Muhammad Shahid Bhatti^1,*, Saman Azhar¹, Abid Sohail¹, Mohammad Hijji², Hamna Ayemen¹, Areesha Ramzan¹

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 389-406, 2022, DOI:10.32604/cmc.2022.021384

Abstract In the age of the internet, social media are connecting us all at the tip of our fingers. People are linkedthrough different social media. The social network, Twitter, allows people to tweet their thoughts on any particular event or a specific political body which provides us with a diverse range of political insights. This paper serves the purpose of text processing of a multilingual dataset including Urdu, English, and Roman Urdu. Explore machine learning solutions for sentiment analysis and train models, collect the data on government from Twitter, apply sentiment analysis, and provide a python library that classifies text sentiment.… More >

Fatemeh Rahbar¹, Avid Farhang Fagheh², Ayda Khosravi², Siavash Shariatzadeh^2,3,*, Reza Akhavan-Sigari⁴

Molecular & Cellular Biomechanics, Vol.18, No.4, pp. 187-199, 2021, DOI:10.32604/mcb.2021.017750

Abstract The protein ERp57 is a stress-responsive protein, mainly exists in the endoplasmic reticulum (ER), and a small amount in the cell membrane, cytoplasm, nucleus and mitochondria, which is involved in the signal transduction from the cell surface, the regulation process that occurs in the nucleus, and the formation of polymer protein complexes involved in DNA repair. Various degrees of ERp57 dysregulation has been observed in many types of non-communicable diseases especially in cancers. Previous studies showed that the expression of ERp57 could play a key role in occurrence and development of cancers such as breast cancer, gastric cancer, ovarian cancer,… More >

MENG FANG¹, JING GUO¹, HAIPING WANG¹, ZICHANG YANG², HAN ZHAO^1,*, QINGJIA CHI²

BIOCELL, Vol.46, No.2, pp. 401-415, 2022, DOI:10.32604/biocell.2022.016989

Abstract Hepatocellular carcinoma (HCC) is a common immunogenic malignant tumor. Although the new strategies of immunotherapy and targeted therapy have made considerable progress in the treatment of HCC, the 5-year survival rate of patients is still very low. The identification of new prognostic signatures and the exploration of the immune microenvironment are crucial to the optimization and improvement of molecular therapy strategies. We studied the potential clinical benefits of the inflammation regulator miR-93-3p and mined its target genes. Weighted gene co-expression network analysis (WGCNA), univariate and multivariate COX regression and the LASSO COX algorithm are employed to identify prognostic-related genes and… More >

MENGQIU CHENG^1,2, WEI CAO², GUODONG CAO¹, XIN XU^1,2,*, BO CHEN^1,*

BIOCELL, Vol.46, No.1, pp. 97-109, 2022, DOI:10.32604/biocell.2021.015608

Abstract Gastric cancer (GC) is one of the most common cancer worldwide. Although emerging evidence indicates that autophagy-related long non-coding RNA (lncRNA) plays an important role in the progression of GC, the prognosis of GC based on autophagy is still deficient. The Cancer Genome of Atlas stomach adenocarcinoma (TCGA-STAD) dataset was downloaded and separated into a training set and a testing set randomly. Then, 24 autophagy-related lncRNAs were found strongly associated with the survival of the TCGA-STAD dataset. 11 lncRNAs were selected to build the risk score model through the least absolute shrinkage and selection operator (LASSO) regression. Every patient got… More >

VERA KOLYOVSKA^1,#, SONYA IVANOVA², DESISLAVA DRENSKA³, DIMITAR MASLAROV^3,4,#, RENETA TOSHKOVA^1,*

BIOCELL, Vol.45, No.6, pp. 1485-1494, 2021, DOI:10.32604/biocell.2021.016250

Abstract Glycosphingolipids (gangliosides) have been characterized as important biological molecules with a key role as regulators in many physiological processes on cellular, tissue, organ, and organism levels. The deviations in their normal amounts, production, and metabolism are very often related to the development of many multi-factor socially important diseases. GM3 ganglioside, as a small molecule, plays important roles in the cascade regulatory pathways in the pathology of many disorders like neurodegenerative diseases, autoimmune diseases, inflammation, diabetes, malignant transformation, and others. Ganglioside GM3 and its derivatives are membrane-bound glycosphingolipids composed of an oligosaccharide head structure containing one sialic acid residue. These molecules… More >

CHUAN TIAN¹, MUBALAKE ABUDOUREYIMU¹, XINRONG LIN¹, HAO ZHOU², XIAOYUAN CHU¹, RUI WANG^1,*

BIOCELL, Vol.45, No.6, pp. 1527-1541, 2021, DOI:10.32604/biocell.2021.016203

Abstract PSMD14 played a vital role in initiation and progression of hepatocellular carcinoma (HCC). However, PSMD14 and its-related genes for the immune prognostic implications of HCC patients have rarely been analyzed. Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database-Liver Hepatocellular Carcinoma (LIHC). Additionally, we used multi-dimensional bioinformatics analysis to construct and validate a PSMD14-based immune prognostic signature (including RBM45, PSMD1, OLA1, CCT6A, LCAT and IVD) for HCC prognosis prediction. Patients in the high-risk group shown significantly poorer survival than patients in the low-risk group. Calibration curves confirmed… More >

Fei Han¹, Jianghong Qu², Fengyue Li¹, Dapeng Zhang³, Jiangming Qu⁴, Guanghua Li^5,*

Oncologie, Vol.23, No.1, pp. 131-140, 2021, DOI:10.32604/Oncologie.2021.014153

Abstract Aim: This study aims to explore the role of serum long non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) as a diagnostic marker for gastric cancer (GC). Methods: We recruited 76 patients with GC admitted to our hospital (the observation group, OG) and 83 healthy volunteers undergoing physical examinations during the same period (the control group, CG). CCAT2 expression was tested and its correlation with clinicopathological characteristics of GC was analyzed. We also explored the value of CCAT2 in assessing the treatment efficacy, predicting the fatality, and evaluating the prognosis of patients. Results: We detected higher CCAT2 levels in OG… More >

Roderick W. J. van Grootel, Allard T. van den Hoven, Dan Bowen, Tijmen Ris, Jolien W. Roos-Hesselink, Annemien E. van den Bosch^*

Congenital Heart Disease, Vol.16, No.3, pp. 221-232, 2021, DOI:10.32604/CHD.2021.013793

Abstract Aims: To assess the prognostic value of left ventricular (LV) global longitudinal strain (GLS) and global longitudinal early diastolic strain rate (GLSre) with regard to cardiovascular events, as congenital aortic stenosis (AoS) is associated with significant mortality and morbidity but predictors for clinical outcome are scarce. Strain analysis provides a robust and reproducible method for early detection of LV dysfunction, which might be of prognostic value. Methods: This prospective study, included clinically stable patients with congenital AoS between 2011–2013. LV GLS and GLSre was performed in the apical 4, 3 and 2-chamber views using Tomtec software. The endpoint was a… More >

Burcu BİTERGE SÜT^1,*, Ayşe İKİNCİ KELE޲

Oncologie, Vol.22, No.3, pp. 147-154, 2020, DOI:10.32604/oncologie.2020.014449

Abstract Components of the protein synthesis machinery are subjected to alterations in cancer cells. eEF1D gene, which lies within the frequently amplified 8q24 locus, is one of the subunits of the human eukaryotic elongation factor complex. This study aimed to evaluate the prognostic and predictive significance of eEF1D in breast cancer using in silico analysis tools. For this purpose, we analyzed genomic alterations of the eEF1D gene using TCGA datasets via cBioPortal. Histopathological analysis was performed on patient tissue images obtained from cBioPortal and the Human Protein Atlas. Survival analysis was carried out using the KM Plotter and the prediction of… More >

Chuanwei Xu¹, Renju Ding², Chuanping Xu^3,*

Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445

Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than… More >