Open Access

REVIEW

The signaling pathway in modulating bone metabolism after dental implant in diabetes

XIAOMEI HAN^#, SHUYING ZHANG^#, YIFU WANG, CHANGE QI, PENGNYU GUO, YALI XU, GUANGHUI LYU^*

Department of Oral Implantology, Affiliated Hospital of Chifeng University, Chifeng, 024000, China

* Corresponding Author: GUANGHUI LYU. Email:

BIOCELL 2021, 45(6), 1509-1519. https://doi.org/10.32604/biocell.2021.09506

Received 24 December 2019; Accepted 28 April 2020; Issue published 01 September 2021

Abstract

Diabetes Mellitus is a systematic disease with complications in multi-organs, including decreased implant osseointegration and a high failure rate of dental transplants. Accumulating evidence indicates that the signaling pathway directly impacts the process of bone metabolism and inflammatory response implicated with dental implants in diabetic patients. This review summarizes the recent advance in signaling pathways regulate osseointegration and inflammatory response in dental transplantation, aiming to identify the potential therapeutic target to reduce the dental transplant failure in diabetes patients, with emphasis on the surface characteristics of the implant, inflammatory signaling, AMPK, PPARγ, WNT, ROS, and adiponectin signaling.

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