOI:10.32604/jrm.2021.016255 - 22 June 2021

    Abstract Poly(L-lactic acid) (PLLA) is a thermoplastic material with complete degradability, high biocompatibility and excellent mechanical properties. It can replace petroleum-based polymers are currently being used in the fields of packaging, agriculture, textiles, medical and so on. However, PLLA’s extremely flammability greatly limits its wider application. An bio-based flame retardant L-APP/PLLA composites was prepared by melt blending of the L-APP and PLLA. The morphology, impact properties, thermal properties and flame retardant properties of composites were investigated by field emission scanning electron microscope (SEM), impact tester, differential scanning calorimeter (DSC), thermogravimetric analyzer (TGA), limiting oxygen indexer (LOI)… More > Graphic Abstract

    Preparation and Properties of Bio-Based Flame Retardant L-APP/Poly(L-lactic acid) Composites

  • Open Access

    ARTICLE

    Improvement in the Performance of the Polylactic Acid Composites by Using Deep Eutectic Solvent Treated Pulp Fiber

    Lei Tan, Liangxian Liu, Chaodong Liu, Weihong Wang*

    Journal of Renewable Materials, Vol.9, No.11, pp. 1897-1911, 2021, DOI:10.32604/jrm.2021.016418 - 04 June 2021

    Abstract As the most favorable alternative to petroleum-based polymers, polylactic acid (PLA) which is the most promising degradable polymer has attracted increasing attention. However, the addition of cellulose to improve its strength often results in a reduction in its toughness. In this work, microscale cellulose is first prepared from pulp fibers by using a deep eutectic solvent, and then is used as the reinforcement of PLA. A microcrystalline cellulose (MCC)/PLA sheet with uniform texture is obtained by the solution mixing, melt blending, hot-pressing and cold-pressing process. The effects of MCC on the crystallization, thermal stability and… More >

  • Open Access

    ARTICLE

    Effects of Selected Printing Parameters on the Fire Properties of 3D-Printed Neat Polylactic Acid (PLA) and Wood/PLA Composites

    Nataša Knez1, Mirko Kariž2, Friderik Knez1, Nadir Ayrilmis3,*, Manja Kitek Kuzman2,*

    Journal of Renewable Materials, Vol.9, No.11, pp. 1883-1895, 2021, DOI:10.32604/jrm.2021.016128 - 04 June 2021

    Abstract The effects of selected printing parameters on the fire properties of additively produced composites from neat polylactic acid (PLA) and wood/PLA filaments were investigated. The reaction to fire of the 3D-printed specimens was tested according to the ISO 5660-1 cone calorimeter test method. The results showed that the properties of the specimens when exposed to fire were significantly affected by the incorporation of wood flour into the PLA filament. It was also interesting that PLA specimens had much better reactions to fire than the wood/PLA specimens. Time to ignition was found to be much longer More >

  • Open Access

    ARTICLE

    Preparation and Characterization of Electrospun Polylactic Acid Micro/Nanofibers under Different Solvent Conditions

    Hao Dou1,2,*, Hongxia Liu1,2, Feng Wang1,2, Yanli Sun1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.3, pp. 629-638, 2021, DOI:10.32604/fdmp.2021.015612 - 29 April 2021

    Abstract Electrospinning is a versatile and popular method for the fabrication of ultrafine fibers and many parameters in electrospinning can be adjusted when ideal micro/nanofibers are required. In particular, the selection of a proper solvent condition is a fundamental and crucial step to produce electrospun ultrafine fibers. In this study, a commonly used biomaterial, polylactic acid (PLA), was dissolved in 7 different solvents and PLA micro/nanofibers were prepared by electrospinning. The morphology, porosity, mechanical property and static contact angle were characterized to determine the quality of the obtained product. The results show that different solvent conditions More >

  • Open Access

    ARTICLE

    The Application of Cellulose Nanocrystals Modified with Succinic Anhydride under the Microwave Irradiation for Preparation of Polylactic Acid Nanocomposites

    Ewa Szefer*, Agnieszka Leszczyńska, Edyta Hebda, Krzysztof Pielichowski

    Journal of Renewable Materials, Vol.9, No.6, pp. 1127-1142, 2021, DOI:10.32604/jrm.2021.014584 - 11 March 2021

    Abstract The aim of this work was to use cellulose nanocrystals that were obtained by hydrolysis in phosphoric acid solution and further modified with succinic anhydride in the microwave field for PLA reinforcement. A series of all-bionanocomposites containing unmodified and surface modified cellulose nanocrystals with CNC content in the range of 1–3 %w.t. were obtained by melt blending and tested by XRD, SEM, DSC and DMA to investigate the effect of surface esterification of CNCs on the structure, morphology, dynamic mechanical properties of bionanocomposites, as well as phase transitions of PLA in the presence of cellulosic nanofiller. More > Graphic Abstract

    The Application of Cellulose Nanocrystals Modified with Succinic Anhydride under the Microwave Irradiation for Preparation of Polylactic Acid Nanocomposites

  • Open Access

    ARTICLE

    Melt Extrusion of Environmentally Friendly Poly(L-lactic acid)/Sodium Metabisulfite Films for Antimicrobial Packaging Applications

    Norma M. P. Machado1, Gustavo C. Melo1, Matheus F. Camargo1, Giulianna G. Feijó1, Bruna M. S. Putton2, Clarice Steffens2, Rogerio L. Cansian2, Luiz A. Pessan1, Francys K. V. Moreira1,*

    Journal of Renewable Materials, Vol.9, No.2, pp. 337-349, 2021, DOI:10.32604/jrm.2021.011081 - 15 December 2020

    Abstract Food packaging materials compounded with antimicrobial additives can substantially diminish the incidence of foodborne diseases. Here, poly(L-lactic acid) (PLA) films containing sodium metabisulfite (NaM) were produced by melt extrusion as an attempt to develop a new biodegradable material with antimicrobial properties for packaging. Life cycle assessment (LCA) simulations revealed that the environmental footprints of the PLA film did not change upon NaM addition, and that NaM is more eco-friendly than silver nanoparticles. The PLA/NaM films with NaM content varying from 0.5 to 5.0 wt.% were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and… More >

  • Open Access

    ARTICLE

    3D Printing of Polylactic Acid Bioplastic–Carbon Fibres and Twisted Kevlar Composites Through Coextrusion Using Fused Deposition Modeling

    J. Y. Tey*, W. H. Yeo, Y. J. King, W. O. Ding

    Journal of Renewable Materials, Vol.8, No.12, pp. 1671-1680, 2020, DOI:10.32604/jrm.2020.011870 - 12 November 2020

    Abstract Polylactic acid (PLA) bioplastic is a common material used in Fused Deposition Modeling (FDM) 3D printing. It is biodegradable and environmentally friendly biopolymer which made out of corn. However, it exhibits weak mechanical properties which reduced its usability as a functional prototype in a real-world application. In the present study, two PLA composites are created through coextruded with 3K carbon fibres and twisted Kevlar string (as core fibre) to form a fibre reinforced parts (FRP). The mechanical strength of printed parts was examined using ASTM D638 standard with a strain rate of 1 mm/min. It… More >

  • Open Access

    ARTICLE

    3D-Printed PLA Filaments Reinforced with Nanofibrillated Cellulose

    Matea Perić1,*, Robert Putz1, Christian Paulik2

    Journal of Renewable Materials, Vol.8, No.7, pp. 759-772, 2020, DOI:10.32604/jrm.2020.09284 - 01 June 2020

    Abstract In the current study poly(lactic acid) PLA composites with a 3 wt% and 5 wt% of nanofibrillated cellulose (NFC) were produced by 3D-printing method. An enzymatic pretreatment coupled with mechanical fibrillation in a twin screw extruder was used to produce high consistency NFC. Scanning electron microscopy (SEM) equipped with Fibermetric software, FASEP fiber length distribution analysis, Furrier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), tensile tests, impact tests and differential scanning calorimetry were used to characterize NFC and PLA/NFC composites. The results of the fiber length and width measurements together with the results of the… More >

  • Open Access

    ARTICLE

    Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals

    Mariia Stepanova1, Ilia Averianov1, Olga Solomakha1, Natalia Zabolotnykh2, Iosif Gofman1, Mikhail Serdobintsev2, Tatiana Vinogradova2, Viktor Korzhikov-Vlakh1,3, Evgenia Korzhikova-Vlakh1,3,*

    Journal of Renewable Materials, Vol.8, No.4, pp. 383-395, 2020, DOI:10.32604/jrm.2020.09206 - 24 April 2020

    Abstract The biocomposite films were prepared from poly(L-lactic acid) and cellulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties, cellulose was functionalized with poly(glutamic acid). The modified cellulose nanocrystals were better distributed and less aggregated within the matrix, which was testified by scanning electron, optical and polarized light microscopy. According to mechanical tests, composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus, elongation at break and tensile strength. Incubation of composite materials in model buffer solutions for 30 weeks More >

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