ANGELES C. TECALCO-CRUZ^*

BIOCELL, Vol.46, No.5, pp. 1209-1213, 2022, DOI:10.32604/biocell.2022.018136 - 06 January 2022

Abstract Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. Cytoskeletal dynamics are modulated by matrix proteins, integrins, and several cytokines in the tumor microenvironment. In this scenario, signaling is activated by integrins and interferons, which can induce ISG15 gene expression. This gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system. Furthermore, non-conjugated ISG15 acts as a cytokine-like protein. In this viewpoint, the interplay between free ISG15, protein ISGylation, and cytoskeletal dynamics in the tumor microenvironment is discussed. More >

CLAIRE ELIZABETH HILLS, ELEFTHERIOS SIAMANTOURAS, PAUL EDWARD SQUIRES^*

BIOCELL, Vol.46, No.4, pp. 937-940, 2022, DOI:10.32604/biocell.2022.018414 - 15 December 2021

Abstract Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and progression. However, these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix, as well as the biophysical and mechanical properties orchestrated by cytoskeletal, membrane and matrix components. To fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function, it is important to consider both biochemical and biophysical attributes of the system being investigated. In this short viewpoint we reflect on our experiences More >

M. CAROLINA DI SANTO^1,2,#, AGUSTINA ALAIMO^1,2,#, ANA PAULA DOMÍNGUEZ RUBIO^1,2, OSCAR E. PÉREZ^1,2,*

BIOCELL, Vol.46, No.4, pp. 885-891, 2022, DOI:10.32604/biocell.2022.018391 - 15 December 2021

Abstract Chitosan-based nanocarriers (CS-NCs) show a promising role in improving drugs and bioactive compounds delivery for therapy. However, the effects exerted by CS-NCs at the cellular level, including their recognition and uptake, have not been fully investigated yet. Many factors, including size, shape, concentration, and surface chemistry of CS-NCs, play an important role in determining the types of intracellular signals triggered. The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells. In the present work, we discuss the… More >

CINZIA SIGNORINI^*, GIULIA COLLODEL, ELENA MORETTI

BIOCELL, Vol.46, No.4, pp. 881-884, 2022, DOI:10.32604/biocell.2022.018062 - 15 December 2021

Abstract The manuscript deals with our studies and experiences in the assessment of cytoskeleton in different cellular models and situations. The immunofluorescent study of several cytoskeletal proteins was relevant in the evaluation of a therapy for osteoarthritis, in case of alkaptonuria and in testing the efficacy of docetaxel in neuroblastoma cancer cells leading to apoptosis. A relevant part of our experience focus on the study of cytoskeleton in seminiferous epithelium and spermatozoa, identifying alterations affecting blood-testis barrier after a silver nanoparticle treatment, chromosomal segregation in case of varicocele, sperm motility and diagnosing systematic sperm defects as More >

R. Joshua Samuel Raj^1,*, J. Prince Antony Joel², Salem Alelyani³, Mohammed Saleh Alsaqer³, C. Anand Deva Durai⁴

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 1171-1188, 2022, DOI:10.32604/cmc.2022.021667 - 03 November 2021

Abstract Human Adaptive Mechatronics (HAM) includes human and computer system in a closed loop. Elderly person with disabilities, normally carry out their daily routines with some assistance to move their limbs. With the short fall of human care takers, mechatronics devices are used with the likes of exoskeleton and exosuits to assist them. The rehabilitation and occupational therapy equipments utilize the electromyography (EMG) signals to measure the muscle activity potential. This paper focuses on optimizing the HAM model in prediction of intended motion of upper limb with high accuracy and to increase the response time of… More >

RAFAEL MORENO-GÓMEZ-TOLEDANO^1,*, MARíA I. ARENAS², ESPERANZA VÉLEZ-VÉLEZ³, RICARDO J. BOSCH¹

BIOCELL, Vol.46, No.2, pp. 305-308, 2022, DOI:10.32604/biocell.2022.017894 - 20 October 2021

Abstract Bisphenol A (BPA) is a xenoestrogen known for its implications for the endocrine systems and several other organs, including the kidneys. Recent renal studies have shown that BPA can induce alterations of the cytoskeleton and cell adhesion mechanisms such as a podocytopathy with proteinuria and hypertension, alterations involved in the progression of renal diseases. These data and the fact that BPA is known to be present in the urine of almost the entire population strongly suggest the critical need to reevaluate BPA exposures considered safe. More >

Muhatasim Intisar¹, Mohammad Monirujjaman Khan^1,*, Mehedi Masud², Mohammad Shorfuzzaman²

Intelligent Automation & Soft Computing, Vol.31, No.1, pp. 101-115, 2022, DOI:10.32604/iasc.2022.019083 - 03 September 2021

Abstract Paralysis is detrimental to people in catastrophic ways: losing income opportunities, becoming a burden to their friends and family, further physical deterioration, and the combination of these occurrences can often lead to depression. In third world countries, suffering from paralysis can be extra deleterious, where a large proportion of the population is engaged in some form of physical labor. The number of people exposed to paralysis risk factors is also increasing, with more and more people having hypertension, smoking, and other abnormalities. Besides, low workplace safety precautions may lead to an increased risk of spinal… More >

Hengyang Wang, Jin Liu^*, Haoliang Ren

Journal on Big Data, Vol.3, No.3, pp. 119-126, 2021, DOI:10.32604/jbd.2021.017184 - 22 November 2021

Abstract The past decade has seen the rapid development of text detection based on deep learning. However, current methods of Chinese character detection and recognition have proven to be poor. The accuracy of segmenting text boxes in natural scenes is not impressive. The reasons for this strait can be summarized into two points: the complexity of natural scenes and numerous types of Chinese characters. In response to these problems, we proposed a lightweight neural network architecture named CTSF. It consists of two modules, one is a text detection network that combines CTPN and the image feature More >

Hichem Guedri^1,*, Abdullah Bajahzar², Hafedh Belmabrouk³

CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.1, pp. 59-77, 2021, DOI:10.32604/cmes.2021.013632 - 30 March 2021

Abstract In recent years, the three dimensional reconstruction of vascular structures in the field of medical research has been extensively developed. Several studies describe the various numerical methods to numerical modeling of vascular structures in near-reality. However, the current approaches remain too expensive in terms of storage capacity. Therefore, it is necessary to find the right balance between the relevance of information and storage space. This article adopts two sets of human retinal blood vessel data in 3D to proceed with data reduction in the first part and then via 3D fractal reconstruction, recreate them in More >

KHAWAR ALI SHAHZAD^1,2,#, ZHONGJIE QIN^3,4,#, YAN LI^1,2,*, DELIN XIA^3,4,*

BIOCELL, Vol.44, No.2, pp. 137-145, 2020, DOI:10.32604/biocell.2020.08500 - 27 May 2020

Abstract Focal adhesions are polyproteins linked to extracellular matrix and cytoskeleton, which play an important role in the process of transforming force signals into intracellular chemical signals and subsequently triggering related physiological or pathological reactions. The cytoskeleton is a network of protein fibers in the cytoplasm, which is composed of microfilaments, microtubules, intermediate filaments, and cross-linked proteins. It is a very important structure for cells to maintain their basic morphology. This review summarizes the process of fluid shear stress transduction mediated by focal adhesion and the key role of the cytoskeleton in this process, which focuses More >