Syed A Jamal^*

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 267-273, 2013, DOI:10.3970/mcb.2013.010.267

Abstract Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) were subjected to in vitro osteogenic differentiation using a novel combination of signaling molecules including BMP-2 and purmorphamine. Differentiation outcomes were assessed by calcein staining and by microscopic examination of the cytoskeleton. Calcein staining showed appreciable degree of calcium mineralization in cell culture, and changes in the morphological attributes of differentiating cells were observed vis-a-vis the actin cytoskeleton. Finally, positive calcein staining, altered cytoskeletal profile, and stress fiber formation in treated cells demonstrated, for the first time, a potentially synergistic interplay between BMP-2 and the hedgehog agonist, purmorphamine. More >

G. Lasko^∗, I. Schäfer^∗, Z. Burghard^†, J. Bill^†, S. Schmauder^∗, U. Weber^∗, D. Galler^‡

Molecular & Cellular Biomechanics, Vol.10, No.1, pp. 27-42, 2013, DOI:10.3970/mcb.2013.010.027

Abstract Owing to the apparent simple morphology and peculiar properties, nacre, an iridescent layer, coating of the inner part of mollusk shells, has attracted considerable attention of biologists, material scientists and engineers. The basic structural motif in nacre is the assembly of oriented plate-like aragonite crystals with a ’brick’ (CaCO₃ crystals) and ’mortar’ (macromolecular components like proteins) organization. Many scientific researchers recognize that such structures are associated with the excellent mechanical properties of nacre and biomimetic strategies have been proposed to produce new layered nanocomposites. During the past years, increasing efforts have been devoted towards exploiting nacre’s… More >

Xuejuan Li^1,2, Jie Ouyang^2,3, Wen Zhou²

CMES-Computer Modeling in Engineering & Sciences, Vol.96, No.6, pp. 379-407, 2013, DOI:10.3970/cmes.2013.096.379

Abstract The three-dimensional (3D) mathematical models for thermal residual stress and warpage are proposed in injection molding, in which the temperature model is rebuilt by considering the phase-change effect to improve the computational accuracy. The 3D thermal residual stress model is transformed into the incremental displacement model so that the boundary conditions can be imposed easily. A modified finite element neural network (FENN) method is used for solving 3D warpage model based on the advantages of finite element method and neural network. The influence of phase-change on temperature is discussed. The numerical simulations of thermal residual More >

Y.C. Shiah¹, C.L. Tan², Y.H. Chen³

CMES-Computer Modeling in Engineering & Sciences, Vol.96, No.4, pp. 243-257, 2013, DOI:10.3970/cmes.2013.096.243

Abstract The present authors have recently proposed an efficient, alternative approach to numerically evaluate the fundamental solution and its derivatives for 3D general anisotropic elasticity. It is based on a double Fourier series representation of the exact, explicit form of the Green’s function derived by Ting and Lee (1997). This paper reports on the successful implementation of the fundamental solution and its derivatives based on this Fourier series scheme in the boundary element method (BEM) for 3D general anisotropic elastostatics. Some numerical examples of stress concentration problems and a crack problem are presented to demonstrate the More >

F.C. de Araújo^1,2, C. R. da Silva Jr.¹, M. J. Hillesheim¹

CMES-Computer Modeling in Engineering & Sciences, Vol.96, No.3, pp. 185-198, 2013, DOI:10.3970/cmes.2013.096.185

Abstract In this paper, the BE SBS (subregion-by-subregion) algorithm, a generic substructuring technique for the BEM, is applied to evaluate stresses at boundary and interfacial points of general 3D composites and solids. At inner points, regular boundary integration schemes may be employed. For boundary or interfacial points, the Hooke’s law along with global-to-local axis-rotation transformations is directly applied. In fact, in thin-walled domain parts, only boundary stresses are needed. As the SBS algorithm allows the consideration of a generic number of subregions, the technique applies to the stress analysis in any composite and solid, including the More >

Changqing Miao¹, Yintao Wei², Xiangqiao Yan¹

CMES-Computer Modeling in Engineering & Sciences, Vol.95, No.6, pp. 519-534, 2013, DOI:10.3970/cmes.2013.095.519

Abstract By using a hybrid displacement discontinuity method, the interactions of three parallel square-hole cracks in an infinite plate subjected to internal pressure are investigated in this paper. Numerical examples are included to illustrate that the numerical approach is very simple and effective for calculating the stress intensity factors (SIFs) of complex plane crack problems. Many numerical results of the SIFs are given and discussed. It is found that a square hole has a shielding effect on crack(s) emanating from the hole. The finding perhaps has an important meaning in engineering. More >

M. G. He¹, C.L. Tan¹

CMES-Computer Modeling in Engineering & Sciences, Vol.95, No.4, pp. 317-349, 2013, DOI:10.3970/cmes.2013.095.315

Abstract The self-regularization technique in the Boundary Element Method (BEM) originally proposed by Cruse and Richardson (1996, 1999) in their work for two-dimensional (2-D) stress analysis is extended to three-dimensional (3-D) elastostatics in this paper. The regularization scheme addresses the issue of accurate numerical evaluation of the integrals due to the singularity of the kernel functions of the integral equations. It is first implemented for the determination of displacements and stresses at interior points of the solution domain, and very accurate results are obtained even when these points are very close to the surface of the More >

Hongtao Wang^1,2, Haitao Wang², Lie Jin², Zhenhan Yao³

CMES-Computer Modeling in Engineering & Sciences, Vol.94, No.6, pp. 529-552, 2013, DOI:10.3970/cmes.2013.094.529

Abstract Since only the boundary of the analyzed domain needs to be discretized, the boundary element method (BEM) inherently has the advantages of solving crack problems. In this paper, a micromechanics BEM scheme is applied to determine the effective elastic moduli of three-dimensional (3-D) solids containing a large number of parallel or randomly oriented microcracks. The 3-D analyses accelerated by the fast multipole method were carried out to investigate the relations between the effective elastic moduli and the microcrack density parameter. Numerical examples show that the results agree well with the available analytical solution and known More >

Changqing Miao¹, Yintao Wei², Xiangqiao Yan¹

CMES-Computer Modeling in Engineering & Sciences, Vol.94, No.1, pp. 29-52, 2013, DOI:10.3970/cmes.2013.094.029

Abstract This paper is concerned with periodic collinear circular-hole cracks in an infinite plate in tension. A numerical approach to this type of circular-hole cracks is presented. Numerical examples are included to illustrate the accuracy of the numerical approach. By means of a generalization of Bueckner's principle and by using a displacement discontinuity method, periodic collinear circular-hole cracks in an infinite plate in tension are investigated in detail by using the numerical approach. Many numerical results are given and discussed. More >

Wen-Ping Wu^1,2, Zong-Zhuan Yao³

CMES-Computer Modeling in Engineering & Sciences, Vol.93, No.4, pp. 235-252, 2013, DOI:10.3970/cmes.2013.093.235

Abstract The internal microstructure evolution and atomic stress distribution around the crack tip of a pre-cracked single crystal nickel with unequal sample sizes are studied by molecular dynamics (MD) simulation. The simulated results indicate that the crack propagation dynamics and stress distributions around the crack tip are strongly dependent on the microstructure evolution caused by the change of sample size. Unequal sample sizes induce various atomic configurations around the crack tip during the crack propagation. When atomic configuration is invariable around the crack tip, the crack grows rapidly along the crack path, the stress concentration occurs… More >