Danlong Jing^1,2, Nan Wang¹, Nan Lu¹, Guanzheng Qu³, Guolu Liang², Wenjun Ma¹, Shougong Zhang^1,*, Junhui Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 507-524, 2022, DOI:10.32604/phyton.2022.017644

Abstract Lysine acetylation, a reversible and dynamic post-translational modification, plays pivotal roles in regulating many biological processes in plants. However, the information of lysine acetylation during flower development of woody angiosperm remains unclear. Herein, we identified a total of 667 lysine acetylation sites in 467 proteins in flower buds of Catalpa Bungei. The acetylated proteins were mainly involved in the pathways of carbon metabolism, glycometabolism and oxidative phosphorylation. Using functional enrichment analysis, 61 and 13 acetylated proteins were involved in the glycometabolism and oxidative phosphorylation pathways, respectively. This suggests that lysine acetylated proteins play critical roles in the energy metabolism pathways.… More >

JIAYU ZHANG^1,2,3,#, RUOYAN CAO^1,2,3,#, JIANMIN PENG^1,2,3, QINCHAO HU^1,2,3, JUAN XIA^1,2,3,*, BIN CHENG^1,2,3,*

BIOCELL, Vol.46, No.1, pp. 111-125, 2022, DOI:10.32604/biocell.2022.016612

Abstract Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head and neck squamous cell carcinoma (HNSCC). The integrative analysis of all the metabolism-related genes (MRGs) in HNSCC is lacking and the interaction between the metabolism and the immune characteristics also requires more exploration to uncover the potential mechanisms. Therefore, this study was designed to establish a prognostic signature based on all the MRGs in HNSCC. Genes of HNSCC samples were available from the TCGA and GEO databases while the MRGs were retrieved from a previous study. Ultimately 4 prognostic MRGs were selected to construct a model… More >

RONGXUE WEI¹, CHUNCHUN HAN^1,*, FENGJIANG YE¹, SHOUHAI WEI², FANG HE¹, HEHE LIU¹, LIANG LI¹, HONGYONG XU¹, SHENQIANG HU¹, XIANYIN ZENG²

BIOCELL, Vol.46, No.1, pp. 171-183, 2022, DOI:10.32604/biocell.2022.015409

Abstract In order to explore the role of forkhead box protein O1 (FoxO1) in the lipid metabolism and cell proliferation, goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, and then transfected with FoxO1 interference plasmid. The related parameters of lipid metabolism and cell proliferation were measured. The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration (P < 0.05); and increased the proliferative index (PI), cell DNA synthesis, protein expression of Cyclin D1 in goose primary hepatocytes (P < 0.05). Secondly, the co-treatment of insulin and FoxO1 interference increased the… More >

Deka Reine Judesse Soviguidi^1,2, Rui Pan¹, Yi Liu^1,2, Liping Rao^1,2, Wenying Zhang^1,*, Xinsun Yang^2,*

Phyton-International Journal of Experimental Botany, Vol.91, No.2, pp. 239-255, 2022, DOI:10.32604/phyton.2022.018284

Abstract During the evolution, plants acquired the ability to synthesize different phenylpropanoid compounds like chlorogenic acid (CGA), which plays vital roles in resistance mechanisms to abiotic stresses. These environmental factors, including heavy metal, cold, heat, ultraviolet (UV) light, drought, and salinity affect the plant physiological processes, resulting in massive losses of agriculture production. As plants evolve from green algae to bryophytes, ferns, gymnosperms and angiosperms, phenylpropanoids are produced and accumulated in different tissues, giving the plant the capacity to counteract the harmful effects of the adverse environments. Studies have been performed on the metabolic evolution of rosmarinic acid, flavonoids and lignin,… More >

XIAOMEI HAN^#, SHUYING ZHANG^#, YIFU WANG, CHANGE QI, PENGNYU GUO, YALI XU, GUANGHUI LYU^*

BIOCELL, Vol.45, No.6, pp. 1509-1519, 2021, DOI:10.32604/biocell.2021.09506

Abstract Diabetes Mellitus is a systematic disease with complications in multi-organs, including decreased implant osseointegration and a high failure rate of dental transplants. Accumulating evidence indicates that the signaling pathway directly impacts the process of bone metabolism and inflammatory response implicated with dental implants in diabetic patients. This review summarizes the recent advance in signaling pathways regulate osseointegration and inflammatory response in dental transplantation, aiming to identify the potential therapeutic target to reduce the dental transplant failure in diabetes patients, with emphasis on the surface characteristics of the implant, inflammatory signaling, AMPK, PPARγ, WNT, ROS, and adiponectin signaling. More >

SUSANA PUNTARULO^1,2, PAULA MARIELA GONZÁLEZ^1,2,*

BIOCELL, Vol.45, No.4, pp. 813-821, 2021, DOI:10.32604/biocell.2021.015360

Abstract Environmental climate conditions could lead to an increasing global occurrence of microorganism blooms that synthesize toxins in the aquatic environments. These blooms could result in significantly toxic events. Responses of photosynthetic organisms to adverse environmental conditions implicate reactive oxygen species generation; but, due to the presence of a varied cellular antioxidant defense system and complex signaling networks, this oxidative stress could act as an important factor in the environmental adaptive processes. The objective of this review was to assess how some biotoxins are implicated in the generation of oxidative and nitrosative metabolic changes, not only in biotoxin-producing organisms but also… More >

SAYEQUA DANDOTI^*

BIOCELL, Vol.45, No.4, pp. 863-884, 2021, DOI:10.32604/biocell.2021.013993

Abstract Inactivation of apoptosis is the prime phenomenon in cancer development and cancer treatments. Mutations in the apoptotic pathway not only exert resistance to apoptosis and provide a survival advantage to cancer cells but also confer resistance to cancer therapies. Escaping apoptosis is the “hallmark” of cancer cells. Cancer cells can withstand many apoptotic stimuli, such as DNA damage, unfavorable environments, and cytotoxic therapies. Substantial research has been carried out and is in good progress on the various mechanisms adopted by cancer cells to evade apoptosis. This article reviews the apoptosis escape mechanisms by cancer cells, viz. apoptotic gene alterations (in… More >

JIAHE GUO^2,#, XIAOGUANG JI^3,#, YONGJIANG MAO², ZHANGPING YANG², ZHI CHEN², YUAN YUAN^1,*

BIOCELL, Vol.45, No.4, pp. 835-847, 2021, DOI:10.32604/biocell.2021.015652

Abstract Goat milk is widely recognized for its nutritional value. Fatty acid synthase (FAS) is the crucial enzyme of fatty acid de novo synthesis. It plays an important role in the formation of goat milk fat. In this paper, we first introduced the molecular regulation process of goat milk fat metabolism based on the structure research of FAS. Secondly, we reviewed some key factors in FAS transcription and post-transcriptional regulation of the goat mammary gland and preliminarily constructed the expression network of the goat mammary gland FAS gene. The purpose of this paper is to systematically introduce the role of FAS… More >

Erkan Arslan^1,*, Ismail Koyuncu²

Oncologie, Vol.23, No.1, pp. 105-117, 2021, DOI:10.32604/Oncologie.2021.014764

Abstract Prostate cancer is the second most common cancer in men. Prostate-specific antigen (PSA) levels, commonly used in the diagnosis of prostate cancer, are increased in both malign and benign conditions, such as prostate hyperplasia (BPH) and prostatitis. Thus, more specific markers are urgently needed to discriminate between prostate cancer and benign diseases of the prostate. The purpose of this study is to examine both the intracellular and extracellular free amino acid profiles of metastatic prostate cancer cells (PC-3), normal prostate cells (PNT-1A), and metabolic changes (e.g., pH). In this study, cancer and normal cells were incubated in the appropriate medium.… More >

JI ZHU^#, XIYING BO^#, GENGXI JIANG, SHIHUA YAO, TIEJUN ZHAO^*, LING CHEN^*

BIOCELL, Vol.45, No.3, pp. 639-647, 2021, DOI:10.32604/biocell.2021.012847

Abstract Non-small cell lung cancer (NSCLC) cells intake and consume glucose at high efficiency by aerobic glycolysis to maintain robust cell growth and resist cell death. MicroRNAs (miRNAs) have been known to play pivotal roles in NSCLC development partly through mediating glycolysis. However, only a few miRNAs have been experimentally confirmed as critical regulators of glycolysis in NSCLC. TCGA datasets were analyzed to screen for differentially expressed miRNAs between NSCLC and normal tissues. The function of miR-1294-5p was determined in NSCLC cells by cell proliferation, glucose uptake, lactate release, and Extracellular Acidification Rate (ECAR) assays. The target of miR- 1294-5p was… More >