ZECHAO LU^1,#, FUCAI TANG^1,#, HAOBIN ZHOU^2,#, ZEGUANG LU^3,#, WANYAN CAI^4,#, JIAHAO ZHANG⁵, ZHICHENG TANG⁶, YONGCHANG LAI^1,*, ZHAOHUI HE^1,*

BIOCELL, Vol.47, No.2, pp. 339-350, 2023, DOI:10.32604/biocell.2023.023750 - 18 November 2022

Abstract Background: Establishing an appropriate prognostic model for PCa is essential for its effective treatment. Glycolysis is a vital energy-harvesting mechanism for tumors. Developing a prognostic model for PCa based on glycolysis-related genes is novel and has great potential. Methods: First, gene expression and clinical data of PCa patients were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), and glycolysis-related genes were obtained from the Molecular Signatures Database (MSigDB). Gene enrichment analysis was performed to verify that glycolysis functions were enriched in the genes we obtained, which were used in non-negative matrix factorization… More >

Jie Ren^1,2, Chuqiao Xu³, Junliang Wang^2,4, Jie Zhang^2,*, Xinhua Mao⁴, Wei Shen⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.1, pp. 599-618, 2023, DOI:10.32604/cmes.2022.022415 - 29 September 2022

Abstract The prognostics health management (PHM) from the systematic view is critical to the healthy continuous operation of process manufacturing systems (PMS), with different kinds of dynamic interference events. This paper proposes a three leveled digital twin model for the systematic PHM of PMSs. The unit-leveled digital twin model of each basic device unit of PMSs is constructed based on edge computing, which can provide real-time monitoring and analysis of the device status. The station-leveled digital twin models in the PMSs are designed to optimize and control the process parameters, which are deployed for the manufacturing… More >

LIPING GONG¹, MING JIA^2,*

BIOCELL, Vol.47, No.1, pp. 109-123, 2023, DOI:10.32604/biocell.2023.024620 - 26 September 2022

Abstract ATP binding cassette subfamily C member 8 (ABCC8) encodes a protein regulating the ATP-sensitive potassium channel. Whether the level of ABCC8 mRNA in lower grade glioma (LGG) correlates with immune cell infiltration and patient outcomes has not been evaluated until now. Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets. The association between ABCC8 and tumor immune cell infiltration, diverse gene mutation characteristics, tumor mutation burden (TMB), and survival in LGG was also investigated in several independent datasets. Pathway enrichment analysis was conducted to search for ABCC8-associated… More >

J. Bradley Mason^1,*, Michael Creswell^2,*, Jillian Egan¹, Christopher Dall¹, Tamir Sholklapper², Lan Anh Galloway², Joanna Orzel², Harry Lee², Sameer Desale³, Lambros Stamatakis^2,4

Canadian Journal of Urology, Vol.29, No.3, pp. 11162-11169, 2022

Abstract Introduction: To identify prognostic factors for overall survival (OS) in patients with malignant ureteral obstruction (MUO) from gynecologic malignancy (GM), with the goal of improving patient selection for urinary diversion.
Materials and methods: Retrospective review of 126 patients with MUO from GM at two academic centers from 2011-2019. Factors related to OS identified by Cox regression proportional hazard model. In patients with incomplete survival data (n = 30), hospice was used as a surrogate for death. Multivariate models and receivers operating characteristics (ROC) curves were created for hemoglobin and albumin values.
Results: Overall median survival was 6.2 months.… More >

Lei Hu^1,2,#, Meng Chen^2,3,#, Haiming Dai^2,3,4, Hongzhi Wang^2,3,4,*, Wulin Yang^2,3,4,*

Oncologie, Vol.24, No.4, pp. 803-822, 2022, DOI:10.32604/oncologie.2022.026419 - 31 December 2022

Abstract Background and Aim: Hundreds of consistently altered metabolic genes have been identified in breast cancer (BC), but their prognostic value remains to be explored. Therefore, we aimed to build a prediction model based on metabolism-related genes (MRGs) to guide BC prognosis. Methods: Current work focuses on constructing a novel MRGs signature to predict the prognosis of BC patients using MRGs derived from the Virtual Metabolic Human (VMH) database, and expression profiles and clinicopathological data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Results: The 3-MRGs-signature constructed by SERPINA1, QPRT and PXDNL was found… More >

Yao Wu^1,2,#, Bin Qu^1,#, Haoming Shen¹, Hongyu Deng¹, Faqin Tang^1,*

Oncologie, Vol.24, No.3, pp. 499-512, 2022, DOI:10.32604/oncologie.2022.024951 - 19 September 2022

Abstract Background: Tumor-specific growth factor (TSGF) is associated with invasion and metastasis of various malignancies and adverse clinical outcomes. TSGF is also highly expressed in cervical cancer (CC), but its clinical value is unclear. Materials and Methods: Serum samples from malignancies, including CC, non-Hodgkin’s lymphoma (NHL), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC), lung cancer (LCA), ovarian cancer (OC), breast cancer (BC), gastric carcinoma (GC), and pancreatic cancer (PC) were collected, and TSGF was detected using a chemiluminescence assay. The patients with CC were followed-up over five years, and their clinicopathological parameters were analyzed. Meanwhile, the pre- and post-treatment… More >

ALPASLAN OZTURK^1,*, MEHMET KARA²

BIOCELL, Vol.46, No.12, pp. 2625-2635, 2022, DOI:10.32604/biocell.2022.023124 - 10 August 2022

Abstract In this study, our aim was to examine the diagnostic and prognostic significance of lymphocyte/C-reactive protein ratio (LCR), neutrophil/lymphocyte ratio (NLR) and D-dimer parameters in COVID-19 infection. The LCR, NLR, neutrophil count, mean platelet volume (MPV), C-reactive protein (CRP), and D-dimer parameters were evaluated retrospectively. This was a retrospective cohort study with 1000 COVID-19 positive and 1000 healthy control groups, all over the age of 18 years. Odds ratio (OR) and 95% confidence interval (CI) values were calculated for each parameter found to be statistically significant in the univariate and multivariate logistic regression models. Herein,… More >

JIAMING ZHAN, WEIHUA WANG, YANLEI TANG, NING ZHOU, DAOWEN JIANG^*

BIOCELL, Vol.46, No.12, pp. 2601-2613, 2022, DOI:10.32604/biocell.2022.021300 - 10 August 2022

Abstract Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression. In this study, by comparing EC samples and normal samples, we found a total of 132 DDR expression with a significant difference. Moreover, we revealed higher expression of POLN, PALB2, ATM, PER1, TOP3B and lower expression of HMGB1, UBE2B were correlated to longer OS in EC. In addition, a prognostic risk score based on 7 DDR gene expression (POLN, HMGB1, TOP3B, PER1, UBE2B,… More >

Yi Chen^1,#, Liyun Huang^1,#, Zuwu Wei¹, Xiaoling Liu¹, Lihong Chen^1,2,*, Bin Wang^1,2,*

Oncologie, Vol.24, No.2, pp. 329-340, 2022, DOI:10.32604/oncologie.2022.022521 - 29 June 2022

Abstract Background: The effective method for predicting prognosis of ICC is still lack. This study aims to establish and verify an effective prognostic nomogram model for intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy. Materials and Methods: A nomogram model was developed in a cohort of 127 patients from January 2015 to December 2019. General clinical characteristics including preoperative physical examination data and postoperative pathological features were obtained. The independent risk factors identified by univariate and multivariate COX proportional hazards regression models were used to construct nomogram model. Predictive accuracy and discriminative ability were determined using a concordance index and… More >

FEIFEI TIAN¹, HUAN HU¹, DI WANG¹, HUAN DING¹, QINGJIA CHI², HUAPING LIANG³, WENLI ZENG^4,*

BIOCELL, Vol.46, No.10, pp. 2291-2301, 2022, DOI:10.32604/biocell.2022.020198 - 13 June 2022

Abstract This study used transcriptome and epigenetic data to predict the prognosis of immune-related genes (IRGs) Apelin (APLN) in patients with hepatocellular carcinoma (HCC). The TCGA database has gene expression and clinical data for HCC. And DNA methylation 450 k data for HCC was download from the University of California Santa Cruz (UCSC) Xena browser. Performing clinical and prognostic analysis of APLN expression, results show that APLN is highly expressed in tumor samples. And it has an increasing trend with the development of clinical stage and T stage. To explore the prognostic role of APLN, the… More >