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  • Open Access


    Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds


    BIOCELL, Vol.47, No.1, pp. 51-69, 2023, DOI:10.32604/biocell.2022.023392

    Abstract Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, an infection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the time point of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. A neurodevelopmental defect may be associated with a More >

  • Open Access


    Ampelopsin Inhibits Breast Cancer Glucose Metabolism Reprogramming Based on Network Pharmacology and Molecular Docking

    Rong Zeng1,#, Lin Liu1,2,#, Jingshan Zhao1,2,3,#, Wenmei Zhang3, Guohong Zhang1, Yunfeng Li1,2,*

    Oncologie, Vol.24, No.3, pp. 483-498, 2022, DOI:10.32604/oncologie.2022.025148

    Abstract Background: Breast cancer (BC) is the most frequent type of gynecology tumors with high morbidity and mortality. Ampelopsin, the main active compound of Ampelopsis grossedentata, exerts an anti-tumor effect on a variety of cancers. However, the anti-cancer role of ampelopsin in BC remains unclear. The aim of this study is to explore the mechanism of ampelopsin against breast cancer. Materials and Methods: The target genes of ampelopsin in the treatment of breast cancer were determined and analyzed by network pharmacology and molecular docking. Cytoscape software was used to identify the core target genes and construct a protein–protein interaction… More >

  • Open Access


    Effects of arbuscular mycorrhizal fungi and plant growth-promoting rhizobacteria on growth and reactive oxygen metabolism of tomato fruits under low saline conditions


    BIOCELL, Vol.46, No.12, pp. 2575-2582, 2022, DOI:10.32604/biocell.2022.021910

    Abstract Land salinization is a major form of land degradation, which is not conducive to the growth and quality of fruits and vegetables. Plant salt tolerance can be enhanced by arbuscular mycorrhizal fungi (AMF) or plant growth-promoting rhizobacteria (PGPR). This study examined the effects of inoculation with PGPR singly or in combination with AMF, on the growth and quality of tomato fruits under low saline conditions. Tomatoes were cultivated in a greenhouse with sterilized soil, inoculated with PGPR, AMF, or co-inoculated with PGPR and AMF, and NaCl solution (1%) was added to the soil. The results… More >

  • Open Access


    Effects of Drought Stress on Key Enzymes of Carbon Metabolism, Photosynthetic Characteristics and Agronomic Traits of Soybean at the Flowering Stage under Different Soil Substrates

    Shuang Song1, Xiaomei Li2, Xin Wang1, Qi Zhou1, Yongping Li1, Xiaojing Wang1, Shoukun Dong1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.11, pp. 2475-2490, 2022, DOI:10.32604/phyton.2022.021090

    Abstract Soybean is an important legume food crop, and its seeds are rich in nutrients, providing humans and animals with edible oil and protein feed. However, soybean is sensitive to water requirements, and drought is an important factor limiting soybean yield and quality. This study used Heinong 84 (drought resistant variety) and Hefeng 46 (intermediate variety) as tested varieties planted in chernozem, albic, and black soils. The effects of drought stress on the activities of key enzymes in carbon metabolism and photosynthetic characteristics of soybean were studied during the flowering stage, most sensitive to water. (1)… More >

  • Open Access


    Uridine dynamic administration affects the circadian variation of bile acid metabolism in high-fat-diet-fed mice


    BIOCELL, Vol.46, No.11, pp. 2433-2442, 2022, DOI:10.32604/biocell.2022.021290

    Abstract High-fat diet (HFD) is demonstrated to disturb the bile acid metabolism. The rhythm of bile acid metabolism can also be affected by uridine, whose metabolism exhibits a daily rhythm. However, the mechanism of dynamic uridine administration affecting bile acid during HFD remains unclear. In this study, C57BL/6J mice were fed HFD (the control group; CON) or HFD with oral administration of uridine in the daytime (DUR) and nighttime (NUR) to investigate the mechanism of the effect of uridine on the bile acid. This study showed that the mRNA expression of uridine transporters and circadian clock… More >

  • Open Access


    Ready to migrate? Reading cellular signs of migration in an epithelial to mesenchymal transition model


    BIOCELL, Vol.46, No.11, pp. 2353-2356, 2022, DOI:10.32604/biocell.2022.020966

    Abstract The epithelial to mesenchymal transition (EMT) is a cellular program that drives de-differentiation of cells in both physiological and pathological processes. One of the characteristics of cells describing an EMT is the (re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism. The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with More >

  • Open Access


    Comprehensive analysis reveals an arachidonic acid metabolism-related gene signature in patients with pancreatic ductal adenocarcinoma


    BIOCELL, Vol.46, No.10, pp. 2241-2256, 2022, DOI:10.32604/biocell.2022.020389

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, making its prognosis prediction difficult. The arachidonic acid (AA) cascade is involved in carcinogenesis. Therefore, the metabolic enzymes of the AA cascade consist of lipoxygenases (LOXs), phospholipase A2s (PLA2s), and cyclooxygenases (COXs) along with their metabolic products, including leukotrienes. Nevertheless, the prognostic potential of AA metabolism-associated PDAC has not been explored. Herein, the mRNA expression patterns and the matching clinical information of individuals with PDAC were abstracted from online data resources. We employed the LASSO Cox regression model to develop a multigene clinical signature in the TCGA queue.… More >

  • Open Access


    Organic Amendments Improve Plant Morpho-Physiology and Antioxidant Metabolism in Mitigating Drought Stress in Bread Wheat (Triticum aestivum L.)

    Taufika Islam Anee1,#, Md. Nur Nabi Islam1,#, Mohamed M. Hassan2, Abdul Awal Chowdhury Masud1, Md. Mahabub Alam1, Mirza Hasanuzzaman1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.9, pp. 1959-1972, 2022, DOI:10.32604/phyton.2022.021137

    Abstract Due to the unpredictable climate change, drought stress is being considered as one of the major threats to crop production. Wheat (Triticum aestivum L. cv. BARI Gom-26) being a dry season crop frequently faces scarcity of water and results in a lower yield. Therefore, this experiment aims to explore the role of different organic amendments (OAs) in mitigating drought stress-induced damage. The pot experiment consisted of different organic amendments viz. compost, vermicompost and poultry manure @0.09 kg m−2 soil, biochar @2.5% w/w soil and chitosan @1% w/w soil which was imposed on the plants grown under both… More >

  • Open Access


    Response of Tomato Sugar and Acid Metabolism and Fruit Quality under Different High Temperature and Relative Humidity Conditions

    Yanjiao Zheng1, Zaiqiang Yang1,2,*, Tingting Wei1, Heli Zhao1

    Phyton-International Journal of Experimental Botany, Vol.91, No.9, pp. 2033-2054, 2022, DOI:10.32604/phyton.2022.019468

    Abstract The combined stress of high temperature and high relative air humidity is one of the most serious agrometeorological disasters that restricts the production capacity of protected agriculture. However, there is little information about the precise interaction between them on tomato fruit quality. The objectives of this study were to explore the effects of the combined stress of high temperature and relative humidity on the sugar and acid metabolism and fruit quality of tomato fruits, and to determine the best relative air humidity for fruit quality under high temperature environments. Four temperature treatments (32°C, 35°C, 38°C,… More >

  • Open Access


    Proline and Oxidative Metabolism in Young Pecan Trees Associated with Sulphate Accumulation

    Dalila Jacqueline Escudero-Almanza1, Oscar Cruz-Alvarez1, Ofelia Adriana Hernández-Rodríguez1, Juan Luis Jacobo-Cuellar1, Esteban Sánchez-Chávez2, Pablo Preciado-Rángel3, Dámaris Leopoldina Ojeda-Barrios1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.6, pp. 1141-1152, 2022, DOI:10.32604/phyton.2022.019129

    Abstract Pecan [Carya illinoinensis (Wangenh.) K. Koch.] is a deciduous tree whose fruits (nuts) are of high economic value and offer excellent nutritional benefits. However, soils high in sulphates can limit its growth and development. Working with 5-year-old trees of ‘Western Schley’ pecan grown in soils high in sulphates, the levels of proline and oxidative metabolism were recorded in the leaflets. Results showed that different levels of visible leaflet damage (‘sufficiency’, ‘low’, ‘moderate’ or ‘severe’) were associated with different levels of leaflet sulphates (mg kg−1): ‘sufficiency’ (≤40), ‘low’ (41–60), ‘moderate’ (61–80) and ‘severe’ (80–100). ‘Severe’ sulphate damage was… More >

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