Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 179-180, 2006, DOI:10.32604/mcb.2006.003.179

Abstract This article has no abstract. More >

C. N. Rios¹, J. N. Augustine¹, A. B. Mathur¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 173-174, 2006, DOI:10.32604/mcb.2006.003.173

Abstract This article has no abstract. More >

Lilan Gao^1,2,*, Qingxian Yuan^1,2, Ruixin Li^3,*, Lei Chen^1,2, Chunqiu Zhang^1,2, Xizheng Zhang^1,2

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 85-98, 2018, DOI: 10.3970/mcb.2018.00329

Abstract Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing stage and the second stable… More >

Pranav S. Sapkal^1,*, Abhaykumar M. Kuthe¹, Shantanu Mathankar², Akash A. Deshmukh

Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 125-136, 2017, DOI:10.3970/mcb.2017.014.123

Abstract β-TCP-Zirconia scaffolds with different architectures were fabricated by means of 3D-Bioplotting in order to enhance the mechanical and in-vitro ability of the scaffold to heal large size bone defects. In the present study scaffold architecture with different strand orientations (0°-90°, 0°-45°-135°-180°, 0°-108°-216° and 0°-72°-144°-36°-108°) were fabricated, characterized and evaluated for mechanical strength and cell proliferation ability. β-TCP powder (25 µm) and PVA (Polyvinyl Alcohol) was acquired from Fisher Scientific, India. Zirconia (18 to 32 µm) was procured from Lobachemie, India. In brief 7.5%, PVA in distilled water was used as a binder and was mixed with 10 grams of (70/30)… More >

Idalba A. Hidalgo A.^∗, Felipe Sojo^†, Francisco Arvelo^†, Marcos A. Sabino^∗,‡

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 85-105, 2013, DOI:10.3970/mcb.2013.010.085

Abstract The electrospinning technique is a method used to produce nano and microfibers using the influence of electrostatic forces. Porous three dimensional networks of continuous and interconnected fibers as scaffolds were obtained from a poly (lactic acid) solution. The concentration of the polymeric solution, 12.5% m/w, as well as the conditions of voltage (V=11kV) and tip-metallic collector distance (H=13cm) were established to develop these scaffolds through the electrospinning process. The characteristics of the scaffolds, such as fiber diameter, sintering and the biomimetics of the characteristics of a native extra cellular matrix were verified by Scanning Electron Microscopy (SEM). The orientation induced… More >

K.W. Luczynski¹, A. Dejaco¹, O. Lahayne¹, J. Jaroszewicz², W.Swieszkowski², C. Hellmich¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 505-529, 2012, DOI:10.3970/cmes.2012.087.505

Abstract A 71 volume-% macroporous tissue engineering scaffold made of poly-l-lactide (PLLA) with 10 mass-% of pseudo-spherical tri-calcium phosphate (TCP) inclusions (exhibiting diameters in the range of several nanometers) was microCT-scanned. The corresponding stack of images was converted into regular Finite Element (FE) models consisting of around 100,000 to 1,000,000 finite elements. Therefore, the attenuation-related, voxel-specific grey values were converted into TCP-contents, and the latter, together with nanoindentation tests,entered a homogenization scheme of the Mori-Tanaka type, as to deliver voxel-specific (and hence, finite element-specific) elastic properties. These FE models were uniaxially loaded, giving access to the macroscopic Young's modulus of the… More >

Milica Radisic^1,2, Gordana Vunjak-Novakovic³

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.1, pp. 1-16, 2006, DOI:10.3970/fdmp.2006.002.001

Abstract To engineer cardiac tissue in vitro with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found in vivo. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply. More >