Lilan Gao^1,2,*, Qingxian Yuan^1,2, Ruixin Li^3,*, Lei Chen^1,2, Chunqiu Zhang^1,2, Xizheng Zhang^1,2

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 85-98, 2018, DOI: 10.3970/mcb.2018.00329

Abstract Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing stage and the second stable… More >

Ruikai Chen¹, Delphine Dean^1,*

Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 153-169, 2017, DOI:10.3970/mcb.2017.014.153

Abstract Vascular smooth muscle cells (VSMCs) play an important role in regulating blood flow and pressure by contracting and relaxing in response to a variety of mechanical stimuli. A fully differentiated and functional VSMC should have both the ability to contract and relax in response to environmental stimuli. In addition, it should have the proper mechanical properties to sustain the mechanically active vascular environment. Stem cells can differentiate towards VSMC lineages and so could be used as a potential treatment for vascular repair. However, few studies have assessed the time it takes for stems cells to acquire similar mechanical property to… More >

Xituan Shang^*, Michael R. T. Yen^1,†, M. Waleed Gaber^‡

Molecular & Cellular Biomechanics, Vol.7, No.2, pp. 93-104, 2010, DOI:10.3970/mcb.2010.007.093

Abstract The objective of this research is to conduct mechanical property studies of skin from two individual but potentially connected aspects. One is to determine the mechanical properties of the skin experimentally by biaxial tests, and the other is to use the finite element method to model the skin properties. Dynamic biaxial tests were performed on 16 pieces of abdominal skin specimen from rats. Typical biaxial stress-strain responses show that skin possesses anisotropy, nonlinearity and hysteresis. To describe the stress-strain relationship in forms of strain energy function, the material constants of each specimen were obtained and the results show a high… More >

Q Wang^*, YP Zheng^∗,†, HJ Niu^∗,‡

Molecular & Cellular Biomechanics, Vol.7, No.1, pp. 45-58, 2010, DOI:10.3970/mcb.2010.007.045

Abstract This study aims to obtain osmosis-induced swelling strains of normal and proteoglycan (PG) depleted articular cartilage using an ultrasound system and to investigate the changes in its mechanical properties due to the PG depletion using a layered triphasic model. The swelling strains of 20 cylindrical cartilage-bone samples collected from different bovine patellae were induced by decreasing the concentration of bath saline and monitored by the ultrasound system. The samples were subsequently digested by a trypsin solution for approximately 20 min to deplete proteoglycans, and the swelling behaviors of the digested samples were measured again. The bi-layered triphasic model proposed in… More >

Judith Su^∗, Ricardo R. Brau^†, Xingyu Jiang^‡, George M. Whitesides^§, Matthew J. Lang^¶, Peter T. C. So^||

Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 105-118, 2007, DOI:10.3970/mcb.2007.004.105

Abstract During migration, asymmetrically polarized cells achieve motion by coordinating the protrusion and retraction of their leading and trailing edges, respectively. Although it is well known that local changes in the dynamics of actin cytoskeleton remodeling drive these processes, neither the cytoskeletal rheological properties of these migrating cells are well quantified nor is it understand how these rheological properties are regulated by underlying molecular processes. In this report, we have used soft lithography to create morphologically polarized cells in order to examine rheological differences between the front and rear zone of an NIH 3T3 cell posed for migration. In addition, we… More >

Judith Su^∗, Xingyu Jiang^†, Roy Welsch^‡, George M. Whitesides^§, Peter T. C. So^¶

Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 87-104, 2007, DOI:10.3970/mcb.2007.004.087

Abstract Interactions between the cell and the extracellular matrix regulate a variety of cellular properties and functions, including cellular rheology. In the present study of cellular adhesion, area was controlled by confining NIH 3T3 fibroblast cells to circular micropatterned islands of defined size. The shear moduli of cells adhering to islands of well defined geometry, as measured by magnetic microrheometry, was found to have a significantly lower variance than those of cells allowed to spread on unpatterned surfaces. We observe that the area of cellular adhesion influences shear modulus. Rheological measurements further indicate that cellular shear modulus is a biphasic function… More >

Igor Grešovnik^1,2, Tadej Kodelja¹, Robert Vertnik^2,3, Bojan Senčič^3,2,3, Božidar Šarler^1,2,4

CMC-Computers, Materials & Continua, Vol.30, No.1, pp. 19-38, 2012, DOI:10.3970/cmc.2012.030.019

Abstract Artificial neural networks (ANNs) are employed as an alternative to physical modeling for calculation of the relations between the production path process parameters (melting of scrap steel and alloying, continuous casting, hydrogen removal, reheating, rolling, and cooling on a cooling bed) and the final product mechanical properties (elongation, tensile strength, yield stress, hardness after rolling, necking) of steel semi products. They provide a much faster technique of response evaluation complementary to physical modeling. The Štore Steel company process path for production of steel bars is used as an example for demonstrating the approach. The applied ANN is of a multilayer… More >

Deli Gao¹, Zengxin Zhao²

CMC-Computers, Materials & Continua, Vol.26, No.2, pp. 157-166, 2011, DOI:10.3970/cmc.2011.026.157

Abstract The research on casing corrosion in sour environment by a synergism of sweet corrosion and H₂S corrosion has become the basis of casing selection and casing string safety evaluation with more and more sour reservoirs containing high H₂S concentration being developed. It is essential to scientifically utilize casing service ability and reasonably control production rate of gas well to achieve the effective and safe developing of gas resources during the safety period of casing service with a precise casing life prediction. Scanning electron microscopy and tensile testing were applied to investigate the corrosion of TP110TS tube steel in stimulant solution… More >

Zihao Yang¹, Junzhi Cui², Yufeng Nie¹, Yatao Wu¹, Bin Yang³, Bo Wu⁴

CMC-Computers, Materials & Continua, Vol.38, No.3, pp. 175-194, 2013, DOI:10.3970/cmc.2013.038.175

Abstract This study is concerned with the microstructural modeling and mechanical properties computation of three-dimensional (3D) 4-directional braided composites. Microstructure of the braided composite determines its mechanical properties and a precise geometry modeling of the composite is essential to predict the material properties. On the basis of microscopic observation, a new parameterized microstructural unit cell model is established in this paper. And this model truly simulates the microstructure of the braided composites. Furthermore, the mathematical relationships among the structural parameters, including the braiding angle, fiber volume fraction and braiding bitch, are derived. By using the unit cell model, the second-order two-scale… More >

Chang-Chun Lee^1,*, Pei-Chen Huang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.2, pp. 239-260, 2019, DOI:10.32604/cmes.2019.06859

Abstract This research reviews the application of computational mechanics on the properties of nano/micro scaled thin films, in which the application of different computational methods is included. The concept and fundamental theories of concerned applications, material behavior estimations, interfacial delamination behavior, strain engineering, and multilevel modeling are thoroughly discussed. Moreover, an example of an interfacial adhesion estimation is presented to systematically estimate the related mechanical reliability issue in the microelectronic industry. The presented results show that the peeled mode fracture is the dominant delamination behavior of layered material system, with high stiffness along the bonding interface. However, the shear mode fracture… More >